Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027819 (neuroblastoma)
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Human Gene/Protein
Mol 1950
Sep 1852
NBS 1277
MYCN 1218
caspase-3 862
p53 708
amyloid precursor protein 614
N-myc 565
rhabdomyosarcoma 512
Bcl-2 494
ATP 478
AMP 456
endoplasmic reticulum 410
olfactory 360
nerve growth factor 307
tyrosine hydroxylase 285
adenylate cyclase 281
acetylcholinesterase 270
cytokine 263
cytochrome c 256
ERK1 254
osteosarcoma 249
prion 248
ERK 245
insulin 242
prion protein 238
MAPK 236
PrP 234
glycoprotein 233
GTP 224
proteasome 223
axonal 219
GSH 218
tyrosine kinase 216
PI3K 213
polypeptide 212
p38 207
p21 202
ubiquitin 200
opioid receptor 195
ROS 189
NMR 189
fused 187
all-trans 186
mTOR 183
lactate dehydrogenase 181
superoxide dismutase 179
caspase-9 177
brain-derived neurotrophic factor 176
bradykinin 173
AKT 172
muscarinic receptor 171
neuron-specific enolase 163
histone 161
amyloid beta 160
caspase-8 158
SDS 157
tumor necrosis factor 157
tau protein 157
interferon 153
MPP 153
PARP 150
LAN 149
JNK 147
phosphatase 146
ALK 145
MYC 143
synuclein 140
PKC 139
neurotrophin 138
ATPase 136
calmodulin 134
TNF 134
adenylyl cyclase 129
catalase 129
collagen 128
proto-oncogene 128
membrane-bound 127
ADP 125
extracellular signal-regulated kinase 125
fibronectin 125
synaptophysin 125
histone deacetylase 125
MRI 120
Rho 118
vascular endothelial growth factor 117
phosphatidylinositol 3-kinase 117
MEK 116
vimentin 116
BACE1 116
APP 111
lipopolysaccharide 111
enolase 111
GSK 110
alpha-synuclein 110
c-myc 108
Gen 107
choline acetyltransferase 106
sodium channel 106
UTR 106
LDH 106
neural cell adhesion molecule 104
calpain 104
ferritin 103
c-Jun 103
somatostatin 102
glial fibrillary acidic protein 100
ACS 100
threonine 100
non-Hodgkin's lymphoma 100
IL-6 100
receptor tyrosine kinase 99
CD56 99
nitric oxide synthase 98
insulin-like growth factor 98
annexin V 98
anaplastic lymphoma kinase 98
lymphoid 97
cyclin D1 97
microtubule-associated protein 96
Sp1 96
calcium channel 95
GTPase 95
IFN 95
neuropeptide Y 94
CHP 93
AP-1 92
LC3 91
NGF 90
mitogen-activated protein 90
5-HT3 receptor 90
ras 89
phosphodiesterase 89
HEK 87
c-fos 85
lectin 85
Nrf2 84
epidermal growth factor 82
CREB 82
GAP-43 82
HLA 81
heme oxygenase-1 80
inducible nitric oxide synthase 78
Leu5 77
She 77
SMS 77
beta 1 77
bcl-2 75
MDM2 75
HT3 75
p65 75
catenin 75
Phox2b 74
IFN-gamma 73
colon carcinoma 73
STAT3 73
erythroid 72
interleukin-2 72
peroxidase 71
IGF-I 71
more...
