Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027947 (
neutropenia
)
17,527
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
granulocyte colony-stimulating factor
1329
Sep
1087
granulocyte
1003
G-CSF
630
CSF
569
cytokine
324
Pseudomonas
303
non-Hodgkin's lymphoma
269
granulocyte-macrophage colony-stimulating factor
263
She
238
GM-CSF
235
hemoglobin
225
CD4
218
interferon
202
lymphoid
189
erythroid
186
Mol
160
granulocyte colony stimulating factor
157
granulocyte-macrophage
148
CHOP
142
HLA
135
C-reactive protein
123
erythropoietin
122
HER2
122
CD8
113
X-linked
107
CD20
104
albumin
103
CD34
101
neutrophil elastase
99
AML
99
myeloperoxidase
95
epidermal growth factor receptor
94
IFN
86
tumor necrosis factor
82
topoisomerase I
82
white cell
81
Interleukin-3
79
tyrosine kinase
78
IL-6
78
Barth syndrome
76
macrophage colony-stimulating factor
76
IgA
75
alkaline phosphatase
71
NHL
67
lipopolysaccharide
67
CD11b
66
ALL
66
glycoprotein
63
TNF
60
G-CSF receptor
59
alanine aminotransferase
59
aspartate aminotransferase
58
IL-3
56
MDS
56
serum albumin
55
PEG
55
glucan
53
UGT1A1
52
gut
52
MIC
50
lactate dehydrogenase
49
megakaryocyte
48
thrombopoietin
48
glucose-6-phosphatase
47
MRI
47
B12
46
CD16
46
hormone receptor
45
SCT
45
CD18
44
interleukin-6
44
IL-1
43
Cytokine
43
IL-8
43
p53
42
interleukin-2
41
collagen
41
GSD
41
ferritin
39
TNF-alpha
39
AST
38
hairy
38
c-fms
38
tafazzin
37
LPS
37
mTOR
37
fibrinogen
37
endoplasmic reticulum
36
nodal
36
LGL
36
B19
36
EGFR
35
interferon-alpha
35
thymidylate synthase
35
prostate-specific antigen
35
vascular endothelial growth factor
35
IL-2
34
CD56
34
histone deacetylase
34
Pol
33
TAZ
33
THC
33
chemokine
33
stem cell factor
33
LDH
33
G6PC3
32
cell surface receptor
32
CDK4
32
P-glycoprotein
32
Fas
32
proteasome inhibitor
31
glucose-6-phosphate transporter
31
HAX1
31
CD57
31
CLL
31
CXCR4
31
GPT
31
MTD
30
lactoferrin
30
osteosarcoma
30
reserved
30
insulin
30
natural killer cell
30
estrogen receptor
29
Fc gamma
29
rheumatoid factor
29
CD19
29
MTX
28
IgE
28
CD33
28
T cell receptor
27
CYP3A4
27
STAT3
27
chronic renal failure
27
TMP
27
ABL
26
rhabdomyosarcoma
26
ABCB1
25
X-linked recessive
25
BID
25
interferon-gamma
25
severe combined immunodeficiency
25
BCR
25
DLT
25
PI3K
24
interferon alpha
24
CD40 ligand
24
Granulocyte-colony stimulating factor
24
cytochrome P450
24
HLA-DR
23
dihydropyrimidine dehydrogenase
23
thymus
23
transcobalamin II
23
FAB
22
Granulocyte colony stimulating factor
22
1A1
22
TCR
22
CPT
22
ceruloplasmin
22
more...
