Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027947 (neutropenia)
 17,527 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A population of patients with agranulocytosis admitted to a general hospital over a period of 12 yr was studied retrospectively in order to determine the causes of the disease. Of the 48 cases identified, 31 (65%) had drug-induced neutropenia, whereas 17 (35%) had chronic neutropenia unrelated to the use of drugs. Eight patients had an underlying hematological malignancy. Patients with agranulocytosis not induced by drugs more frequently had hepatomegaly, splenomegaly, enlarged lymph glands, or thrombocytopenia together with severe anemia. In contrast, drug-induced agranulocytosis was more severe, with a higher incidence of positive blood cultures, low cellularity of initial bone marrow aspirates, and a shorter duration of neutropenia. Dipyrone and methimazole were the drugs most commonly associated with agranulocytosis. Dipyrone was probably the causative agent in two of the seven drug-induced fatalities. In view of these findings, and those of several previous reports, it is proposed that the use of dipyrone in Israel be severely restricted or discontinued altogether.
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PMID:Causes of agranulocytosis in a hospital population: identification of dipyrone as an important causative agent. 685 18

Hospital records of 256 patients discharged with a diagnosis of agranulocytosis during 1973-78 in the Stockholm County region were reviewed. In 84 cases the neutropenia was probably caused by drugs other than cytostatics, giving an annual incidence of 0.009%. The commonest drugs were sulfonamides, thyreostatics and thenalidine. Metamizole (Dipyrone), previously the commonest cause of drug-induced neutropenia in Sweden, has not been marketed since 1973 and, as a result, only two cases were seen (the drug had been obtained abroad). Comparison of the number of cases of neutropenia with drug sales showed the highest frequency for thenalidine, followed by thyreostatics, penicillamine and sulfonamides, in that order. Only about 35% of the cases had been reported to the authorities. Nine (11%) of the patients died. It is concluded that the pattern of drugs causing neutropenia has changed in Sweden since the studies from the latter half of the 60s and that early detection of this side-effect requires directed and continuous follow-up studies.
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PMID:Drug-induced neutropenia--a survey for Stockholm 1973-1978. 718 May 77