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Query: UMLS:C0027960 (mole)
 21,279 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The superficial angiomas and nevi arise from the endothelial cells, the pigment-cell-system or the epidermal cells. Hemangiomas are benign tumours of the endothelial cells appearing predominantly in female newborn infants. Depending on localisation, growth and proliferation there is a tendency for spontaneous involution. For irreversible dysfunction or anatomical deformities surgical resection during the growth phase of the hemangioma is indicated. Surgery may be necessary to improve the functional and esthetic appearance after spontaneous involution causing loose residual skin. Radiotherapy of the lesion is rarely indicated. Systemic steroid therapy in cooperation with the pediatrician should be reserved only for desperate cases such as Kasabach-Merrit-Syndrome. Port wine nevi without scars can be covered with skin tanning cosmetics. Argon-Laser-Therapy is not yet so selective that healing can be achieved with certainty and without scars. Clinical progression requires surgery, especially for racemose angiectasia. Arterial embolization should only be used under special conditions, and then only as pretreatment. Lymphangiomas are mostly angiectatic processes, especially of lymphatic vascular tissue and vessels. Even large cystic lymphangiomas can be treated quite well by surgery, but operations on large diffuse invasive lymphangiomas often cause lymphedema and infection similar to erysipelas leading to pseudorecurrence. The benign malformations of the pigment cell system require clear differentiation from malignant melanoma and its precursors. Malignant melanoma develops more frequently from congenital nevi of the deep type than from other pigmented lesions. Malignant melanomas arising from giant nevi are usually diagnosed too late so that almost all patients die. Removal of giant nevi as early as possible is recommended. The epidermal malformations, too, need accurate diagnosis. Multisymptomatic syndromes such as the Basal-Cell-Nevus-Syndrome, and vascular and pigment cell abnormalities require special care.
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PMID:[Clinical aspects and therapy of lymphangiomas, hemangiomas and nevi in the area of the head and neck]. 403 Apr 13

We present a case of an 8-year-old girl, who has, since birth, developed multiple angiomatous lesions of the skin. The evolution has been progressive and eruptive, with the lesions, beginning as reddish papulae, acquiring later a verrucous appearance. The case has revealed no associated systemic symptoms nor relevant family history of any interest. The clinical picture suggests multiple hemangiomatosis. The histopathology seems to relate this disorder to verrucous hemangioma, and therefore needs to be differentiated from angiokeratotic nevi. To our knowledge, reports of a similar clinicopathological picture are not mentioned in the literature.
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PMID:Multiple eruptive verrucous hemangiomas: a variant of multiple hemangiomatosis. 404 69

The Sturge-Weber syndrome is characterized by the presence of a leptomeningeal hemangioma variably associated with a facial nevus flammeus, seizure disorder, mental retardation, hemiparesis, homonymous hemianopsia, glaucoma, and other signs and symptoms. The relationship between the cutaneous manifestations and the other features of this disorder was studied in 35 patients. We observed that all patients with the facial nevus flammeus had involvement of the upper eye lid or forehead. Bilateral cutaneous involvement was common and when present, was often associated with extensive lesions of the trunk and extremities. The distribution of the cutaneous lesions appeared to be unrelated to that of the trigeminal nerve. A subgroup of patients, the syndrome's "forme fruste," were identified. There appeared to be no relationship between the presence and extent of the cutaneous lesions and the observed seizure disorder, difficulty of seizure control, intellectual deficit, hemiparesis, homonymous hemianopsia, and intracranial calcification. Notably, the "forme fruste" patients appeared to be spared from glaucomatous involvement and from choroidal hemangioma. We will also discuss other aspects of this syndrome.
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PMID:The cutaneous manifestations of Sturge-Weber syndrome. 622 7

During a one-year period of treatment, the authors found indications for (hemangioma, tattoos, viral warts) and limits of CO2 laser therapy (nevus flammeus, keloid).
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PMID:[Experiences with the CO2 laser in dermatology]. 640 71

Eight types of telangiectases were studied by light and electron microscopy and by 3-dimensional reconstruction from photomicrographs. Five were macular: mat telangiectasia of scleroderma, generalized essential telangiectasia, nevus flammeus, and 2 macular types not previously described. Three were papular: cherry angioma, angiokeratoma (Fabry), and angiokeratoma (Fordyce). The macular telangiectases were produced by dilatation of postcapillary venules of the upper horizontal plexus. There was no evidence of neovascularization or vascular malformation. The walls of the dilated venules were thickened by the peripheral deposition of basement membrane-like material admixed with reticulin fibers. The ultrastructure and configuration of the papular telangiectases were different. The cherry angioma was produced by spherical and tubular dilatations of capillary loops in dermal papillae. Each abnormally dilated loop was connected to the neighboring loop or loops by tortuous vascular channels. The vessels in the upper horizontal plexus were not involved. Ultrastructurally, the cherry angiomas were composed of both venous capillaries and postcapillary venules whose walls were thickened in a manner identical to that observed in the macular telangiectases. The angiokeratomas of Fabry and Fordyce were also produced by vascular abnormalities predominantly involving the dermal papillae. Ultrastructurally these vessels were similar to the small collecting veins which are normally found at the dermal-subcutaneous interface. Thus, the papular telangiectases also arose by alterations of the existing microvasculature rather than by proliferation of new vessels with random anastomoses. Reconstruction of the upper horizontal plexus from normal skin showed an undulating network of arterioles and their accompanying postcapillary venules. A 3-layered plexus arranged as venules, arterioles, and venules was not found.
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PMID:Ultrastructure and three-dimensional reconstruction of several macular and papular telangiectases. 641 47

