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Query: UMLS:C0027960 (mole)
 21,279 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An electron microscope study of tissue diagnosed as white sponge nevus suggested a more advanced process of cellular keratinization in the buccal mucosa than may be appreciated in histologic sections. Ultrastructural features which are normally associated with keratinizing epithelium were observed in the lesion and included (1) a marked increase in the intracellular content of tonofilaments, (2) numerous tonofilament-related keratohyaline granules, (3) membrane-coating granules that possessed an internal striated appearance, (4) the apparent accumulation in the intercellular space of the contents of the striated microgranules, and (5) the presence within some cells of a keratin-like material. Other features included the formation of perinuclear electron-lucent zones and the presence of elongated cytoplasmic processes which produced a complex pattern of interdigitation among the epithelial cells.
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PMID:Ultrastructure of the white sponge nevus. 5 56

An 8-year-old girl with a non-familial case of white sponge nevus (WSN) is presented. The differential diagnosis is discussed with reference to anamnestic, clinical and histopathological data. In keratin expression, WSN resembles the epithelia of the hard palate and the tongue.
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PMID:[Nevus spongiosus et albus mucosae]. 137 90

The clinical, histological and histogenetic aspects of naevus follicularis keratosus (NFK) ("naevus comedonicus") are reported. Clinically, NFK appears mostly as linear and unilateral groups of dark comedo-like plugs. Clinical forms include variants with minimal and distinctive deviations from the basic form. Recurrent inflammation is not mandatory. Histological examination reveals keratin-filled infundibula, with granular layers that are always present but though not always equally obvious. This finding corresponds to the mode of keratinization in the follicular infundibulum. Overall, the findings are indicative of a harmartoma of the follicular infundibulum with additional rudimentary sebaceous glands.
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PMID:[Naevus follicularis keratosus: clinical aspects, histology and histogenesis]. 159 69

Skin lesions of three patients with inflammatory linear verrucose epidermal naevus (ILVEN) were examined. Histologically, orthokeratosis and parakeratosis were alternately seen in the acanthotic epidermis. By N-(7-dimethylamino-4-methyl-3-coumarinyl)maleimide staining, the horny cells in the parakeratotic epidermis showed a cytoplasmic SH pattern and a weak membranous SS pattern. The orthokeratotic epidermis revealed an increased involucrin expression, whereas the parakeratotic epidermis showed almost no involucrin expression. Ultrastructurally, in the parakeratotic epidermis, the living keratinocytes had prominent Golgi apparatuses and vesicles in the cytoplasm. In the intercellular spaces in the upper spinous layer through to the lower horny layer, an electron dense, homogeneous substance was deposited. The cytoplasm of the horny cells was filled with keratin filaments and contained remnants of nucleus and cytoplasmic membrane structures, and some lipid droplets. The marginal band formation was incomplete. Most of these ultrastructural abnormalities were not found in the orthokeratotic epidermis. There are both similarities and differences in histopathogenesis of the parakeratotic epidermis between ILVEN and psoriasis. A unique finding was the lack of involucrin expression in the ILVEN parakeratotic epidermis.
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PMID:Histopathogenesis of inflammatory linear verrucose epidermal naevus: histochemistry, immunohistochemistry and ultrastructure. 172 70

Naevus comedonicus is a rare disorder of the skin which is due to defect development of the hair follicles. The undifferentiated epithelium of the hair follicles produces keratin, which is packed in laminated layers and forms a plug. The keratin plug expands the follicle and gives the clinical appearance of a naevus comedonicus with dark and vaulted crypts of the skin. Comedones appear mainly on the face, neck and trunk. The condition is usually asymptomatic, but may be complicated by infection and scarring. No malignancy has been reported. Local treatment may be application of retinoic acid. This accelerates the exfoliation of the epithelium, and the expulsion of the keratin layers prevents the formation of keratin plugs in the skin. The treatment with retinoic acid will not eliminate the crypts and pits in the skin. Surgical treatment seems to be the best alternative.
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PMID:[Nevus comedonicus. A rare skin disease of the hair follicles]. 206 60

