Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027960 (mole)
 21,279 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A preparation of purified bovine IgG1 was found to contain 0.5 moles of Cu2+ ions per mole of protein. Scatchard analysis of the binding of Cu2+ ions to bovine IgG1 indicated the presence of 4 +/- 1 binding sites with an affinity of 2 x 10(5) M-1. Calculations indicate that in bovine plasma, IgG1 will not compete significantly with albumin for Cu2, whereas a proportion of Cu2+ may well be bound to IgG1 in colostrum. Physiological levels of Cu2+ were found to enhance the interaction between IgG1 antibody and Brucella abortus in the presence of albumin. Irrespective of whether IgG1 binds Cu2+ in vivo, it is possible that Cu2+ can influence the results of serological tests.
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PMID:A possible role of Cu2+ ions in bovine antibody-antigen interactions. 680 57

Sequence analysis of the full-length medium segment and the partial small and large segments of a hantavirus, detected by reverse transcription-PCR in lung tissues of the Chinese mole shrew (Anourosorex squamipes) captured in Cao Bang Province, Vietnam, in December 2006, indicated that it is genetically distinct from rodentborne hantaviruses.
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PMID:Newfound hantavirus in Chinese mole shrew, Vietnam. 1821 72

To determine the genetic diversity and geographic distribution of Cao Bang virus (CBNV) and to ascertain the existence of CBNV-related hantaviruses, natural history collections of archival tissues from Chinese mole shrews (Anourosorex squamipes) and Taiwanese mole shrews (Anourosorex yamashinai), captured in Guizho Province, People's Republic of China, and in Nantou County, Taiwan, in 2006 and 1989, respectively, were analyzed for hantavirus RNA by RT-PCR. Pair-wise alignment and comparison of the S-, M- and L-segment sequences indicated CBNV in two of five Chinese mole shrews and a previously unrecognized hantavirus, named Xinyi virus (XYIV), in seven of 15 Taiwanese mole shrews. XYIV was closely related to CBNV in Vietnam and China, as well as to Lianghe virus (LHEV), recently reported as a distinct hantavirus species in Chinese mole shrews from Yunnan Province in China. Phylogenetic analyses, using maximum-likelihood and Bayesian methods, showed that XYIV shared a common ancestry with CBNV and LHEV, in keeping with the evolutionary relationship between Anourosorex mole shrews. Until such time that tissue culture isolates of CBNV, LHEV and XYIV can be fully analyzed, XYIV and LHEV should be regarded as genetic variants, or genotypes, of CBNV.
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PMID:Genetic variants of Cao Bang hantavirus in the Chinese mole shrew (Anourosorex squamipes) and Taiwanese mole shrew (Anourosorex yamashinai). 2692 99