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Query: UMLS:C0027960 (mole)
 21,279 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case diagnosed to have the lesion of pachydermatocele type of Recklinghausen's disease in a 28-year-old female was studied mainly by means of fluorescence method (Falck and Hillarp). Histopathological examination revealed that the lesion was composed of Ota's nevus-like changes in the epidermis to the middermis and of proliferation of neurofibromatous tissues coexisting with melanin-producing cells in the lower dermis to the subcutaneous adipose tissue. Melanin-producing cells in the neurofibromatous lesion were shown by fluorescence method to have characteristics of nevus cells rather than of melanocytes. Innervation of monoaminergic and cholinergic nerves was not found to the arteries in neurofibromas. These findings are thought to suggest that the abnormalities of not only Schwannian cells and melanocytes of neural crest origin but also of nevus cells and autonomous nerves of neural crest origin are related with the pathogenesis of pachydermatocele type of Recklinghausen's disease.
Arch Dermatol Res 1976 Oct 27
PMID:Melanin-producing cells seen in neurofibromatous lesions of Recklinghausen's disease -- a study with fluorescence method (Falck and Hillarp). 82 49

Thirty-five infants with nevus flammeus were treated with carbon dioxide snow at intervals of two weeks. The treatment was initiated between the first and eleventh week, and improvement was found to be best when started between the age of 3 and 6 weeks. The result was excellent in 8 cases, good in 11, fair in 12, and poor in 4.
J Dermatol Surg Oncol
PMID:Cryotherapy with solid carbon dioxide in the treatment of nevus flammeus. 86 80

Lenticular or linear, buccal or labial, slate-coloured or melanic black spots are noticed in healthy subjects with no racial, hormonal or drug factor. Histological examination shows a pigmentary excess of the basement membrane without anomaly or dystrophy or nevus cells. Ultrastructural study shows a great number of intracyto-plasmic melanosomes, isolated or in group in all the keratinocytes in the third inferior part of the epidermis. No explanation can be given to this melanocyte hyperactivity. An excision can be done without danger for esthetical purpose.
Ann Dermatol Venereol 1977 Mar
PMID:[Essential melanic pigmentation of the mouth and the lips]. 86 59

We saw three patients with inflammatory linear verrucose epidermal nevus (ILVEN). The purpose of this study is to better delineate the histopathologic features of this type of nevus. In fact, in all three cases very particular, specific histologic lesions have been noted that permit us to better distinguish this recently outlined entity. The histologic features were depressed, cup-like areas of hyper-granulosis with overlying orthokeratotic hyperkeratosis, alternating (with sharp dermacation) with raised, level areas of agranulosis with overlying parakeratotic hyperkeratosis.
Arch Dermatol 1977 Jun
PMID:Inflammatory linear verrucose epidermal nevus. A pathologic study. 86 46

A 25-year-old male is described who had extensive linear comedo naevi present from birth, involving the face, both sides of the trunk, both arms, one palm, both legs and one sole. Within these lesions multiple trichilemmal cysts were arising giving rise to a zosteriform pattern of skin nodules. Both lesions were confirmed histologically. It is suggested that comedo naevus is a hamartomatous abnormality of the hair follicle in which all layers, including the external root sheath, are involved and from which trichilemmal cysts may arise.
Br J Dermatol 1977 May
PMID:Trichilemmal cysts arising in an extensive comedo naevus. 87 91

In the vast group of linear dermatoses a very particular topographic type can be distinguished, i.e., the axial dermatoses which very electively follow the linear course of Scherington's axial lines. This feature can be found in several dermatoses and particularly in lichen striatus and acantholytic linear naevus. Topographically, the axial dermatoses are quite similar to the pigmentary demarcation lines which also follow the same course. Despite numerous patholgenic unknown facts, the concept of axial dermatoses certainly contributes to a better knowledge of the still obscure linear dermatoses.
Ann Dermatol Venereol 1977 Apr
PMID:[Axial dermatoses (author's transl)]. 88 34

The morphological substrates of pigmented and depigmented skin as well as the structural characteristics of spontaneously developing melanomas were revealed by clinical, light- and electron microscopic methods in gray horses (Lipizzaner breed) from the Vienna Spanish Riding School. On clinical investigations in a group of 31 older horses (more than 10 years old) 20 exhibited melanomas, whereas 23 younger animals (less than 10 years of age) had no evidence for visuable melanotic tumors. Concomitantly with the progressive graying of the hair a depigmentation of the skin was frequently observed. Light and electron microscopic studies of skin biopsies revealed that in pigmented areas melanin is produced by DOPA-positive melanocytes and stored in form of large single melanosomes within keratinocytes. In depigmented areas melanocytes and melanosomes are completely lacking, but a high number of indeterminated cells is present in the basal layer. Melanotic tumors from the root of the tail, the lips, the perianal region, the sholder and intestinal lymph nodes exhibited either encapsulated nodules or diffusely infiltrating melanomatous structures similar to blue nevi in the dermis. Junctional activity could never be observed. A differentiation between melanin-producing tumor cells and melanophages was difficult in light microscopy but possible according to ultrastructural characteristics.
Arch Dermatol Res 1977 Jul 21
PMID:[Comparative investigations of depigmented and melanomatous lesions in gray horses of the lipizzaner breed (author's transl)]. 90 Sep 91

By repeated uv-irradiation the quantity of all free amino acids (per surface unit) in human horny layer increase considerably. 4 different groups of substances are found by taking the relative values in mole per cent. 1. No difference for urea, threonine, serine, glutamine, tyrosine and ammonia. 2. Decrease of about 20 p.c. for glutaminic acid, citrulline, arginine, histidine. 3. Increase of about 20 p.c. for urocanic acid, aspartic acid, proline, glycine, valine, isoleucine. 4. The rest of amino acids increase about 30--50 p.c.
Arch Dermatol Res 1977 Aug 22
PMID:[Modification of relative amount of free amino acids in the stratum corneum of human epidermis by special factors of the environment. I. The influence of UV-irradiation (author's transl)]. 90 65

A 24-year-old woman noted a depigmented halo around a pigmented lesion that had been present on her abdomen since birth. The halo and the central pigmented zone showed no change during the following year. Light and electron microscopic studies disclosed an uninflamed nevus extending to the deep reticular dermis; peripherally, the basal layer of the epidermis was depigmented. These findings indicate that a halo may develop about an uninflamed nevus that does not involute, and that the nevus may show the specific histopathology of congenital nevus.
Arch Dermatol 1977 Nov
PMID:Halo congenital nevus. 93 98

Cobb syndrome consists of a vascular skin nevus associated with an angioma in the spinal cord. We describe a young man with this condition. To our knowledge, this is the 28th case reported. Cobb syndrome must be differentiated from other syndromes characterized by vascular cutaneous lesions associated with central nervous system abnormalities, such as Sturge-Weber, Osler-Weber-Rendu, Fabry-Anderson, von Hippel-Lindau, and ataxia telangiectasia.
Arch Dermatol 1977 Nov
PMID:Cobb syndrome. 93 2


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