Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027960 (mole)
 21,279 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Trichoblastoma(s) (TB) are benign neoplasms of follicular differentiation frequently found in nevus sebaceus. Many morphologic features are shared with nodular basal cell carcinoma(s) (BCC), sometimes rendering the differential diagnosis difficult. Because both neoplasms can simulate components of mature hair follicles histologically, we attempted to corroborate this by immunohistochemical examination of cytokeratins and hair keratins differentially expressed in the hair follicle. Trichoblastoma(s) and BCC showed homogenous expression of CK14 and CK17. The innermost cells of the tumor nodules in all TB and in 72% of BCC were positive for CK6hf. Using a specific CK15 antibody, 38% of TB showed a focal labeling and all BCC remained negative; 70% of TB and 22% of BCC expressed CK19. CK8 was expressed by numerous Merkel cells present in all TB but in none of the BCC examined. All type I and II hair keratins tested, (especially hHa1, hHa5, and hHa8) remained negative in all tumors examined. Trichoblastoma(s) and BCC show consistent expression of CK6hf, CK14, and CK17; variable expression of CK15 and CK19; and absence of hair keratins. This indicates a differentiation toward the outer root sheath epithelium or the companion layer and not toward the inner root sheath, matrix, or cortex.
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PMID:Cytokeratins as markers of follicular differentiation: an immunohistochemical study of trichoblastoma and basal cell carcinoma. 1180 90

Peat humic acid was fractionated by tangential ultrafiltration into six nominal molecular weight (NMW) fractions, HA5-10, HA10-20, HA20-50, HA50-100, HA100-300 and HA > 300, which were purified by dialysis using a 0.5 kDa membrane. The absorbing and emission properties of the separated fractions were compared and their ability to generate singlet oxygen under light excitation was evaluated, using furfuryl alcohol (FFA) as a singlet oxygen scavenger. The absorbance, the emission intensity, and the apparent first order rate constants of FFA loss were normalized per mole of organic carbon (a*, IF*, and k*, respectively). The fraction absorbance decreased with NMW, except for HA > 300 which was less absorbing than HA100-300. The low NMW fractions and the HA > 300 fraction generally showed lower k* and IF* values compared to the HA50-100 and HA100-300 fractions. A plot of k* versus IF* indicates that the first order rate constant of FFA photo-oxygenation increased with the intensity of fluorescence at 380, 430, and 500 nm (R2 = 0.77-0.84). This shows that the distribution of fluorescent centers among fractions paralleled that of photosensitizing centers. Plotting k* or IF* versus a* at365 nm reveals the apparent relative quantum efficiency of the different fractions. Higher values for low NMW fractions and HA50-100 are either due higher percentages of absorbing centers able to produce singlet oxygen or exhibit fluorescence or to lower quenching processes.
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PMID:Relationship between photosensitizing and emission properties of peat humic acid fractions obtained by tangential ultrafiltration. 1960 45