Disease
neuroblastoma 27800
tumor 5855
cancer 5814
Neuroblastoma 2227
Neuroblastoma 2227
Alzheimer's disease 1740
glioma 1346
NBS 1277
Parkinson's disease 867
metastases 854
melanoma 624
tumor growth 605
carcinoma 577
WT1 556
leukemia 541
rhabdomyosarcoma 509
solid tumor 501
tumorigenesis 487
lymphoma 481
Ewing's sarcoma 452
childhood cancer 451
pheochromocytoma 427
glioblastoma 360
primary tumor 352
breast cancer 348
retinoblastoma 340
sarcoma 324
tumor progression 301
osteosarcoma 290
pertussis 276
medulloblastoma 274
astrocytoma 267
ganglioneuroma 263
Hodgkin's disease 226
hepatocellular carcinoma 222
GSH 218
adenocarcinoma 208
metastatic neuroblastoma 201
acute lymphoblastic leukemia 198
lung cancer 180
dementia 176
metastatic neuroblastoma 163
scrapie 163
ischemia 157
SDS 157
lung carcinoma 151
primitive neuroectodermal tumor 149
amyotrophic lateral sclerosis 146
aggressiveness 139
stroke 139
prostate cancer 138
herpes simplex 134
hepatoblastoma 130
MCF 130
acute myeloid leukemia 130
primitive neuroectodermal tumor 129
teratoma 126
multiple myeloma 124
hypertension 121
renal cell carcinoma 121
non-Hodgkin's lymphoma 119
depression 118
rabies 114
carcinogenesis 114
cholera 109
minimal residual disease 107
plaque 107
esthesioneuroblastoma 107
HIV 105
squamous cell carcinoma 101
diabetes 100
PNET 98
residual disease 95
cognitive impairment 94
schizophrenia 90
virus infection 89
schwannoma 89
brain tumor 86
Huntington's disease 85
encephalitis 85
colorectal cancer 81
cold 80
colon cancer 79
neuropathy 79
immunodeficiency 77
SMS 77
parkinsonism 77
ovarian cancer 76
paraganglioma 75
cerebral ischemia 74
carcinoid 73
ATM 72
small cell lung cancer 71
pediatric solid tumor 69
embryonal tumor 68
bone metastases 67
thrombocytopenia 64
meningioma 63
oligodendroglioma 62
SCID 60
encephalopathy 60
anemia 59
non-small cell lung cancer 58
acute promyelocytic leukemia 57
acute leukemia 56
Burkitt's lymphoma 55
Wright 55
medullary thyroid carcinoma 54
infectious diseases 54
glioblastoma multiforme 53
liver metastases 53
peripheral primitive neuroectodermal tumor 52
cytomegalovirus 52
epilepsy 52
fibrosarcoma 51
myelosuppression 50
ependymoma 50
epithelial ovarian cancer 50
West 48
Evans 48
neurological disease 47
gastric cancer 47
Infection 47
chronic myeloid leukemia 46
Japanese encephalitis 46
aggression 45
pancreatic cancer 44
B-cell lymphoma 44
obesity 43
sepsis 43
bipolar disorder 42
hemangioma 42
embryonal carcinoma 41
Down syndrome 41
HCG 41
adenoma 41
bone marrow metastases 40
Langerhans cell histiocytosis 40
MRT 40
multiple sclerosis 39
Blocking 38
cervical cancer 38
CNS tumors 37
tumor angiogenesis 37
Creutzfeldt-Jakob disease 37
graft-versus-host disease 37
Beckwith-Wiedemann syndrome 36
PNET 36
recurrent neuroblastoma 35
sepsis 35
mental retardation 35
Horner's syndrome 35
adrenocortical carcinoma 35
neutropenia 35
measles 34
chondrosarcoma 34
mental retardation 34
neuroendocrine tumor 33
embryonal rhabdomyosarcoma 33
neurofibroma 33
more...
