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Query: UMLS:C0027960 (mole)
 21,279 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We all would like to reduce the pain of injecting a local anesthetic, to simplify the treatment of xanthelasma palpebrarum and chondrodermatitis nodularis; and to improve methods of shave excision of nevi and cosmetic extirpation of large seborrheic keratoses. Here are some tips that might help.
J Dermatol Surg 1976 Jun
PMID:Little tips with big rewards. 93 1

A case of pigmented naevi arising in an albino is described. The histological appearance of a naevus is described in the nature of the pigment discussed.
Br J Dermatol 1976 Aug
PMID:Multiple pigmented naevi in an albino. 95 58

A child with an epidermal nevus was diagnosed at the age of 15 months as having an embryonal rhabdomyosarcoma of the bladder. This child also had pigmentary abnormalities characteristic of the epidermal nevus syndrome. The question is again asked whether patients with epidermal nevi have an increased incidence of tumors. It is suggested that the thorough evaluation of these patients as recommended by Solomon should also include an alertness for the development of earlier-than-anticipated neoplasms.
Arch Dermatol 1976 Oct
PMID:Epidermal nevus and rhabdomyosarcoma. 96 36

We report three cases of alopecia areata occurring around central, pigmented nevi. The histologic appearance of the central nevus was that of the halo nevus. Removal of the nevus did not appear to alter the natural course of the alopecia. Histochemical studies showed a substantial increase of acid mucopolysaccharides in the dermis in each case.
Arch Dermatol 1976 Oct
PMID:Perinevoid alopecia. An unusual variety of alopecia areata. 96 38

The activities of 27 enzymes of carbohydrate metabolism and the proportions of lactate dehydrogenase isoenzymes were determined in epidermis, in superficial epitheliomas and in several solid tumours biopsied from a patient with basal-cell naevus syndrome. The activity patterns varied from that of normal epidermis to that found in basal-cell epitheliomas. Thickened epidermis, superficial epitheliomas and some of the solid tumours presented an intermediate pattern. Histologically similar lesions sometimes differed markedly in their enzyme activities.
Arch Dermatol Res 1976 Aug 27
PMID:Enzymes of carbohydrate metabolism in naevoid basal-cell epithelioma. 96 85

A man born with a unilateral epidermal naevus on the right side of the abdomen developed at puberty symmetrical benign acanthosis nigricans in the body folds. The symmetrical eruption later disappeared completely. The unilateral epidermal naevus and the symmetrical eruption showed identical histological features, i.e. those of acanthosis nigricans. At the age of 32 he developed a muco-epidermoid cancer of the left parotid gland. A decision whether the association of unilateral epidermal naevi with malignant tumours occurs with unusual frequency requires (a) a long follow-up of the patient with the unilateral naevus, (b) a differentiation of the unilateral eruption from unilateral malignant acanthosis nigricans and (c) statistical evidence.
Br J Dermatol 1976 Oct
PMID:Unilateral epidermal naevus resembling acanthosis nigricans. 97 30

A case of the epidermal naevus syndrome is presented. Huge enlargement of both lower limbs was the presenting symptoms together with an extensive veavus unius lateris on the trunk.
Br J Dermatol 1976 Dec
PMID:Epidermal naevus syndrome. 100 11

Microcytotoxicity assays of patients with malignant melanoma and halo nevi were performed. No good correlation could be found between percent cell inhibition and histopathological level of melanoma or the clinical staging. The percent cell inhibition was usually an index of response to vaccinia virus immunotherapy. Actively regressing halo nevi showed high levels of percent cell inhibition, whereas inactive halo nevi had low levels of percent cell inhibition and blocking factor. Immunologic reactivity to melanoma cells may be a common feature of melanoma and halo nevus.
Arch Dermatol 1975 Jun
PMID:Microcytotoxicity and serum blocking factors in malignant melanoma and halo nevus. 109 59

Subcellular defects of hypomelanosis in tuberous sclerosis (TS) (28 subjects) were compared by light and electron microscopy with oThere forms of congenital circumscribed hypomelanosis that occur in nevus depigmentosus (ND) (8 subjects) and in piebaldism (PB) (4 subjects), respectively. On the light microscopic level in both TS and ND, the population density of functioning melanocytes was normal but each perikaryon was small, and dopa activity was decreased. On the ultrastructural level, the hypomelanotic skin and hair of TS were associated with a decrease in the synthesis, melanization, and size of melanosomes; the decrease in the size of melanosomes resulted in the aggregation of melanosomes (i.e., a melanosome complex) in the keratinocytes in all the specimens examined. In ND, ther were no obvious changes in the size and melanocytes. the hypomelanosis of ND is related to the decreased synthesis and also, perhaps, abnormal transfer of melanosomes. In PB the hypomelanosis of the skin and hair results from the absence of functional melanocytes. The hypermelanotic areas of PB, however, characteristically contain melanocytes that synthesize abnormal (sperical and granular) as well as normal (ellipsoidal and lamellar) melanosomes.
J Invest Dermatol 1975 Jan
PMID:Congenital circumscribed hypomelanosis: a characterization based on electron microscopic study of tuberous sclerosis, nevus depigmentosus, and piebaldism. 111 Mar 5

Electron microscopic investigations revealed numerous unmyelinated nerve fibres in different types of pigmented nevi. The structure of these fibres was similar to the cutaneous unmyelinated fibres. Axon terminals were observed between nevus cells and smooth muscle cells, the former proved to be efferent-type free endings. Pure receptor-type endings were rarely seen. The contradiction between the receptor-like construction ov nevic corpuscles and the abundance of the effector-type endings is discussed.
Arch Dermatol Forsch 1975
PMID:Nerves and nerve endings in pigmented nevi. Part I. 113 Aug 24


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