Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Drug
Enzyme
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Query: UMLS:C0027960 (
mole
)
21,279
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The physicochemical properties of a soluble green complex obtained from the reaction of MnO2 and desferrioxamine have been investigated. The superoxide dismutase mimetic activity of this complex has been previously reported [D. Darr et al. (1987) Arch. Biochem. Biophys. 258, 351-355]. Optical spectra, titration experiments, and metal analyses are consistent with the presence of one gram-atom Mn3+ per
mole
of desferrioxamine. At least one of the hydroxamate groups is oxidized in the green complex. Reaction of
Desferal
with MnO2 in the presence of ascorbate yields a more active, pink complex. This pink complex is more stable toward EDTA, suggesting that in it all three hydroxamate groups are intact and ligated to the manganese. The physicochemical properties of these complexes were examined and structures are suggested.
...
PMID:Characterization of a superoxide dismutase mimic prepared from desferrioxamine and MnO2. 249 62
