Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027960 (
mole
)
21,279
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To compare gene loci considering a phylogenetic framework is a promising approach to uncover the genetic basis of human diseases. Imbalance of dopaminergic systems is suspected to underlie some emerging neurological disorders. The physiological functions of dopamine are transduced via G-protein-coupled receptors, including
DRD
5
which displays a relatively higher affinity toward dopamine. Importantly,
DRD
5
knockout mice are hypertense, a condition emerging from an increase in sympathetic tone. We investigated the evolution of
DRD
5
, a high affinity receptor for dopamine, in mammals. Surprisingly, among 124 investigated mammalian genomes, we found that Cetacea lineages (Mysticeti and Odontoceti) have independently lost this gene, as well as the burrowing
Chrysochloris asiatica
(Cape golden
mole
). We suggest that
DRD
5
inactivation parallels hypoxia-induced adaptations, such as peripheral vasoconstriction required for deep-diving in Cetacea, in accordance with the convergent evolution of vasoconstrictor genes in hypoxia-exposed animals. Our findings indicate that Cetacea are natural knockouts for
DRD
5
and might offer valuable insights into the mechanisms of some forms of vasoconstriction responses and hypertension in humans.
...
PMID:The dopamine receptor D
5
gene shows signs of independent erosion in toothed and baleen whales. 3161 87