Symptom
pain 185
ataxia 105
myoclonus 103
starvation 75
seizures 72
collapse 62
anesthesia 50
vomiting 46
hepatomegaly 44
headache 44
diarrhea 43
analgesia 37
respiratory distress 35
weakness 34
nausea 28
abdominal pain 24
functional recovery 24
hypothermia 22
bone pain 22
cerebellar ataxia 19
memory loss 18
nausea and vomiting 18
dystonia 17
tremor 16
anosmia 15
back pain 14
dyspnea 14
hypotonia 13
discomfort 13
discomfort 13
exhaustion 12
fatigue 11
cough 11
fasciculation 10
anorexia 10
insomnia 9
rhinorrhea 9
pallor 9
hepatosplenomegaly 9
constipation 9
arthralgia 8
agitation 8
facial pain 8
lethargy 7
ENT 7
hyperoxia 7
chest pain 7
splenomegaly 7
HSA 6
bradykinesia 6
paresthesia 6
stridor 6
sleepiness 6
flushing 5
erythema 5
numbness 5
thinning 5
dizziness 5
tachypnea 4
myalgia 4
polyuria 4
hemoptysis 4
acidity 4
cachexia 4
polydipsia 4
nasal congestion 4
nasal discharge 4
cyanosis 4
DNA marker 4
neurological disability 4
paresis 4
bitter taste 4
Fluctuation 4
urinary frequency 3
Cushingoid 3
wheezing 3
paraparesis 3
spasm 3
chorea 3
masculinization 3
Respiratory symptoms 3
incoordination 3
Cushingoid 3
low back pain 3
dysuria 3
rundown 3
torticollis 3
vertigo 2
acute abdominal pain 2
asthenia 2
flank pain 2
hypercapnia 2
acute pain 2
Neuropathic pain 2
chills 2
stigma 2
hemiplegia 2
twitching 2
adenitis 2
hip pain 2
cancer pain 2
shortness of breath 2
exertional dyspnea 2
chronic constipation 2
ophthalmoplegia 2
dysarthria 2
syncope 2
acute stress 2
productive cough 2
Ill 2
hypoproteinemia 2
tonic-clonic seizure 2
spasticity 2
Spots 1
Mills 1
retching 1
Halo 1
loin pain 1
Severe diarrhea 1
sore throat 1
regurgitation 1
Hudson 1
periorbital edema 1
Opposition 1
General symptoms 1
prostration 1
shoulder pain 1
arm weakness 1
tingling 1
Bloody nipple discharge 1
distraction 1
Cullen's sign 1
eds 1
Bryant's sign 1
overweight 1
hyperemesis gravidarum 1
partial seizure 1
Scratch 1
delayed language development 1
Paroxysmal hypertension 1
acute abdomen 1
neck pain 1
orthopnea 1
sneezing 1
monoplegia 1
Blanching 1
persistent cough 1
Welt 1
apathy 1
stomach pain 1
Bryant's sign 1
general problem 1
oliguria 1
Psychiatric symptoms 1
skin irritant 1
drooling 1
body pain 1
intestinal bleeding 1
intention tremor 1
otalgia 1
more...
Drug
ROS 189
Retinoic acid 137
lysine 131
CSF 81
IFN-gamma 71
ascorbate 68
IL-2 67
Ethanol 62
MAP 58
caffeine 53
Gel 51
CTX 47
vitamin E 45
p75 40
Parkin 38
Parkin 38
ICI 36
Adriamycin 32
G-CSF 30
R-gene 30
Dermatol 30
NADH 30
KAN 29
Forskolin 28
Spectrum 26
Nephron 26
DNase I 25
TTC 24
Glutathione 23
CPT-11 22
Asn 22
ABC 22
Etoposide 21
Taxol 18
ENT 18
CAM 18
CTX 18
CTX 18
Cardiovasc 17
BoNT/A 16
THF 16
9-THC 15
CoCl2 15
VCR 15
Arsenic trioxide 15
HCH 15
CoCl2 15
Lovastatin 15
Isotretinoin 14
VCR 14
Monit 14
EPA 13
ADM 13
Bortezomib 13
ETS 13
Leaf 13
Mutagen 12
Vitamin E 12
NLF 12
NAG 12
G418 12
Heme 12
NVP 12
EE2 11
Portal 11
lactose 11
