Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027960 (mole)
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A downfield shift of proton signals up to 9 ppm is induced in the 1H NMR spectra of juvenile hormone I (methyl 3,11-dimethyl-10,11-cis-epoxy-7-ethyl-2-trans, 6-trans-tridecadienoate) and III (methyl 10,11-epoxy-2-trans, 6-trans-farnesoate) by the lanthanide complex Eu(fod)3. A plot of induced shift vs the ratio of [LSR]/[substrate] shows a good linear correlation for the range 0.3--1.0 mole ratio. Highest shifts are induced for the protons H-10 and H-2 adjacent to the two Lewis base groups of the hormone. Resolution due to induced shift decreases for the other signals with increasing distance of protons from the two coordination sites.
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PMID:Application of lanthanide induced shifts in proton magnetic resonance spectroscopy of juvenile hormones. 14 23