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Query: UMLS:C0027960 (mole)
 21,279 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mucin deposition has been reported in a variety of cutaneous neoplasms, including melanocytic nevi. We describe a series of melanocytic nevi with nodular myxoid change.
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PMID:Nodular myxoid change in melanocytic nevi. A report of two cases. 887 5

Mucin deposition is seen in the stroma of a variety of cutaneous neoplasms. Although reported, it is uncommon in melanocytic tumors. Observation of abundant mucin in the stroma of some cases of melanocytic nevi prompted us to review all cases of dermal and compound nevi in a 6-month period. We found that dermal nevi had a higher incidence of mucin in the stroma than compound nevi (2.75% vs 0.55%). The mucin was seen both in stroma and within the nests of nevus cells. The cause and significance of mucin deposition are not known.
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PMID:Mucinous changes in melanocytic nevi and review of the literature. 1849 24

Mucin deposition in Spitz nevus seems to be a very rare phenomenon, as there have only been 3 cases previously published. We report 6 additional cases, half of them in women, and half in men. The ages of the patients varied from 5 to 47 years (mean = 30.17). Sizes of the nevi varied from 3 to 6 mm. Four lesions were located on the extremities, whereas one was located on the trunk (there was no clinical information about the other). A vascular lesion was suspected in 2 cases. Excision with clear margins was achieved in all cases but one. So far, there have been no recurrences after follow-ups varying from 1 to 5 years. The biopsy showed a symmetrical melanocytic Spitz nevus in all cases. Three cases were compound, and 3 cases were junctional nevi. The epidermis was either acanthotic or hyperplastic in all cases, with no epidermal consumption. Kamino bodies were found in 4 cases. The deposit of mucin was moderate in 5 cases and mild in one case. Mucin was found in the stroma between the dermal melanocytes in cases of compound nevi and in the melanocytic nests of the junctional component.
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PMID:Myxoid Spitz Nevi: Report of 6 Cases. 2839 1

We report 2 cases of benign intradermal melanocytic nevi with discrete glandular elements and mucin deposition engendering a diagnostic dilemma. The preliminary differential included entrapment of adnexal structures, collision with an adnexal neoplasm such as adenoid cystic carcinoma or metastatic adenocarcinoma. A colloidal iron special stain confirmed the deposition of mucin; however, a pankeratin AE1/AE3 immunohistochemical cocktail was surprisingly negative. Closer cytological examination of the discrete "glands" combined with nearby pseudoangiomatous (almost kaposiform) change hinted at melanocytic origin, which was confirmed with a positive melanoma antigen recognized by T-cells 1 immunohistochemical stain. Histopathological variations in melanocytic morphology include balloon cell formation, pseudoangiomatous change, lipomatous change, nevus of Nanta (osteonevus) with osseous metaplasia, neurotization, cartilaginous nevus, calcification, increased elastic tissue, psamomma body formation, amyloid deposition, eczematous changes (Meyerson nevus), granular cell change and ancient change/atypia. Mucin deposition, tubule and pseudoacini formation, and now discrete adenoid cystic-like "glands" may also be seen, all of which are important to recognize to avoid misdiagnosis.
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PMID:Two cases of discrete adenoid pseudogland formation within benign intradermal melanocytic nevi. 2962 14