ETA 11
Sodium nitroprusside 11
BH4 11
Bupivacaine 10
Rasagiline 10
DFP 10
-deoxyadenosine 10
IFN-beta 10
uPA 10
MRC 10
citric acid 9
Angiotensin II 9
Atropine 9
ID2 9
Activin 9
Albumin 9
Estrogens 9
L-tyrosine 9
Irinotecan 8
Imatinib 8
TAT 8
CaCl2 8
CaCl2 8
CDP 8
Retinoic Acid 8
Vitamin A 8
CaCl2 8
Clonidine 7
TAC 7
Emodin 7
Phenytoin 7
CER 7
Emodin 7
Capsicum 7
Nitric Oxide 7
Gleevec 7
pyridoxal phosphate 7
Sorafenib 7
Alanine 7
AMC 6
ALA 6
Ouabain 6
Pravastatin 6
Ginseng 6
Apomorphine 6
FAD 6
Amifostine 6
NH3 6
Indomethacin 6
DHT 6
ROC 6
Rosiglitazone 6
Scopolamine 6
DHT 6
Amiloride 5
Theophylline 5
linolenate 5
Ranitidine 5
Pronase 5
Bevacizumab 5
Propofol 5
nitroglycerin 5
Simvastatin 5
RFP 5
Vorinostat 5
Donepezil 5
Cilostazol 5
Meth 5
BLM 5
ADR 5
PCP 5
Liraglutide 5
Amiloride 5
Glide 5
IL-1ra 5
CCL 5
ZnO 5
Pramipexole 4
ARA-C 4
Fentanyl 4
PTH 4
GEO 4
Prozac 4
Fluorescein 4
Zonisamide 4
Fluorescein 4
CTC 4
Vitamin B 4
Fipronil 4
CPM 4
Herceptin 4
DMSA 4
Sodium valproate 4
AraC 4
more...
Enzyme
mitogen-activated protein kinase 870
ERK 736
caspase-3 670
protein kinase 584
protein kinase C 531
luciferase 356
acetylcholinesterase 299
adenylate cyclase 282
tyrosine hydroxylase 275
proteasome 225
superoxide dismutase 224
lactate dehydrogenase 197
focal adhesion kinase 193
PARP 178
MEK 173
phospholipase C 170
catalase 167
MPP 153
ATPase 152
caspase-9 139
reverse transcriptase 128
GSK 122
complex I 122
caspase-8 121
phosphatidylinositol 3-kinase 118
enolase 113
calcineurin 110
choline acetyltransferase 109
ACS 102
trypsin 99
peroxidase 93
phosphodiesterase 91
cholinesterase 90
neuraminidase 83
monoamine oxidase 79
AMP-activated protein kinase 75
thrombin 69
glutathione peroxidase 68
P-glycoprotein 68
chloramphenicol acetyltransferase 66
CD10 65
cdc2 65
RNA polymerase 64
RNase 64
RNase 62
AMPK 62
phosphoinositide 3-kinase 61
guanylate cyclase 58
ornithine decarboxylase 55
MAP 55
glutathione S-transferase 53
succinate dehydrogenase 52
CaMKII 51
beta-secretase 48
topoisomerase 47
NO synthase 47
phospholipase A2 44
topoisomerase 44
NQO1 42
glyceraldehyde-3-phosphate dehydrogenase 42
transglutaminase 41
proteinase K 39
thymidine kinase 39
beta-galactosidase 37
alkaline phosphatase 36
NADPH oxidase 36
glyceraldehyde-3-phosphate dehydrogenase 36
NADPH oxidase 35
protein phosphatase 2A 34
caspase-1 34
glyceraldehyde-3-phosphate dehydrogenase 33
MDP 32
AMPK 31
glyceraldehyde-3-phosphate dehydrogenase 31
glyceraldehyde-3-phosphate dehydrogenase 31
phospholipase D 31
renin 30
sialidase 30
transcriptase 30
PDE 29
dopamine beta-hydroxylase 29
cytochrome oxidase 28
DNA polymerase 27
lipoxygenase 27
urokinase-type plasminogen activator 26
NOS 25
glutathione reductase 25
kinesin 24
hypoxanthine-guanine phosphoribosyltransferase 24
ribonuclease 23
ribonuclease 23
pyruvate dehydrogenase 23
cathepsin D 22
caspase-2 22
collagenase 21
tyrosinase 21
GD3 synthase 21