Disease
neutropenia
17527
cancer
4082
thrombocytopenia
3338
anemia
2036
tumor
1129
leukemia
995
sepsis
979
leukopenia
972
lymphoma
874
breast cancer
818
sepsis
812
acute myeloid leukemia
766
myelosuppression
724
pneumonia
707
fungal infection
550
lung cancer
546
non-small cell lung cancer
535
myelodysplastic syndrome
502
bacteremia
482
multiple myeloma
476
metastatic breast cancer
470
agranulocytosis
451
aspergillosis
438
rash
434
lymphopenia
423
metastases
397
Hodgkin's disease
396
immunodeficiency
395
AIDS
379
colorectal cancer
376
peripheral neuropathy
370
HIV
357
infectious diseases
353
carcinoma
353
hematologic malignancies
337
non-Hodgkin's lymphoma
332
Infection
331
acute lymphoblastic leukemia
315
stomatitis
309
acute leukemia
295
cytomegalovirus
269
aplastic anemia
269
graft-versus-host disease
263
gastric cancer
259
adenocarcinoma
254
chronic lymphocytic leukemia
244
ovarian cancer
242
candidiasis
241
severe congenital neutropenia
231
rheumatoid arthritis
227
pancytopenia
225
neuropathy
224
lymphocytosis
218
hypertension
212
lung carcinoma
212
squamous cell carcinoma
209
chronic lymphocytic leukemia
193
Febrile neutropenia
179
bacterial infection
168
small cell lung cancer
163
B-cell lymphoma
159
Infections
146
lymphadenopathy
142
Leukemia
141
hemolytic anemia
140
diabetes
139
systemic lupus erythematosus
138
chronic myeloid leukemia
137
measurable disease
129
Felty's syndrome
129
hand-foot syndrome
119
prostate cancer
119
mucormycosis
118
pancreatic cancer
113
vasculitis
113
eosinophilia
113
melanoma
112
fungemia
111
depression
110
epithelial ovarian cancer
105
Klebsiella
105
sarcoma
103
LGL leukemia
100
renal failure
100
SDS
98
hypogammaglobulinemia
95
influenza
94
follicular lymphoma
93
esophagitis
93
sensory neuropathy
88
glycogen storage disease
88
opportunistic infection
88
meningitis
86
dysplasia
85
arthritis
85
virus infection
84
head and neck cancer
82
heart failure
82
hepatitis
79
proteinuria
79
colon cancer
79
enterocolitis
78
residual disease
77
myopathy
77
Barth syndrome
75
autoimmune hemolytic anemia
74
tumor progression
73
liver metastases
73
congestive heart failure
72
PCP
71
cellulitis
70
cardiomyopathy
69
glioma
69
NHL
68
renal impairment
68
lupus
68
mantle cell lymphoma
67
Epstein
66
hepatitis C
65
thrombocytosis
65
hairy cell leukemia
65
cirrhosis
64
colitis
64
tuberculosis
64
autoimmune disease
63
solid tumor
63
stroke
62
interstitial pneumonia
62
hypoglycemia
61
zygomycosis
60
peritonitis
60
esophageal cancer
60
esophageal cancer
59
chronic hepatitis
59
urinary tract infection
59
primary tumor
58
endocarditis
58
respiratory failure
57
dermatitis
57
Kaposi's sarcoma
57
cystic fibrosis
56
parvovirus
56
MDS
56
hyperglycemia
56
malnutrition
56
pancreatic insufficiency
55
sinusitis
54
T-cell lymphoma
54
dehydration
54
viremia
53
childhood cancer
53
cervical cancer
53
ischemia
52
lymphoproliferative disorders
52
idiopathic thrombocytopenic purpura
52
myocardial infarction
50
renal disease
50
lupus
49
pruritus
49
osteomyelitis
49
more...
