Gene/Protein Disease Symptom Drug Enzyme Compound
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 21,279 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Nonhuman primates used in these studies had been fed for 5 years diets enriched with cholesterol and one of three classes of fatty acids: saturated, monounsaturated, or polyunsaturated fatty acids. Atherosclerotic iliac artery lipid extracts were quantitatively analyzed for cholesterol, cholesteryl esters, fatty acid composition, and a marker of lipid oxidation, the F(2)-isoprostanes. There was no significant difference in the mean accumulation of F(2)-isoprostanes among the different diet groups. To account for the small, individual variation in the arachidonate concentration the F(2)-isoprostane mass from each sample was normalized by dividing by arachidonate mass: F(2)-isoprostane mass/(mass arachidonate). At lower levels of cholesterol accumulation, the F(2)-isoprostane mass/(mass arachidonate) ratio was greater in lipids from POLY arteries compared to SAT arteries, but the reverse was true at high levels of cholesterol. F(2)-isoprostane/(mass arachidonate) increased with mole fraction linoleate for the SAT group, but decreased for the POLY group. In summary, these studies demonstrated that there is no simple explanation of how F(2)-isoprostane accumulation did not depend on the concentration of oxidizable lipids that promote free-radical lipid oxidation.
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PMID:Isoprostane levels in lipids extracted from atherosclerotic arteries of nonhuman primates. 1139 Jan 78

The sitting-atop complexation of meso-tetraarylporphyrins and its para-substituted derivatives (H(2)t(4-X)pp, X:H, Br, Cl, CH(CH(3))(2), OCH(3), CH(3)), as electron donors, with zirconyl, as an electron acceptor, have been investigated spectrophotometrically in chloroform. The mole ratio studies based on physicochemical techniques were employed clearly and revealed the formation of 1:1 sitting-atop complexes which was confirmed by UV-vis, (1)H NMR and IR spectroscopic data. The value of the formation constant was estimated for each complex using a nonlinear optimization of the complex absorbance vs. mole ratio data by package KINFIT. The results showed that the stability of these complexes decreases with the temperature enhancement. Thermodynamic parameters, DeltaG degrees , DeltaH degrees and DeltaS degrees , of the SAT complexes have been determined from the temperature dependence of formation constants by Van't Hoff equation. Also, the influence of the substituents of the aryl rings in H(2)t(4-X)pp on the stability of the SAT complexes is discussed.
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PMID:A spectrophotometric and thermodynamic study of the sitting-atop complex formation from reaction between free base meso-tetraarylporphyrins and zirconyl nitrate in chloroform solution. 1961 33

The present study describes the synthesis of different mole densities of poly(propylene glycol)dimethacrylate cross-linked resins using monomer units such as styrene and 4-chloromethyl styrene and its evaluation as an ideal support toward different stages of solid-phase peptide synthesis. Free radical generated aqueous suspension polymerization has been followed for polymerization and the formation of resin was characterized using infrared and carbon-13 spectroscopic techniques. Surface morphology of resin was examined by scanning electron microscopy. The polymerization reaction was investigated with respect to the effect of amount of cross-linking agent to verify the swelling, loading, and the mechanical stability of resin. Solvent imbibition abilities in commonly used solvents were measured and compared to commercially available Merrifield as well as reported styrene-acryloyloxyhydroxypropyl methacrylate-tripropyleneglycol diacrylate (SAT resins. The chemical inertness of the support was also checked with different reagents used for solid-phase peptide synthesis. The suitability of support was demonstrated by synthesizing biologically potent Endothelin class of linear peptides by Fmoc strategy and compared to SAT resin. The purities of synthetic peptides were analyzed by high-performance liquid chromatography and corresponding masses by matrix-assisted laser desorption/ionisation-time of flight analysis.
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PMID:Synthesis, characterization, and evaluation of PS-PPDC resin: a novel flexible cross-linked polymeric support for solid-phase organic synthesis. 2278 66