Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027960 (mole)
 21,279 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this report an attempt has been made to discuss some of the issues pertinent to myelofibrosis complicating chronic myeloproliferative disorders (CMPDs) that are significantly associated with megakaryocyte function. In this context, biochemical, clinical and particularly morphological features were reviewed. Morphological findings based on elaborate techniques were in keeping with the assumption that in chronic myeloid leukemia (1) the number of CD61-positive megakaryocytes, and in particular their precursors were the parameters most closely associated with myelofibrosis (2) an increased content of reticulin fibers in follow-up biopsies significantly correlated with laboratory data indicative of a high tumor burden (anemia, peripheral blasts, hepatosplenomegaly) and thus a more advanced stage of the disease process (3) even a slight increase in reticulin, i.e. doubling of the normal fiber density was associated with a worse prognosis independent of therapeutic regimens given (4) Dynamics of myelofibrosis was significantly influenced by treatment. In this context, calculation of the myelofibrosis progression index (MPI) revealed a higher score following interferon therapy compared with busulfan. In addition, in idiopathic myelofibrosis (5) the evolution of myelofibrosis was unpredictable and according to the MPI, progression occurred at a relatively low rate (6) proliferation and dilatation of sinusoids accompanying intravascular hematopoiesis and collagen type IV deposits were predominant features in later (fibro-osteosclerotic) stages in the course of disease (7) transmural migration of megakaryocytes demonstrated by three dimensional reconstruction revealed a mole-like tunneling through the thickened sinusoidal wall. A very careful assessment of the numerous correlations between bone marrow features and laboratory data will allow clinicians and pathologists to gain a better insight into the mutual relationships between hematological and morphological findings in CMPDs.
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PMID:Clinicopathological impact of the interaction between megakaryocytes and myeloid stroma in chronic myeloproliferative disorders: a concise update. 908 37

In this manuscript, the compact potential model for double-gate (DG) Si1-xGex/Si heterojunction tunnel field-effect transistors (TFETs) is proposed by adopting several strategies to the previous model. Compared with the control model, the enhanced model can describe the effects of additional parameters such as electron permittivity and Si1-xGex affinity, doping dependent bandgap narrowing, temperature, built-in potential change due to degenerately doping condition and energy band off-sets. The model accuracy is examined by benchmarking against to the technology computeraided design (TCAD) device simulations in terms of electrostatic potential profiles, band diagrams and minimum tunneling barrier width (Wt, min). As a result, the enhanced model accurately describes Wt, min in various gate voltages with different Ge mole fractions and gate oxide thicknesses. The DG heterojunction TFETs are regarded as one of the most promising successors to metal-oxide-semiconductor FETs (MOSFETs) as ultra-low-power logic devices, due to their high compatibility with complementary MOS (CMOS)-based integrated circuits (ICs) in terms of structures, materials and fabrication processes. The proposed enhanced model is expected to contribute for examining the TFETs circuit operation as well as understanding device physics, in depth, to extend Moore's Law.
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PMID:Compact Potential Model for Si1-xGex/Si Heterojunction Double-Gate Tunnel Field-Effect Transistors (TFETs). 2967 23