Symptom
diarrhea
1330
nausea
899
fatigue
792
vomiting
763
anorexia
345
nausea and vomiting
303
splenomegaly
229
pain
217
asthenia
182
headache
168
abdominal pain
148
myalgia
134
dyspnea
133
constipation
110
fever of unknown origin
107
arthralgia
98
cough
92
bone pain
82
seizures
77
respiratory distress
74
Ill
71
hepatomegaly
71
lethargy
69
weakness
66
chills
65
hepatosplenomegaly
60
erythema
54
hypotonia
39
decreased appetite
38
paresthesia
38
hemoptysis
33
sleepiness
28
dizziness
28
back pain
26
flushing
25
anesthesia
23
chest pain
23
ataxia
19
discomfort
19
discomfort
19
rigors
18
hypothermia
17
syncope
16
adenitis
16
tachypnea
16
insomnia
14
sore throat
13
cachexia
13
acute abdomen
13
epigastric pain
12
exhaustion
12
abdominal discomfort
11
hypoproteinemia
11
pallor
10
collapse
9
nasal discharge
9
shortness of breath
9
numbness
8
analgesia
8
low back pain
8
pachyonychia
7
acute abdominal pain
7
colic
7
cyanosis
7
hoarseness
7
tremor
7
muscle cramps
6
HSA
6
wheezing
6
tinnitus
6
night sweats
6
loss of taste
6
starvation
6
productive cough
5
non-productive cough
5
right lower quadrant pain
5
neck pain
5
abdominal cramps
5
Severe diarrhea
5
blurred vision
4
facial pain
4
paresis
4
heartburn
4
Flu-like symptoms
4
vertigo
4
dry skin
4
thinning
4
cerebellar ataxia
4
functional recovery
4
oliguria
4
dysarthria
4
dystonia
4
angina
4
dysuria
4
emaciation
3
tingling
3
anal pain
3
periorbital edema
3
hyperoxia
3
rales
3
lightheadedness
3
spasticity
3
leg cramps
3
labored breathing
3
agitation
3
apathy
3
sneezing
3
overweight
3
generalized abdominal pain
3
exertional dyspnea
3
hypertonia
3
mouth pain
3
stridor
3
otalgia
2
pelvic pain
2
ataxic gait
2
Physical findings
2
flank pain
2
Wind
2
meningism
2
polyuria
2
generalized erythema
2
generalized rash
2
hemiplegia
2
dry eye
2
chest tightness
2
livedo
2
GI irritation
2
Reticulocytosis
2
shoulder pain
2
consciousness disturbance
2
ENT
2
dark urine
2
neuralgia
2
thigh pain
2
myoclonus
2
epigastric distress
2
urinary frequency
2
leg edema
2
Gastrointestinal symptoms
2
spasm
2
physical appearance
2
hot flashes
2
neck stiffness
2
cancer pain
2
rhinorrhea
2
body pain
2
acute stress
1
ophthalmoplegia
1
bitter taste
1
testicular pain
1
right upper quadrant pain
1
dental pain
1
abnormal gait
1
tonic-clonic seizure
1
memory loss
1
adipsia
1
presyncope
1
disturbed balance
1
ketonuria
1
more...
Drug
CSF
760
G-CSF
754
Docetaxel
261
Taxol
197
CPT-11
159
Filgrastim
155
Filgrastim
135
Irinotecan
125
Dermatol
108
Taxotere
90
CTX
90
Rituximab
83
Vinorelbine
82
TTC
64
Lenalidomide
62
MDS
56
Adriamycin
56
Oxaliplatin
47
Pemetrexed
46
Fluconazole
45
CTC
43
CTC
43
AZT
42
Etoposide
41
AZT
38
Bortezomib
38
ampicillin
35
Bevacizumab
35
AmBisome
35
Posaconazole
34
Ganciclovir
34
Navelbine
34
IL-2
34
Fludarabine
32
Caspofungin
30
Gemzar
28
GEO
28
Clopidogrel
27
Micafungin
27
ADM
26
Herceptin
26
Campath
25
Campath
25
IPM
25
Amifostine
24
Itraconazole
24
Leucovorin
24
-deoxyadenosine
22
Meropenem
22
Lenograstim
22
Meropenem
21
Piperacillin
20
Ixabepilone
18
Cardiovasc
18
Trabectedin
18
IFN-gamma
17
Indomethacin
16
Asthma
16
CTX
15
CTX
15
Imatinib
14
TAC
14
Xeloda
14
Novantrone
13
Tocilizumab
13
AraC
13
VCR
13
Cetuximab
13
Trimethoprim-sulfamethoxazole
12
Erlotinib
12
Alimta
12
Ceftazidime
12
PFA
12
Prednisolone
12
Dasatinib
11
ABC
11
Everolimus
11
Clofarabine
11
Monit
11
Cremophor EL
10
IL-11
10
Prednisone
10
Paraplatin
10
Captopril
10
Leukine
9
Idarubicin
9
Valganciclovir
9
Gleevec
8
ROC
8
Nephron
8
ascorbate
8
Tacrolimus
8
EPI
8
vitamin E
8
Anidulafungin
8