heme oxygenase 21
BMT 21
caspase-2 21
lipase 20
neuropathy target esterase 20
sialyltransferase 20
sialyltransferase 20
pyruvate dehydrogenase 20
pyruvate dehydrogenase 20
sialyltransferase 20
cathepsin B 20
acid phosphatase 19
GRK2 18
plasmin 17
tissue plasminogen activator 17
DNase 17
hexokinase 17
adenosine deaminase 17
adenosine deaminase 17
botulinum neurotoxin 17
demethylase 17
lysozyme 16
aconitase 16
chymotrypsin 16
PKG 16
glucose-6-phosphate dehydrogenase 15
PDK1 15
MDR 15
DNA methyltransferase 15
gamma-glutamylcysteine synthetase 15
glucosylceramide synthase 15
endonuclease 14
ACE 14
thioredoxin reductase 14
pyruvate kinase 14
ribonucleotide reductase 14
ribonucleotide reductase 14
alanine aminotransferase 14
diaphorase 14
creatine kinase 14
CD13 14
ricin 13
PI-PLC 13
prolyl endopeptidase 13
caspase-4 13
MMP 13
APC 12
S1 nuclease 12
histone acetyltransferase 12
kallikrein 12
peroxiredoxin 12
deaminase 12
neutral sphingomyelinase 12
PAM 12
firefly luciferase 12
caspase-4 12
ATP synthase 11
PNGase F 11
sphingosine kinase 11
aromatic L-amino acid decarboxylase 11
5'-nucleotidase 11
caspase-6 11
MEKK1 11
more...
Compound
DNA 2435
Dec 1925
calcium 1525
oxygen 1306
NBS 1277
retinoic acid 1163
sodium 861
Clin 859
cAMP 597
ATP 478
AMP 473
tyrosine 463
MTT 429
glucose 426
acetate 373
hydrogen 358
water 352
leucine 320
nitric oxide 309
phosphate 294
glutamate 273
iodine 256
iron 256
sulfate 248
GSH 235
GSH 235
serine 233
cysteine 229
GTP 226
bromide 212
potassium 199
ethanol 199
prostaglandin E1 197
zinc 195
copper 193
cGMP 189
arginine 185
lysine 182
H2O2 181
SDS 167
threonine 165
methionine 164
GM1 162
noradrenaline 160
alanine 157
MPP 153
MPP 153
Neuronal 141
TNF 134
ADP 131
galactose 129
Phe 126
ADP 125
ADP 125
nitrogen 121
5-HT 117
MEK 114
manganese 109
N-acetylcysteine 107
Gly 107
NH2 102
ACS 101
ACS 100
Asp 98
His 98
MPTP 96
PEG 95
COS 94
salt 92
glutamine 88
tryptophan 88
VMA 86
ammonium 82
NAD 80
Mg2+ 79
DMSO 74
aluminum 72
tryptophan 72
cadmium 71
Adriamycin 71
GM3 71
urea 70
tryptophan 70
tryptophan 70
GABA 69
nickel 68
GABA 68
MDA 67
silver 66
proline 66
cobalt 66
L-DOPA 66
Insulin 66
creatinine 65
Carbachol 65
ADP-ribose 64
Dopamine 62
SOA 61
HVA 60
GM2 59
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 59
mercury 58
THP 57
GD3 56
DDP 56
THP 56
caffeine 54
NAD 54
pyrimidine 53
PEG 53
methanol 53
GDP 53
MAP 53
pyrimidine 53
NMDA 49
VP-16 48
Curcumin 47
aldehyde 47
CTX 47
TOF 47
TPA 47
TPA 46
Ins(1,4,5)P3 46
ACh 46
Triton X-100 45
ADR 45
gamma-aminobutyric acid 45
boron 44
glycerol 44
guanidine 44
pyridine 44
EDTA 43
Glutamate 43
CAT 42
CAT 42
CAT 42
acrylamide 42
EDTA 42
aldehyde 42
Ile 41
dUTP 41
nicotinamide 41
diacetate 39
N-(4-hydroxyphenyl)retinamide 39
glutamic acid 37
Bradykinin 37
HCl 37
salicylic acid 37
DAMGO 36
ICI 36
DEAE 36
GMP 36
PMA 35
homocysteine 35
selenium 34
CO2 34
Lead 34
ethyl acetate 33
uridine 33
acetic acid 33
more...