Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027960 (mole)
 21,279 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Incidence of tumors and tumor-like lesions in conjunctiva and cornea seen at Juntendo University during the 13-year period from 1980 to 1992 was analysed histopathologically. There were 126 cases including 116 benign (92.1%) and 10 malignant lesions (7.9%). Pigmented nevi (32 cases) were most frequently found, accounting for 27.6% of the benign tumors and tumor-like lesions, half of which were compound nevi (16 cases). Nevi were closely followed by cysts (24 cases, 20.7%) and dermoids (15 cases, 12.9%). Carcinoma in situ (3 cases) was most frequently found, accounting for 30% of the malignant tumors (10 cases), closely followed by malignant lymphoma (2 cases), squamous cell carcinoma (2 cases), mucinous carcinoma (1 case), sebaceous gland carcinoma (1 case) and metastatic tumor (1 case). The ratio of males to females was 4:6. Age distribution of the patients was 47-92 years.
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PMID:[Incidence of tumors and tumor-like lesions in the conjunctiva and the cornea]. 770 89

A 77-year-old male having multiple small nevi over the lips, face, mucous membrane of mouth, tongue, neck and thorax was admitted to our hospital because of severe anemia. He has been diagnosed as Rendu-Osler-Weber disease (Osler's disease) since his 42 years of age. Although the stools were positive for occult blood, hematologic examination disclosed no abnormalities except for severe hypochromic and microcytic anemia. Gastrointestinal examination showed multiple stigmata in the esophagus, stomach, duodenum, and several tumors in the colon. Histological findings of biopsy specimens obtained from these tumors revealed adenocarcinomas and tubular adenomas. Surgical resection was carried out. Resected specimens showed two tumors (one is in ascending colon appeared to be 2 type carcinoma, 1.9 x 2.3 cm in size, another is in caecum, 3 type, 7.0 x 5.0 cm in size) and three Yamada-II approximately III type polyps. Pathohistologically, the tumor in ascending colon showed moderately differentiated adenocarcinoma, another one in caecum showed mucinous carcinoma, and polyps showed tubular adenomas, respectively. Unfortunately, the anemia of this case was regarded as stemming from Osler's disease, so the precise gastrointestinal examination was not performed for a long time. It should be emphasized to be faithful to the fundamentals of medical diagnosis.
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PMID:[A case of Rendu-Osler-Weber disease associated with simultaneous, multiple advanced cancers in the colon]. 770 55

We report 4 cases of a naevocellular naevus variant containing abundant amounts of mucinous matrix. The mucinous matrix was Alcian blue (pH 2.5) and Halle's colloidal iron positive and mucicarmine and PAS negative. When the blocks of tumours were cut down, regions typical of common intradermal naevi were found in all 4 cases. The differential diagnosis with mucinous carcinoma of the skin and myxoid malignant melanoma is discussed.
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PMID:Mucinous naevocellular naevi. 818 16