Nephron
8
anti-CD33
8
Gefitinib
7
Dial
7
Acyclovir
7
Leaf
6
Trib
6
ROS
6
ARA-C
6
MAP
6
PCP
6
Spectrum
6
DM1
6
TAK
6
Fotemustine
6
MRC
6
Sorafenib
6
Revlimid
6
Biopolymers
5
Epidoxorubicin
5
Tipifarnib
5
Gel
5
Ambisome
5
NBT
5
lysine
5
Vindesine
5
Albumin
5
Cimetidine
5
Vorinostat
5
Nelarabine
5
VCR
5
Cimetidine
5
Mutagen
5
Vindesine
5
Cidofovir
4
Histamine
4
Bayer
4
Ethyol
4
Deferasirox
4
Alliance
4
DMAP
4
ADR
4
Epoetin
4
Bactrim
4
Teniposide
4
Nafcillin
4
ENT
4
Midostaurin
4
DEX
4
Aprepitant
4
Tarceva
4
Fraction
3
Mycophenolic acid
3
Heme
3
Pixantrone
3
niacin
3
Ketoconazole
3
Moxifloxacin
3
Pertuzumab
3
Mitomycin-C
3
PMPA
3
uPA
3
Pirarubicin
3
Nartograstim
3
PMEA
3
more...
Enzyme
ERK
217
alanine aminotransferase
157
peroxidase
108
aspartate aminotransferase
94
neutrophil elastase
83
focal adhesion kinase
81
alkaline phosphatase
71
lactate dehydrogenase
54
topoisomerase
47
glucose-6-phosphatase
47
topoisomerase
47
BMT
43
AST
38
thymidylate synthase
37
beta-lactamase
35
prostate-specific antigen
34
asparaginase
34
P-glycoprotein
32
MTD
30
elastase
29
UDP-glucuronosyltransferase
27
CYP3A4
27
ceruloplasmin
26
reverse transcriptase
26
mitogen-activated protein kinase
24
catalase
24
dihydropyrimidine dehydrogenase
23
CPT
22
CPT
22
CPT
22
dihydropyrimidine dehydrogenase
21
lysozyme
21
protein kinase
20
proteasome
20
creatine kinase
19
caspase-1
19
superoxide dismutase
19
dihydrofolate reductase
17
PARP
16
thromboplastin
15
thrombin
15
APC
13
NADPH oxidase
13
thiopurine methyltransferase
13
CD10
12
adenosine deaminase
12
gamma-glutamyl transpeptidase
12
NADPH oxidase
12
protein kinase C
12
acid phosphatase
12
adenosine deaminase
12
MIP
11
thymidine phosphorylase
11
RNA polymerase
11
lipase
10
ribonucleotide reductase
10
ACE
10
MDR
9
xanthine oxidase
9
DCF
9
ribonucleotide reductase
9
beta-glucuronidase
9
MEK
9
glutathione S-transferase
9
carboxylesterase
9
CD13
8
BAL
8
renin
8
methylenetetrahydrofolate reductase
8
cathepsin G
8
phosphatidylinositol 3-kinase
8
methylenetetrahydrofolate reductase
8
TdT
7
DNA methyltransferase
7
transcriptase
7
DNA polymerase
7
endonuclease
7
phosphodiesterase
7
aldehyde dehydrogenase
6
cdc2
6
trypsin
6
kinesin
6
urokinase-type plasminogen activator
6
granzyme B
6
calcineurin
6
PCP
6
NOS
6
matrix metalloproteinase 9
5
lipoxygenase
5
kallikrein
5
acetylcholinesterase
5
caspase-3
5
phosphoinositide 3-kinase
5
purine nucleoside phosphorylase
5
MAP
4
glyceraldehyde-3-phosphate dehydrogenase
4
exoribonuclease
4
luciferase
4
Alternating
4
phospholipase C
4
DHAD
4
thyroid peroxidase
4
DNA ligase
3
DNA ligase
3
cytidine deaminase
3
S-adenosylmethionine decarboxylase
3
NO synthase
3
C3 convertase
3
polo-like kinase 1
3
ATPase
3
DNase
3
tryptase
3
p100
3
tyrosinase
3
PTA
3
CEP
3
furin
3
deoxycytidine kinase
3
factor C
3
prostate-specific membrane antigen
3
farnesyltransferase
3
PAL
3
CEP
3
AOR
3
beta-galactosidase
3
farnesyltransferase
3
cholinesterase
3
aldehyde dehydrogenase
2
aldehyde dehydrogenase
2
aldehyde dehydrogenase
2
IKK
2
hexokinase
2
alcohol oxidase
2
cytochrome oxidase
2
aldehyde dehydrogenase
2
hypoxanthine-guanine phosphoribosyltransferase
2
C3 convertase
2
monoamine oxidase
2
collagenase
2
glutathione reductase
2
glucose-6-phosphate dehydrogenase
2
CPM
2
GSK
2
callose synthase
2
glucocerebrosidase
2
folylpolyglutamate synthetase
2
STK4
2
ACS
2
plasmin
2
neuraminidase
2
glutathione synthetase
2
urease
2
proteinase-3
2
flavin-containing monooxygenase
2
caspase-8
2
urease
2
DAT
2
fumarase
2
CPN
1
nicotinamide phosphoribosyltransferase
1
more...
