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Query: UMLS:C0027960 (mole)
 21,279 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Most investigators find a good correlation between the morphologic and cytogenetic classification of hydatidiform moles (HM), but exceptions have been noted. We have examined three cases of HM, using chromosome marker analysis on cultured cells, human leukocyte antigen typing on cultured and uncultured tissue, and restriction fragment length polymorphism (RFLP) analysis and flow cytometry on uncultured cells. In one morphologically partial mole, only one cell population (triploid) was found and data obtained by the above-mentioned techniques were concordant. The other two moles, which were classified morphologically as complete, consisted of several cell subpopulations differing in DNA content. In both cases only one cell population was disclosed by cytogenetic investigation. In one case, the cytogenetic analysis indicated that the cultured cells were near triploid with paternal chromosomes exclusively, whereas RFLP analysis showed that maternal X chromosomal alleles were present in the mole. The present findings demonstrate that some HMs contain cellular subpopulations with differing DNA content. One explanation for discordance between cytogenetic and morphologic classification may thus be the detection of only one cell subpopulation when karyotyping.
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PMID:Genetically different cell subpopulations in hydatidiform moles. A study of three cases by RFLP, flow cytometric, cytogenetic, HLA, and morphologic analyses. 256 5

A hydatidiform mole associated with a fetus proved to be the result of twin gestation. On microscopic examination of the placenta the case was classified as a partial hydatidiform mole. Chromosomal markers were, however, consistent with a normal conception and a mole of diploid androgenetic origin. Chromosome analysis of a morphologic complete molar specimen yielded two cell lines, one consistent with a normal conception and one with diploid androgenesis. Twinning in molar specimens must therefore be considered, regardless of macroscopic appearance. The prenatal diagnosis of a coexisting fetus and molar placenta poses a real clinical problem; analyses must distinguish between a partial mole plus a triploid fetus and a normal fetus occurring with a partial or a complete mole. The distinction is important for decisions made during pregnancy and may be of prognostic significance after termination. The usefulness of chromosome marker analysis in distinguishing between the various origins is pointed out, and it is suggested that twin pregnancy with hydatidiform mole is more frequent than its description in the literature would suggest.
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PMID:Hydatidiform mole: cytogenetic marker analysis in twin gestation. Report of two cases. 346 14