This paper is divided into four sections. In the first section we attempted to emphasise for the plastic surgeon some practical aspects of clinical diagnosis of moles. Taking into account the pathologic and dermatologic nomenclature we classified moles (naevi) as a) melanocytic naevi, b) vascular naevi, c) epithelial naevi. The second section deals with the indication for surgical treatment. Distinction is made between relative and absolute indications. We considered the cosmetic reason only as a relative indication for surgery. On the other hand we based the absolute indication on three reasons: a) Psychosocial aspects observed in patients with moles on the face. b) Risk of malignancy: there is a high risk of melanoma associated with congenital melanocytic naevi, dysplastic naevi and blue naevi; carcinomas can develop to a sebaceous naevus; basaliomas have been described in linear verrucous epidermal naevus (Schimmelpennig-Feuerstein-Mims Syndrome). c) Complications associated with location and/or the size of a mole: amblyopia results if a haemangioma on eyelid remains untreated. Kasabach-Merrit-Syndrome develops in children with large haemangiomas. In the third section we explain our reasons for not performing incisional biopsies on pigmented skin lesions and we also describe basic surgical techniques such as simple excision with primary wound closure according to RSTL, regional flaps and free grafts (full thickness graft, split thickness graft, mesh graft, composite graft). The fourth section is a short review of special techniques in the treatment of haemangiomas: electrocoagulation, cryosurgery, magnesium seeds, systemic corticosteroids, sclerosing methods and radiotherapy.
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PMID:[Diagnosis and operative treatment of nevi and hemangiomas in the area of the head and neck]. 652 83

Since January 1980, 477 patients were treated with an argon laser, 337 afflicted with vascular lesions and 140 with nonvascular lesions. Laser therapy of portwine stains gave good results in 70% of the adult patients, but it was disappointing in patients younger than 18 years of age. Other vascular lesions, such as telangiectasia, venous lake, angiofibroma, lymphangioma, and cherry angioma, were also treated with success. For the removal of tattoos the argon laser is not an optimal modality. In our experience it should only be used in skin areas, where dermabrasion cannot be performed. Therapy of epidermal nevi, xanthelasma of the eyelids, verrucae, vulgares , and sebaceous gland hyperplasia gave preliminary promising results in some patients.
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PMID:A three-year experience with the argon laser in dermatotherapy. 672 40

The Blue Rubber Bleb Nevus syndrome is a rare disease characterized by a distinctive type of hemangioma which involves the skin and the gastrointestinal tract. In the latter location, these lesions are often responsible for chronic blood loss and secondary anemia, and in rare situations may act as a leading point for an intussusception. The diagnosis of intussusception in children older than 3 or 4 yr is frequently difficult and delayed. In a child with typical skin lesions of the Blue Rubber Bleb Nevus syndrome, an acute illness with manifestations of intestinal obstruction should indicate the possibility of an associated intussusception.
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PMID:Blue Rubber Bleb Nevi as a cause of intussusception. 683 29

A 32-year-old male, who had had temporal lobe seizure for the past 10 years, was admitted to the neurosurgical institute of Tenri Hospital on March 10, 1981. Physical examination on admission revealed some memory disturbance, neuroasthenic tendency and a purplish nevus in the left foot. Plain x-ray series of the skull showed several nodular calcified lesions in the medial aspect of the left temporal lobe. Electroencephalography showed sporadic negative spikes and irregular slow waves dominant in the left anterior quadrant of the head. CT scan showed a high-density area in the left hippocampal gyrus with slight enhancement by contrast medium. Under stereotactic consideration, a left temporal osteoplastic craniotomy and total removal of the mass were performed on March 20, 1981. The histological examination proved it to be calcified cavernous hemangioma or hemangioma calcificans after Penfield and Ward (1948). Postoperative course was uneventful; even 4 weeks after surgery, electroencephalogram became normalized, and memory and anxiety scores became better. At present, in spite of decreased anticonvulsant, the patient has had no more seizure since surgery, and has returned to his business without any complaint. The authors have emphasized the necessity of active operation for hemangioma calcificans even for the one located in the depth of the dominant cerebral hemisphere. Stereotactic consideration can make the surgical risk minimize. CT scan especially with its contour plot of the images is helpful precisely to locate the lesion. For the nevus in the left foot, the biopsy was refused by the patient, which might have connection with the intracerebral cavernous angioma.
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PMID:[A case of hemangioma calcificans (author's transl)]. 704 21

A 22-year-old man with blue rubber-bleb nevus syndrome is reported on. This is a rare syndrome. This patient is of particular interest because he had a combination of rare features: (1) five ileo-ileal intussusceptions each with a hemangioma acting as the lead point, were present during operation; (2) there was an angiomatous lesion of the glans penis; (3) this is the first case reported in a Chinese person. An aggressive surgical approach was used with success. Preoperative and perioperative investigations, including operative colonoscopy, were used to localize the gastrointestinal hemangiomas.
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PMID:Blue rubber-bleb nevus syndrome. 708 82


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