Compound
Clin
2014
Dec
1168
DNA
452
creatinine
238
Docetaxel
212
Paclitaxel
205
5-FU
188
CPT-11
157
Gemcitabine
146
Gemcitabine
146
oxygen
132
iron
119
glucose
110
water
110
DDP
108
CBDCA
108
CBDCA
108
PEG
97
Adriamycin
91
CTX
90
His
89
copper
88
folinic acid
88
Amphotericin B
87
sodium
81
VP-16
79
acetate
78
phosphate
68
SN-38
67
Topotecan
62
AZT
62
Ara-C
61
Topotecan
61
Clozapine
61
TNF
60
PEG
57
calcium
57
Ara-C
52
MIC
50
ADR
50
Methotrexate
47
urea
45
Optimal
44
zinc
42
nitrogen
41
Vancomycin
40
sulfate
39
Phe
39
carbonate
38
Ticlopidine
36
Capecitabine
35
leucine
34
Ifosfamide
33
Levamisole
33
retinoic acid
32
methionine
32
Epirubicin
32
GPT
31
Voriconazole
30
potassium
29
tyrosine
29
6-12
28
MTX
28
TMP
27
TMP
27
TMP
27
TMP
27
ABL
26
CPT
26
iodine
26
Dexamethasone
26
DLT
26
BCR
25
arginine
25
Mitoxantrone
25
uridine
25
BCNU
25
Neo
24
CAM
24
Cardiol
23
galactose
23
CCNU
23
pyrimidine
23
Cefepime
23
pyrimidine
23
glucose-6-phosphate
23
Amifostine
22
CPT
22
Lithium
21
Mitoxantrone
21
ATP
21
L-PAM
20
L-PAM
20
Pac
20
Piperacillin
20
ADP
20
ASA
19
nitric oxide
19
EDTA
19
A 3
19
hydrogen
19
EDTA
19
Imipenem
19
CAP
18
DFS
18
Vinblastine
18
MSG
18
Hemoglobin
18
Temozolomide
18
silver
18
ethanol
18
Vincristine
17
DIC
17
ZD1694
17
TTP
16
serine
16
lysine
16
Ciprofloxacin
16
THP
15
ITP
15
THP
15
H2O2
14
Leucovorin
14
ANCA
14
cysteine
14
Hydroxyurea
14
Ceftriaxone
14
GDP
14
Wellcome
13
MMC
13
TBI
12
CO2
12
PMA
12
Prednisolone
12
Ceftazidime
12
prostacyclin
12
FK506
12
Levofloxacin
11
CAP
11
5-Aza-2'-deoxycytidine
11
Foscarnet
11
Parenteral
11
Cyclosporine
11
salt
11
Prednisone
10
Methicillin
10
SCN
10
NADP
10
A 71
10
CTAB
10
phosphorus
10
alanine
10
BAL
10
Ribavirin
10
ADP
10
ammonia
10
benzene
10
MDR
10
TOF
10
Teicoplanin
9
more...