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Query: UMLS:C0027960 (mole)
 21,279 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seven cases of angioma serpiginosum were examined in our clinic during a period of 15 years. A histological study performed in six of them revealed an increased number of ectatic capillaries in the dermal papillae. One of the cases, a 31-year-old woman, was studied by electron microscopy. The dilated capillaries consisted of endothelial cells, pericytes and veil cells. Walls of capillaries showed a heavy precipitation of fine fibrillar material admixed with collagen fibers. Most vessel walls were composed of two layers. The inner layer consisted of fine fibrillar material and the outer layer consisted of bundles of collagen fibers of about 40 nm in diameter. Characteristic findings in the endothelial cells were the formation of accessory lumen or slit-like protrusion of lumen into the endothelial lining. It appears that angioma serpiginosum is not a simple telangiectasia of preexisting vessels but represents a type of capillary nevus, which has a tendency to manifest itself in the form of capillary dilation and proliferation.
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PMID:Angioma serpiginosum. 745 3

A complete ocular examination is essential for the correct diagnosis of a malignant melanoma of the choroid. The single, most important technique is indirect ophthalmoscopy associated with biomicroscopy of the fundus. Fluorescein angiography may provide additional arguments for malignancy, but with this method it is not always possible to differentiate a malignant melanoma from a suspected naevus or even a choroidal metastasis. Fluorescein angiography provides however a detailed and objective document which allows a better follow-up of suspected lesions. As with infrared angiography, choroidal vessels are more readily seen, this technique may prove to be of diagnostic importance. A- and B-scan ultrasonography are essential to precisely measure a choroidal lesion. Especially A-scan may also allow tissue differentiation. Diaphanoscopy is especially useful in the diagnosis of choroidal haemangioma. Even naevi may provide relative or absolute scotomas. The diagnostic importance of perimetry is therefore very limited. CT-scan and especially MRI are helpful in detecting extra-ocular extension. In case of atypical naevi, a close observation for potential growth is advised. Malignant melanomas of the choroid have to be differentiated from other fundus tumours, but also from inflammatory and degenerative conditions.
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PMID:Diagnosis and differential diagnosis of malignant melanomas of the choroid. 804 33

The basic fibroblast growth factor (bFGF) is an angiogenic factor and also a mitogen for epidermal keratinocytes. In order to investigate the role of bFGF in human skin we examined the distribution of bFGF immunoreactivity in normal and diseased human skin. Antigen expression was demonstrated by direct immunofluorescence staining of cryostat sections with a polyclonal anti-bFGF antibody. In normal human skin, bFGF-like immunoreactivities were observed in the basal cells, while in the case of psoriasis, positive immunoreactivities were observed in the basal cells and several supra-basal layers at rete ridges. Seborrheic keratosis and basal cell epithelioma showed diffuse immunoreactivities in the basaloid cells of the tumor. Concurrently, benign nevus cell nevus, capillary hemangioma, squamous cell carcinoma and malignant melanoma displayed negative immunoreactivities. These results suggest that bFGF is important for basal or basaloid cell proliferation.
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PMID:Immunohistochemical localization of basic fibroblast growth factor in skin diseases. 810 71

The case of a 42-year-old Sudanese man is reported who had developed hyperpigmentation of the left face and rapidly progressive right hemiparesis followed by myoclonus at the age of 30. Blue-grey hyperpigmentation was noted in the territory of the left ophthalmic, maxillary and mandibular trigeminal nerve branches, with alopecia of the right face and axilla. CT of the brain revealed left-sided paraventricular calcifications and MRI showed atrophy of the left cerebral hemisphere and mesencephalon, a calcified haemangioma in the left basal ganglia, an old infarct in the right central pons, and cerebellar atrophy. This case resembles Ota's syndrome; however, atypical distribution of the facial nevus, the epidermal location of hyperpigmentation, and the combination of vascular and degenerative cerebral malformations indicate that this is a new hitherto unreported neurocutaneous vascular syndrome.
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PMID:A new neurocutaneous syndrome possibly related to Ota's nevus. 822 56

