Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027960 (mole)
 21,279 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 21-year-old man had blue rubber bleb nevus syndrome: 1) hemangiomas of the skin all over the body; 2) hemangiomas of the digestive system; 3) iron-deficiency anemia. A giant mass of hemangiomas in the tranverse colon was resected surgically.
Dis Colon Rectum
PMID:Blue rubber bleb nevus syndrome: report of a case. 87 12

A 22-year-old man with blue rubber-bleb nevus syndrome is reported on. This is a rare syndrome. This patient is of particular interest because he had a combination of rare features: (1) five ileo-ileal intussusceptions each with a hemangioma acting as the lead point, were present during operation; (2) there was an angiomatous lesion of the glans penis; (3) this is the first case reported in a Chinese person. An aggressive surgical approach was used with success. Preoperative and perioperative investigations, including operative colonoscopy, were used to localize the gastrointestinal hemangiomas.
Dis Colon Rectum
PMID:Blue rubber-bleb nevus syndrome. 708 82

Taxol is a promising agent for use in ovarian cancer and other malignancies. One problem associated with taxol is its low aqueous solubility, requiring Cremophor EL (polyethoxylated castor oil) and ethanol as excipients (Diluent 12); these agents cause serious adverse effects. Liposomes containing taxol and phospholipid (in a 1:33 mole ratio, respectively) were prepared from phosphatidylglycerol and phosphatidylcholine in a 1:9 mole ratio. Antitumor effect was evaluated against Colon-26, a taxol-resistant murine tumor. Given as 1, 4, or 9 injections, free taxol given i.v. in Diluent 12 was ineffective at delaying tumor growth at doses < or = 30 mg/kg per injection (the maximum tolerated dose). In contrast, taxol-liposomes were well tolerated at doses greater than or equal to the maximum tolerated dose of free taxol and showed significant tumor growth inhibition at 10-45 mg/kg per injection.
 ...
PMID:Antitumor effect of taxol-containing liposomes in a taxol-resistant murine tumor model. 790 97