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Query: UMLS:C0027960 (mole)
 21,279 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Further finestructural characteristics of melanosomes in pigmented nevi and melanomas are described. The differences in the calcium, iron and surphur content of melanosomes derived from melanocytes, nevocytes and malignant melanoma cells are pointed out.
Arch Dermatol Forsch 1975 Jul 18
PMID:Fine structure and x-ray microanalysis of melanosomes in pigmented nevi and melanomas. 116 39

Junction nevus, dermal nevus, melanosis circumscripta praecancerosa Dubreuilh, superficial spreading melanoma, and nodular melanoma were investigated and characterized by use of the formalin induced fluorescence method (FIF). In the vicinity of junctional nevus cell clusters and near tumor cells of the superficial spreading melanoma increased numbers of melanocytes are found. These show different types of dendritic branching. Spherical nevus cells however are completely devoid of dendritic processes. On the other hand, the atypical pigment cells in melanosis circumscripta praecancerosa Dubreuilh exhibit a shape similar to that of melanocytes, whereas the globular cells of superficial spreading melanoma have the appearance of nevus cells. The arrangement of nodular melanoma cells resembles that observed in dermal nevus. However the characteristic decrease in fluorescence intensity from epidermal junction to deeper dermis as observed in the dermal nevus was missed in nodular melanomas. Dendritic pigment cells displaying formalin induced fluorescence (FIF) could be demonstrated in all types of malignant melanomas investigated in the present study. The fluorophores of the pigment lesions are characterized microspectrofluorimetrically by (1) ill-defined emission maxima between 470 and 490 nm and (2) a clear-cut excitation maximum at 430 nm accompanied by a lower one at 320 nm. Hydrochloric acid vapor induces a hyposochromic shift of the 430 nm excitation maximum to 370-380 nm and a marked elevation of the 320 nm maximum. These results indicate fluorophores of DOPA and its derivatives; in this respect there are no marked differences between melanocytes, nevus cells and the cells of malignant melanoma.
Arch Dermatol Res 1975 Sep 12
PMID:[Fluorescence histochemical and microfluorometrical investigations of pigmentary tumors of the skin (author's transl)]. 119 Aug 35

Histological markers enable the correct diagnosis of a pigmented lesion that histologically resembles a superficial spreading malignant melanoma and yet behaves in a wholly benign way. This pseudomelanoma occurs in young adults within a few weeks following partial surgical-shave excision of an intradermal melanocytic nevus.
Arch Dermatol 1975 Dec
PMID:Pseudomelanoma: recurrent melanocytic nevus following partial surgical removal. 120 Jun 64

By labelling dermal infiltrate cells with H3-thymidine, two types of skin tumours can be distinguished: one type with many labelled cells in the infiltrate (H3-thymidine labelling index, H3-I), the other with few labelled cells. Type I includes malignant melanoma (H3-I = 2.2%) and hemangioendothelioma (2.8%). Type II includes metastases of malignant melanoma (1%), squamous cell carcinoma (1.1%), basel cell epithelioma (0.5%), nevus cell nevus (0.6%), and nevoid lentigo (0.4). The number of labelled cells in the cellular reaction of Type II tumours does not differ significantly from that in normal human corium (0.75%), though there may be a dense cellular reaction. DNA-synthesizing cells were classified with the aid of characteristical stainings and histochemical methods. A vast majority of them were found to be lymphocytes. Our research underlines the special importance of cellular inflammatory reaction, i.e. cellular immunity, im malignant melanoma and probably in hemangioendothelioma.
Arch Dermatol Res 1975 Oct 29
PMID:Lymphocyte stimulation in the cellular inflammatory reaction of some human skin tumours. 120 Jul 1