One hundred cutaneous tumors were investigated immunohistopathologically for the expression of intermediate filament (IF) proteins. Epithelial tumors, such as basocellular and squamous cell carcinomas, cutaneous adnexal tumors, and metastatic carcinomas showed keratin positivity in a varying number of tumor cells with two keratin antibodies with different specificities. Neoplastic cells of fibrohistiocytic tumors, pigmented nevi, melanomas, hemangiomas, glomus tumors, and lymphomas were positive for vimentin, but not for keratin or desmin. Cutaneous leiomyomas and leiomyosarcomas, on the other hand, were positive for desmin. The results show that the typing of IFs enables the differential diagnosis between carcinomas and sarcomas or melanomas, epidermal appendage tumors, and mesenchymal tumors, and between fibrohistiocytic and leiomyocytic tumors, and therefore are of diagnostic value in histopathologic problems of the skin.
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PMID:Antibodies to intermediate filament proteins. The differential diagnosis of cutaneous tumors. 240 82

Dermal nevocytic nevi (NN) were histochemically studied with the help of FITC-conjugated lectins as well as antisera against keratin and plasminogen activators of the urokinase type. 3 out of 18 NN showed interpenetrating nevus cells in atrophic parts of the epidermis. These cells revealed strong lectin reactivity both with Con A (cytoplasmatic binding) and WGA/RCA II (membraneous binding). In addition we found membraneous reaction with anti-urokinase, whereas there was no anti-keratin staining. Our findings suggest active transepidermal elimination of nevus cells in dermal nevocytic nevi.
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PMID:[Histochemical studies of transepidermal elimination of nevus cells in nevus cell nevi of the corium]. 247 58

The majority of melanocytic tumours are easily diagnosed but they become a problem when they are amelanotic and the tumour cells resemble those of other tumours. This applies particularly to secondary melanoma. Detection of S100 protein is a useful identifying marker. S100 protein, so named for its solubility in saturated ammonium sulphate, is derived from brain tissue. It is a dimer and belongs to a calcium binding group of proteins. The protein was first thought to be in neural or neural crest derived tissues but has been found in chondrocytes, adipocytes, myoepithelial cells, dendritic cells of lymphoid tissue, Langerhans cells and T lymphocytes. The protein is present in a high proportion of malignant melanomas and nevocytic nevi of skin, but is less positive in eye melanomas. It is present in gliomas, Schwannomas and neurofibromas but not in neurone derived tumours such as neuroblastomas. Chondromas, chondrosarcomas, liposarcomas, some osteogenic sarcomas and some histiocytic tumours are positive. The tumours that do not contain S100 protein are listed. Pending development of melanoma-directed monoclonal antibodies, the use of anti-serum to S100 protein plus anti-keratin and anti-leukocyte reagents is useful in the identification of tumours of doubtful histogenesis.
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PMID:S-100 protein as a marker for melanocytic and other tumours. 299 6

We have studied the expression of involucrin in a variety of keratinization disorders, mostly of genetic origin using an avidin-biotin-peroxidase technique. In normal human epidermis 25% of the living epidermis was labelled. The diseases studied fell into two groups. Diseases with greatly increased involucrin staining including collodion baby (38%), Darier's disease (49%), Flegel's disease (56%), erythrokeratoderma variabilis (60%), epidermal naevus with epidermolytic hyperkeratosis (45%) and congenital bullous (58%) and non-bullous (44%) ichythyosiform erythroderma; and diseases with normal or slightly increased staining, including ichthyosis vulgaris (27%), X-linked ichthyosis (25%), confluent and reticulate papillomatosis (27%) and simple epidermal naevus (28%). These results demonstrate that involucrin expression is altered in some keratinization disorders and suggest that in such conditions cellular functions other than keratin metabolism are also affected.
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PMID:Involucrin expression in keratinization disorders of the skin--a preliminary study. 367 94

Nevus cell aggregates occurring in association with axillary lymph nodes can be difficult to recognize and differentiate from a metastatic breast carcinoma. We believe S100-protein immunoreactivity, along with negative staining for keratin and epithelial membrane antigen, and typical geographic distribution of nevus cell aggregates in lymph nodes are helpful in providing an accurate diagnosis.
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PMID:Nevus cell aggregates associated with lymph nodes. Immunohistochemical observations. 384 Mar 58


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