Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027947 (neutropenia)
 17,527 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Luminol-dependent chemiluminescence of resting and opsonized zymosan-activated neutrophils isolated from the peripheral blood was determined in 10 chronic uremic patients during early period of hemodialysis without verapamil or preceded by verapamil injection. Verapamil was found to diminish depression of neutrophil chemiluminescence both at rest and following activation with opsonized zymosan. The drug also diminished transient hemodialysis neutropenia. The results seem to indicate that verapamil may exert beneficial effects on inflammatory reactions induced by hemodialysis in chronic uremics.
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PMID:Effect of verapamil on chemiluminescence of peripheral blood neutrophils during hemodialysis in chronic uremic patients. 261 99

A promising drug, palbociclib, received accelerated approval as a first line treatment when used with the aromatase inhibitor, letrozole, for postmenopausal women with hormone receptor positive advanced or metastatic breast cancer. We report a case of a patient who presented with febrile neutropenia, grade 3 stomatitis with lip swelling, periorbital edema, and transaminitis while on palbociclib and verapamil. Labs normalized upon discontinuation of verapamil and our patient was able to continue treatment with palbociclib and letrozole. Verapamil's inhibition of both permeability-glycoprotein (P-gp) and CYP3A4 is suspected to have led to the adverse side effects seen in our patient.
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PMID:Verapamil as a culprit of palbociclib toxicity. 2952 51