Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027960 (mole)
 21,279 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of serum human chorionic gonadotropin (hCG) level on gonadotropin response to a single intravenous injection of luteinizing hormone-releasing hormone (LH-RH) or conjugated estrogen (Premarin) was investigated in patients after abortion of a hydatidiform mole. 17 women (aged 23-29 years) with an aborted mole without theca lutein cyst were examined until 5 months after molar abortion. Response to gonadotropin was little at a hCG level of 100 mIU/ml or more, but the response of LH and follicle stimulating hormone (FSH) to LH-RH was restored to normal when the serum hCG level decreased to below 100 mIU/ml. A normal response of LH to conjugated estrogens was observed at a serum hCG level of 20 mIU/ml or less. Apparently, a high level of hCG interferes with pituitary gonadotropin secretion. The threshold hCG levels for normal responses of gonadotropins to LH-RH and estrogens are 100 and 20 mIU/ml, respectively. The secretion of gonadotropins was restored even in the presence of low hCG with either LH-RH or conjugated estrogen induction.
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PMID:Restoration of the gonadotrophin response to LH-RH and oestrogen administration in patients after molar abortion. 22