Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0028738 (nystagmus)
 7,431 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Because the current epidemic of drug abuse has touched all levels of society, the primary care physician is increasingly called on to identify, monitor, and treat persons with drug abuse problems. All of the major drugs of abuse, including cocaine, marijuana, amphetamine, phencyclidine, heroin, and alcohol, may produce typical eye signs that can be easily detected by a rapid eye test. These signs include ptosis, abnormal pupil size, nonreactivity of the pupil to a light challenge, nystagmus, and non-convergence. When eye signs are detected, drug use should be confirmed by analysis of body fluids. The rapid eye test is suitable for routine use when screening adolescents, athletes, and employees with jobs where safety is essential.
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PMID:The rapid eye test to detect drug abuse. 338 46

Syphilis is a multisystemic disease that may also affect the inner ear. The objective of this study was to investigate the frequency, clinical presentation and outcome of otosyphilis. A retrospective analysis of inpatients seen by a team of ENT specialists and dermatologists at a teaching hospital in Dresden, Germany, during 1986-2000. Six cases of otosyphilis had been diagnosed. None was related to risk factors such as HIV infection or drug abuse. We identified four female and two male patients, age range 25-58 years. Four patients suffered from syphilis stage II, one from syphilis stage and another from congenitial syphilis. ENT complaints included loss or impairment of hearing, tinnitus and nystagmus. All were treated with penicillin G. Adjuvant therapy included systemic corticosteroids oral pentoxifillin in two patients each. Improvement of ENT symptoms was achieved in all but one patient, who suffered from congenitial syphilis. This study confirms that otosyphilis is still a complication of syphilis in developed countries. The first line therapy is systemic penicillin G. There is a lack of controlled trials for adjuvant treatments such as corticosteroids and pentoxifillin. Clinical cooperation between dermatologists/venereologists and ENT specialists supports the best outcome.
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PMID:Otosyphilis: report on six cases. 1519 56