Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027947 (neutropenia)
 17,527 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Neutrophil specific antigens (NA) are expressed exclusively on human neutrophils and were identified using alloantibodies. Neutrophil specific antigens are polymorphic, and several of them (NA1, NA2, NB1, NB2, NC1, ND1, NE1, and 9A), are thought to define genes at different loci. Feto-maternal incompatibility of NA has resulted in alloimmune neonatal neutropenia. Also, NA are the target antigens for autoantibody production in infants and young children with autoimmune neutropenia of infancy and chronic idiopathic neutropenia in adults. Autoimmune neutropenia can occur secondary to several other diseases, including AIDS. Numerous assays are useful in detecting granulocyte antibodies in patients with neutropenia. Among these assays, granulocyte agglutination (GA) and granulocyte immunofluorescence (GIF) are available in some clinical laboratories. Both IgG and IgM agglutinins are detected by GA: in addition, IgG, IgM, and IgA are detected by GIF. Immune neutropenia (IN) occurs in all age groups. Originally thought to be rare, IN is being increasingly recognized in recent years. Further investigations should lead to a greater understanding of the role of NA in immune neutropenias and to identify as yet unknown NA specificities. With the availability of reproducible and sensitive assays to detect granulocyte antibodies and the increasing knowledge and understanding of various disease aspects of IN, proper diagnosis and appropriate clinical management are being applied.
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PMID:Neutrophil antigens and antibodies in the diagnosis of immune neutropenias. 265 24

NA1, NA2, NB1, NB2, NC1, and NE1 are a group of antigens specifically expressed on neutrophils. Antibodies against neutrophil-specific antigens are involved in alloimmune neonatal neutropenia (ANN), autoimmune neutropenia (AIN), and transfusion-related acute lung injury (TRALI). We investigated the frequencies of NA1, NA2, NB1, and Mart antigens in 105 healthy Korean blood donors (65 males, 40 females) by the granulocyte indirect immunofluorescence test (GIFT) employing flow cytometry. Antigen and gene frequencies were: NA1, 0.78 and 0.53, respectively; NA2, 0.75 and 0.50, respectively; and NB1, 0.86 and 0.62, respectively. The Mart antigen was positive in all 105 subjects included in this study. The proportions of NB1-positive neutrophils among NB1-positive individuals were variable with a mean value of 72.0 +/- 20.2% (range, 27-100%). Differences in the frequency of the NA1 antigen have been reported between Asian and Caucasian populations. Our data support this variation. In addition, it was found that the frequency of the NA1 antigen in Koreans is significantly lower than in Japanese and Chinese populations (p < 0.05).
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PMID:Frequency of neutrophil-specific antigens among Koreans using the granulocyte indirect immunofluorescence test (GIFT). 1538 93