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 21,279 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Clinical specular microscopic examination of 17 patients with features common to the iridocorneal endothelial syndrome (including Chandler's syndrome, iris nevus syndrome, and essential iris atrophy) showed pathognomonic endothelial changes and no areas of normal endothelial mosaic. Even in those patients with minimal anterior synechiae, gross central endothelial changes could be found, suggesting that the endothelial changes are primary and not secondary to the iris-corneal adhesions. Specular microscopy of the clinically uninvolved contralateral eye in these patients revealed frequent endothelial cell pleomorphism incommensurate with the patient's age. This study also confirmed the value of the specular microscope for qualitative endothelial observations.
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PMID:Specular microscopy of iridocorneal endothelia syndrome. 735 75

The light and electron micrscopic findings in an eye enucleated from a 38-year-old woman with iris naevus (Cogan-Reese) syndrome are presented. The clinical manifestations of this disease, namely, iridic stromal matting, iridic nodule formation, and unilateral angle-closure glaucoma, appear to be secondary to an endothelial membrane on the anterior surface of the iris. The iris naevus syndrome is now thought to represent one end of the clinical spectrum of an iridocorneal endothelial syndrome which also includes those clinical entities classified previously as Chandler's syndrome and essential iris atrophy.
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PMID:The iris naevus (Cogan-Reese) syndrome: light and electron microscopic observations. 738 71

Clinical specular microscopic examination of 17 patients with features common to the irido-corneal endothelial syndrome (including Chandler's syndrome, iris nevus syndrome, and essential iris atrophy) revealed pathognomonic endothelial changes and no areas of normal endothelial mosaic. Even in those patients with minimal anterior synechiae, gross central endothelial changes could be found, suggesting that the endothelial changes are primary and not secondary to the iris-corneal adhesions. Specular microscopy of the clinically-uninvolved contralateral eye in the patients revealed frequent endothelial-cell pleomorphism incommensurate with the patient's age. This study also confirmed the value of the specular microscopy in making qualitative endothelial observations.
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PMID:Specular microscopy of irido-corneal endothelial syndrome. 744 99

Authors report of two case studies, of a man aged 39 and a woman aged 47, diagnosed and treated at Nove Zamky Infirmary Ophthalmology Ward with progressive essential iris atrophy of one eye. Based on the clinical examinations of pathogenesis authors concluded that progressive essential iris atrophy together with Chandler's syndrome and Iris-naevus syndrome represent a manifestation of pathological processes that include a corneal endothelial proliferation and dramatic iris changes. The term "primary proliferative endothelial degeneration" emphasises the pathogenic origin of corneal endothelial proliferation in all described cases. This is best described as ICE syndrome.
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PMID:[Progressive essential atrophy of the iris as a form of the iridocorneal endothelial (ICE) syndrome]. 947 89

The iridocorneal endothelial (ICE) syndrome includes progressive essential iris atrophy, the Cogan-Reese syndrome, Chandler's syndrome and mixed forms. The term ICE-S was proposed by Scheie and Yanoff in 1975 and by Yanoff in 1979. The capacity of migration of the abnormal corneal endothelial cell layer across the anterior chamber angle, and on to the anterior surface of the iris, possible on to the back surface of the iris and across the zonula fibers is responsible for corneal edema, secondary glaucoma, nevi, noduli and atrophy of the iris, and pupillary distortion. The contraction of the migrated membrane-like ICE tissue produces holes in the iris. The diseases are usually unilateral in young patients. The etiology is still not clear. Theories include membrane formation, low grade of inflammation and viral infection with Herpes simplex or Epstein-Barr virus. Glaucoma and edema of the cornea are the main therapeutic problems.
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PMID:[Iridocorneal endothelial syndrome (ICE-S): classification, clinical picture, diagnosis]. 1624 Feb 72

Iridocorneal endothelial (ICE) syndrome is a group of ocular conditions characterized by corneal proliferative endotheliopathy in which secondary corneal edema, peripheral anterior synechiae, and abnormalities of the iris stroma are the common features. The etiology remains unclear, but may be related to viral infection with Herpes simplex or Epstein-Barr virus. The pathogenesis of the ICE syndrome is believed to result from an abnormality of the corneal endothelial cells (causing corneal edema), with secondary spreading of the cells over the trabecular meshwork region (causing anterior synechiae and elevated intraocular pressure [IOP]) and across the surface of the iris (responsible for the formation of iris holes, pupillary distortion, and iris noduli). The disease complex, which includes essential iris atrophy, Chandler's syndrome, and iris nevus (Cogan-Reese) syndrome, is almost always unilateral, nonfamilial, and typically occurs in females during young adulthood. ICE syndrome is commonly progressive and frequently complicated by secondary glaucoma and corneal decompensation. In Chandler's syndrome, iris changes are less pronounced and corneal edema more frequent than in essential iris atrophy or Cogan-Reese syndrome. Glaucoma associated with ICE syndrome is often difficult to manage and is usually treated with medications and/or filtering surgery. Glaucoma filtering surgery is usually successful when done early, but may fail due to endothelialization of the fistula by the abnormal corneal endothelium.
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PMID:[Iridocorneal endothelial syndrome and glaucoma]. 1731 7


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