Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027960 (mole)
 21,279 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The major iron-regulated protein (MIRP) was purified, from both Neisseria gonorrhoeae and N. meningitidis by selective extraction with cetyltrimethylammonium bromide followed by ion-exchange and moleculair-seive chromatography. Solutions of the purified proteins had a characteristic pink color. The overall amino acid composition of these proteins was similar, although differences were noted in the number of serine, threonine, and lysine residues. Nevertheless, the N-terminal amino acid sequence was identical through 47 residues for both the meningococcal and gonococcal MIRP. Plasma emission spectrophotometry revealed that the meningococcal 37K protein contained ca. 1 mole Fe/mole protein.
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PMID:Characterization of the major iron-regulated protein of Neisseria gonorrhoeae and Neisseria meningitidis. 313 Jul 84

Several iron-regulated proteins of Neisseria gonorrhoeae and Neisseria meningitidis have been reported. One of these, a 37,000-dalton protein is the major iron-regulated protein (MIRP) and appears to be common among all gonococcal and meningococcal isolates. This protein was purified from both N. gonorrhoeae and N. meningitidis and was found to contain approximately 1 mole of Fe /mole of protein. Sera from patients with gonococcal infections contained antibodies to the MIRP. Thus, the MIRP is expressed in vivo. The iron-binding nature of the MIRP suggests that it may have a role in iron acquisition by the pathogenic Neisseria species and, therefore, may have a function in their pathogenicity.
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PMID:A potential role for the major iron-regulated protein expressed by pathogenic Neisseria species. 314 15