Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027947 (
neutropenia
)
17,527
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A female patient with congenital cyclic
neutropenia
was presented. The cycle of
neutropenia
and the duration of
neutropenia
of less than 500/microliters was approximately three weeks and two weeks, respectively. There were also oscillations of monocytes and eosinophils with the peak level at the neutropenic phase. The severity and incidence of infections tended to diminish when the patient was pregnant. There were no abnormalities of lymphocyte subpopulations including CD4, CD8, CD4/CD8 ratio, and CD16. Administration of the immunomodulator ubenimex (
Bestatin
), 30 mg/day, reduced the severity of infections during the neutropenic periods, although the cyclic of
neutropenia
was not altered.
...
PMID:Ubenimex treatment in congenital cyclic neutropenia. 226 63