Naevus superficialis lipomatosus (NSL) is a rare malformation consisting of multiple or solitary papules usually occurring on the lower trunk or gluteal regions. In this study the clinical features of twenty new cases are described with a detailed account of the histopathology. Notable were the marked variability in the amount of ectopic fat found in the lesions, and the presence of associated abnormalities of the connective tissue, the vessels, and the skin appendages. In early lesions, mononuclear cells differentiating into lipoblasts could be identified around proliferating capillaries. Two clinical types were distinguished. First, the classical type (7 cases) consisting of multiple lesions occurring in a zonal distribution, and secondly the solitary papule or nodule (13 cases). The latter type can be difficult to distinguish from a skin tag with fatty herniation.
Br J Dermatol 1975 Aug
PMID:Naevus superficialis lipomatosus. A clinicopathological report of twenty cases. 123 80

A patient had two fleshy, nontender masses, each partially filling an axillary vault. These tumors arose at puberty in normal-appearing axillae. The masses were accompanied by localized hyperhidrosis. Histopathological examination of the lesions showed that the reticular layer of the dermis had been replaced solely by lobular masses of unencapsulated, mature apocrine elements. These very rare tumors are best classified as apocrine gland organic hamartomas, or apocrine nevi. To our knowledge, such a case has never been reported or photographed.
Arch Dermatol 1976 Apr
PMID:Apocrine gland organic hamartoma (apocrine nevus). 126 60

Thirty moles have been studied by in vitro techniques employing tritiated precursor compounds in order to demonstrate replicative and metabolic activity in naevus cells. Autoradiographs prepared from the incubated tissue showed that replicative activity occurred at all anatomical levels within the naevi. Synthesis of macro-molecules also occurred throughout the mole, but more actively in the junctional and superficial zones. The term 'Junctional Activity' does not appear to have any meaning in cell kinetic terms, and is not associated with any proliferative capacity.
Br J Dermatol 1976 May
PMID:Cell division and metabolic activity of naevus cells. The relationships between anatomy and behaviour in moles. 126 66

Straight-hair nevus of the scalp is a distinct clinical entity. A case is reported and 2 other cases from the literature are reviewed. In our patient, specific morphology of the hair shown by scanning electron microscopy suggested a disorder in keratogenesis from loss of cuticular cells. Straight-hair nevus is probably a form of localized trichodysplasia.
Int J Dermatol
PMID:Straight-hair nevus syndrome: a case report with scanning electron microscopic findings of hair morphology. 127 72

Malignant blue nevus is uncommon compared to its benign counterpart and is regarded as a rare form of malignant melanoma. We report the clinical and histological findings in eight cases. Histologically, all eight specimens showed no epidermal involvement and had contained within or were adjacent to portions of blue nevus or cellular blue nevus. Proliferation of bundles of bipolar spindle shaped cells with marked cellular atypia, mitotic figures, foci of necrosis, and inflammatory cell infiltrate were noted. Two of the cases were studied by DNA flow cytometry and the populations of tumor cells were found to be diploid. Two cases have died secondary to metastasis. Although malignant blue nevi may not behave as aggressively as nodular malignant melanoma, they have definite potential to do so and therefore should be removed by wide surgical excision.
J Dermatol Sci 1992 Nov
PMID:Malignant blue nevus: a report of eight cases. 128 70

Benign tumors and "dark lesions" accounted for 22% of vulvar disease seen in the Vulvar Clinic at the Milwaukee County Medical Complex over an 8-year period. Biopsy confirmation was obtained for 269 lesions. The order of frequency of lesions in this study was as follows: epidermal inclusion cyst, lentigo, Bartholin's duct obstruction, carcinoma in situ, melanocytic nevi, acrochordon, mucous cyst, hemangiomas, postinflammatory hyperpigmentation, seborrheic keratoses, varicosities, hidradenomas, verruca, basal cell carcinoma, and, last, unusual tumors such as neurofibromas, ectopic tissue, syringomas, and abscesses. The variability in clinical appearance of vulvar tumors suggests that biopsy confirmation should be obtained on all lesions for which there is the least doubt regarding the diagnosis.
Dermatol Clin 1992 Apr
PMID:Benign vulvar tumors. 131 12


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