19750 school children, ages 6 to 15 years, were examined by the authors of this study, 1,220 (6.18%) had congenital abnormalities. In this group, 4.23% were boys and 1.88% were girls. Case histories revealed inbreeding amongst the parents (families) of children with congenital malformation to be 8.9% and 8.2% for the rest of the families in this study. There were 27 different congenital abnormalities identified, with prevalence rates of 0.05/1,000 to 15.85/1,000. The most prevalent abnormalities were umbilical hernia (15.85/1000), inguinal hernia (14.50/1,000), pectus carinatum and excavatum (7.68/1,000), undescended testes (9.00/1,000 boys), congenital nevus (3.54/1,000), retractile testis (4.45/1,000 boys), pilonidal sinus (2.63/1,000), pes planus (2.28/1,000), and hemangioma (1.16/1,000). Of the 19,750 children, 70 had multiple anomalies (3.75/1,000).
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PMID:Prevalence of congenital abnormalities in Turkish school children. 824 91

Six families in which a few members, in three generations, were affected with medial telangiectatic nevus (salmon patch, stork bite, angel's kiss) on the forehead, glabella, upper eyelids, upper lip, nose, and nuchal and occipital areas are presented. This is a mild variant of lateral telangiectatic nevus (nevus flammeus, port-wine stain) that disappears in about 50 percent of patients during the first years of life. In one family, lateral telangiectatic nevus (nevus flammeus, port-wine stain) and superficial (strawberry) hemangioma coexisted with medial telangiectatic nevus. This paper discusses the familial incidence of medial telangiectatic nevus and a new modality of treatment. Moreover, the paper presents a classification of vascular malformations and proposes a new terminology.
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PMID:Familial medial telangiectatic nevus: variant of nevus flammeus--port-wine stain. 847 68

A patient with Sturge-Weber syndrome without the characteristic facial nevus presented with focal seizures which were difficult to control and borderline mental level. CT disclosed calcification in the right occipital zone. A marked decrease of the regional cerebral blood flow that extended beyond the abnormalities depicted on CT was seen by SPECT. Venous magnetic resonance (MR) angiography revealed reduction of the superficial cortical veins and prominent deep collateral venous system in the same side of the cerebral lesion. Cranial MR imaging with Gd-DTPA demonstrated the pial angioma.
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PMID:Sturge-Weber syndrome without facial nevus. 854 64

A 26-yr-old man was admitted with malaise and melena. During the physical examination, six hemangiomas were spotted on the skin, and laboratory evaluations proved the existence of severe iron deficiency anemia (Hb 2.9 g/dl). Upper endoscopy and small bowel follow-through revealed no pathology. Colonoscopy documented the presence of a blue-red cavernous hemangioma, 1 cm in diameter, at the splenic flexura. The skin and colonic lesions were typical; thus, blue-rubber-bleb-nevus syndrome was diagnosed. The patient was given blood transfusions followed by oral iron supplementation. He refused further evaluation or surgery and is still fine after a follow-up period of 6 months. Here, we present a discussion of this case, together with a detailed review of the literature.
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PMID:Blue rubber bleb nevus syndrome. 867 49

A case of Klippel-Trenaunay-Weber Syndrome (KTWS) in a 2.5-year-old girl with congenital hemihypertrophy, nevus flammeus and liver hemangioma is presented. In addition, this report describes the rare association of hemimegalencephaly with KTWS.
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PMID:Klippel-Trenaunay-Weber syndrome with hemimegalencephaly. Report of a case. 870 99

The Klippel-Trenaunay syndrome, typically characterised by the triad of cutaneous haemangioma, venous varicosities, and limb hypertrophy, may also have a formes frustes presentation, with absence of the cutaneous naevus. A case is reported in a 75-year-old woman with a presumptive diagnosis of renovascular hypertension.
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PMID:Klippel-Trenaunay syndrome. 875 12


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