Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027960 (mole)
 21,279 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Amyloid fibrils share various common structural features and their presence can be detected by Thioflavin T (ThT). In this paper, the binding mode of ThT to insulin amyloid fibrils was examined. Scatchard analysis and isothermal titration calorimetry (ITC) showed at least two binding site populations. The binding site population with the strongest binding was responsible for the characteristic ThT fluorescence. This binding had a capacity of about 0.1 moles of ThT bound per mole of insulin in fibril form. The binding capacity was unaffected by pH, but the affinity was lowest at low pH. Notably, presence of a third binding process prior to the other processes was suggested by ITC. Binding of ThT resulted in only minor changes in the fibril structure according to the X-ray diffraction patterns, where a slightly more dominant equatorial reflection at 16A relative to the intersheet distance of 11A was observed. No change in the interstrand distance of 4.8A was observed. On the basis of our results, we propose that ThT binds in cavities running parallel to the fibril axis, e.g., between the protofilaments forming the fibrils. Such cavities have been proposed previously in insulin fibrils and several other amyloid fibril models.
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PMID:Binding mode of Thioflavin T in insulin amyloid fibrils. 1768 91

Si-Si/Si-O dehydrocoupling of hydrosilanes with alcohols (1:1.5 mole ratio), catalyzed by group VIII metallocenes Cp2M' (M' = Co, Ni) which converted to Co(O)/nickel(O) colloidal nanoparticles, produced poly(alkoxysilane)s in one-pot in high yield. The hydrosilanes include p-X-C6H4SiH3 (X = H, CH3, OCH3, F), PhCH2SiH3, and (PhSiH2)2. The alcohols include MeOH, EtOH, 'PrOH, PhOH, and CF3(CF2)2CH2OH. The weight average molecular weight of the poly(alkoxysilane)s were in the range of 600 to 8100. The dehydrocoupling reactions of phenylsilane with ethanol (1:3 mole ratio) in the presence of the nanocolloid catalyst gave only triethoxyphenylsilane as product.
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PMID:Synthesis and characterization of poly(alkoxysilane)s catalyzed by Co/Ni colloidal nanoparticles. 2035 30

Si-Si/Si-O dehydrocoupling of hydrosilanes with alcohols (1:1.5 mole ratio), catalyzed by AgNO3 which converted to Ag(0) colloidal nanoparticles, gave poly(alkoxysilane)s in one-pot in moderate to high yield. The hydrosilanes include p-X-C6H4SiH3 (X = H, CH3, OCH3, F), PhCH2SiH3, and (PhSiH2)2. The alcohols include MeOH, EtOH, (i)PrOH, PhOH, and CF3(CF2)2CH2OH. The weight average molecular weight and polydispersity of the poly(alkoxysilane)s were in the range of 1,600 approximately 8,000 Dalton and 1.4 approximately 3.5. The dehydrocoupling reactions of phenylsilane with ethanol (1:3 mole ratio) in the presence of the silver nanocolloid catalyst produced only triethoxyphenylsilane as product.
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PMID:One-pot synthesis and characterization of poly(alkoxysilane)s promoted by silver colloidal nanoparticles. 2145 76

Combinative one-pot Si-Si/Si-O dehydrocoupling of hydrosilanes with alcohols (1:1.5 mole ratio), mediated by a mixture of AgNO3-AuCl3 (100/1 mole ratio) rapidly produced poly(alkoxysilane)s in reasonably high yield. The addition of small amount of gold complex to the reaction mixture effectively accelerated the coupling reaction compared to the reaction rate with AgNO3 alone. The hydrosilanes include p-X-C6H4SiH3 (X = H, CH3, OCH3, F), PhCH2SiH3, and (PhSiH2)2. The alcohols include MeOH, EtOH, iPrOH, PhOH, and CF3(CF2)2CH2OH. The weight average molecular weight and polydispersity of the poly(alkoxysilane)s were in the range of 1,600-8,000 Dalton and 1.4-3.5, respectively. The dehydrocoupling reactions of phenylsilane with ethanol (1:3 mole ratio) in the presence of the Ag-Au complexes gave only triethoxyphenylsilane.
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PMID:One-pot synthesis and structural characterization of poly(alkoxysilane)s catalyzed by silver-gold complexes. 2364 1

One-pot Si-Si/Si-O dehydrocoupling of hydrosilanes with alcohols (1:1.5 mole ratio), promoted by a mixture of AgNO3-H2PtCl6 (150/1 mole ratio) readily gave poly(alkoxysilane)s in good yield (62-91%). The addition of small amount of platinum complex to form nanoparticles facilitated the silicon polymer formation when compared to the reaction rate with AgNO3 alone. The primary/secondary hydrosilanes [p-X-C6H4SiH3 (X = H, CH3, OCH3, F), PhCH2SiH3, and (PhSiH2)2] and alcohols [MeOH, EtOH, (i)PrOH, PhOH, and CF3(CF2)2CH2OH] were used for the reaction. The weight average molecular weight and polydispersity of the poly(alkoxysilane)s were in the range of 1,690-7,100 Dalton and 1.44-3.49, respectively. The reaction of phenylsilane with ethanol (1:3 mole ratio) using the Ag-Pt complexes produced triethoxyphenylsilane only, as expected. The reaction of phenylsilane with Ge-132 produced an insoluble cross-linked gel.
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PMID:Easy Synthesis and Characterization of Poly(alkoxysilane)s Promoted by Silver-Platinum Mixed Complexes. 2632 22