Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027960 (mole)
 21,279 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A total of 576 melanocytic naevi routinely excised within 1 year were analysed histologically and epidemiologically without knowledge of the clinical diagnosis. Classification into congenital melanocytic naevi (CMN, n = 82) and acquired melanocytic naevi (AMN, n = 494) was performed on the basis of the clinical history. Only a few CMN, and also some AMN, reached the lower dermis and the subcutis. An affinity of naevus cells (NC) for skin appendages was observed significantly more often in CMN than in AMN. However, no type of skin appendages was exclusively infiltrated by NC of CMN. The NC affinity for different types of skin appendages in a single naevus was characteristic of CMN. A subepidermal zone poor in NC was seen more often in CMN. The broad horizontal layer of NC within the upper dermis was rather rare in both types of melanocytic naevi. In spite of significant histological differences between CMN and AMN, the specificity and sensitivity of each criterion proved to be too low for a reliable histological diagnosis of CMN.
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PMID:[Quantitative studies of congenital and acquired nevus cell nevi]. 147 71

For binding of proteins with the membranes of liposomes, natural lipid phosphatidylinozite was proposed. First, it was activated by periodate, then in incubation with protein in alkaline medium the binding between the modifier and the protein was covalent. Liposomes with the bound protein are obtained by dialysis detergent removal. In binding of the pattern protein alpha-chymotripsin with liposomes from egg phosphatidylcholine there was reached the binding of 2,4 . 10(-3) M of protein per mole of the lipid. 70% of the enzyme immobilized on liposomes was observed to completely retain its affinity to pancreatic tripsin inhibitor. Thermostability of the immobilized enzyme was studied.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1981
PMID:[Use of phosphatidylinositol as a hydrophobic anchor for protein binding with liposomes]. 731 54

Low concordance in grading atypical (dysplastic) melanocytic nevi (AMN) has been reported, and no systematic evaluation is available. We studied 123 AMN with architectural and cytologic atypia (40 associated with atypical-mole syndrome), classified according to standard criteria by 3 independent observers. Histologic variables included junctional and dermal symmetry, lateral extension, cohesion and migration of epidermal melanocytes, maturation, regression, nuclear features, nuclear grade, melanin, inflammatory infiltrate location, and fibroplasia. AMN (43 junctional and 80 compound) were graded mild (31), moderate (61), and severe (31). AMN-severe correlated with 3 or more nuclear abnormalities (especially pleomorphism, heterogeneous chromatin, and prominent nucleolus) and absence of regression, mixed junctional pattern, and suprabasilar melanocytes on top of lentiginous hyperplasia. AMN-severe diagnostic accuracy was 99.5% using these criteria, but only the absence of nuclear pleomorphism differentiated AMN-mild from AMN-moderate. No architectural features distinguishing AMN-mild from AMN-moderate were selected as significant by the discriminant analysis. AMN from atypical-mole syndrome revealed subtle architectural differences, but none were statistically significant in the discriminant analysis. Histologic criteria can reliably distinguish AMN-severe but fail to differentiate AMN-mild from AMN-moderate. AMN from atypical-mole syndrome cannot be diagnosed using pathologic criteria alone.
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PMID:Critical analysis of histologic criteria for grading atypical (dysplastic) melanocytic nevi. 1121 3