Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027947 (neutropenia)
 17,527 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fourteen patients with hemopoietic and solid malignancies underwent dose-intensive chemotherapy, followed by haemopoietic stem cell grafting. Granulocyte apoptosis was assessed as nuclear chromatin condensation, after ex vivo incubation of blood samples for 3 h, followed by Acridine Orange staining. Myeloablative therapy caused time-dependent increase in ex vivo granulocyte apoptosis, being maximal at D+7 to D+9, thus preceding the development of neutropenia (nadir values on D+13 to D+15). In vivo administration of G-CSF (Neupogen) resulted into short-term decrease in apoptotic granulocyte numbers. Hence, granulocyte apoptosis is an important factor of therapy-induced leukopenia and could be modified by the G-CSF treatment.
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PMID:Enhanced ex vivo apoptosis of peripheral granulocytes is a sufficient factor of neutropenia following myeloablative chemotherapy. 1078 85