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Query: UMLS:C0027819 (neuroblastoma)
 27,800 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The results of MRI and MIBG scintigraphy performed on the spine of 14 children with neuroblastoma are reported. In 6 cases of diffuse spinal bone marrow tumor infiltration, diagnosis is easier with MIBG scintigraphy than with MRI. In 5 cases, MRI detected hyposignal of the vertebral body without any spinal abnormality on MIBG scintigraphy. A discussion of the reasons for negative MIBG scintigraphy is presented and in these 5 cases, it is suggested that a lateral view of MIBG scintigraphy and HMDP-Tc99m scintigraphy may be performed, even vertebral body biopsy in order to assess bone marrow tumoral infiltration.
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PMID:Value of MRI and MIBG-I123 scintigraphy in the diagnosis of spinal bone marrow involvement in neuroblastoma in children. 143 70

The use of GD-DTPA was introduced recently for MR imaging of the body. This paper presents our experience with GD-DTPA enhanced MRI in the evaluation of neuroblastoma in children. The characteristics of the tumor-enhancement are described, its contribution to the diagnosis and the follow-up of this disease are discussed.
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PMID:Neuroblastoma: evaluation with contrast enhanced MR imaging. 181 77

Targeting of radioactivity to tumors using antitumor antibodies is evolving from a laboratory curiosity toward a practical diagnostic and therapeutic technique that promises widespread benefits for many common human cancers. The development of the hybridoma technique by Kohler and Milstein for producing monoclonal antibodies is probably the single most important contribution to the development of this field. A large array of monoclonal antibodies against many human tumors have been created and labeled with a variety of radioisotopes; 110 clinical trials have been identified from the literature between the interval of 1978 to the present. These studies are beginning to form the basis for certain conclusions regarding likely benefits for certain combinations of antitumor antibodies and isotopes in specific instances of clinical management in patients with malignant neoplasms. For example, in melanoma, lymphoma, neuroblastoma, and colorectal malignancies, radiolabeled antibodies have demonstrated occult tumors, which could not be disclosed with conventional methodologies. Radioimmunotherapy of malignant lymphoma is achieving durable remissions in patients who have failed conventional forms of therapy. For the most part, these advances have been achieved through intelligent application of known principles of immunochemistry, imaging physics, and tumor immunology. Progress has been slow but steady. In a few instances, the term "magic bullet" is warranted in describing the targeting of a particular radiolabeled antibody to a human tumor. I-131, 3-F8, an IgG3 against the GD2 antigen of neuroblastoma, which was introduced by Cheung, and In-111 T-101, against the CD5 antigen of T-cells, which was developed by Royston, stand out because of the consistency and high concentration of radioactive targeting to human tumors in clinical trials. If certain technical innovations fulfill their initial promise, the future will be bright for radioimmunologic methods of diagnosis and therapy. Genetic engineering will permit the development of "humanized" antibodies with biologic properties that favor tumor localization. New chemical approaches will broaden the range of isotopes available as diagnostic and therapeutic radiolabels. Application of modern imaging methodologies, such as positron emission tomography (PET), will detect more lesions of smaller size and permit quantitative imaging for dosimetry considerations. Greater speed and ease of use of computerized work stations will lead to the broader application of fusion imaging in which radioantibody images will be viewed simultaneously with TCT or MRI for better anatomic correlation of abnormal sites of antigen-reactive tumor deposits.
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PMID:Radioimmunology. Imaging and therapy. 199 Dec 86

Renal and adrenal anatomy, both normal and abnormal, are well depicted by MRI. Although MRI is not a sensitive modality for detection of renal cell carcinoma, it has clinical utility for evaluation of vascular involvement or direct extension of neoplasm into adjacent organs when CT findings are equivocal. Use of signal characteristics has not been useful in differentiating simple from complex cystic renal masses or among the various causes of medical renal disease and renal transplant failure. Similarly, signal characteristics are not sufficiently reliable for differentiating benign from malignant adrenal masses. MRI is useful, however, for detection and localization of pheochromocytomas. MRI plays a major role in imaging of children with neuroblastoma and Wilms' tumor and may obviate other, often more invasive, examinations in these cases.
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PMID:Magnetic resonance imaging of the kidneys and adrenals. 216 Dec 46

Adrenal hemorrhages in newborns are usually diagnosed by sonography. Magnetic resonance imaging is indicated when morphological change, clinical appearance and follow-up do not allow differentiation of adrenal hemorrhage and neuroblastoma. Using artefact-suppressing sequences, the adrenal gland can be examined with modern MRI systems. The adrenal gland hemorrhage is characterized by a typical signal behaviour. If a haematoma persists over a longer period, a circular methemoglobin zone can be observed. An additional contrast application (Gadolinium-DTPA) can aid in demonstrating vascular tumors.
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PMID:[Nuclear magnetic resonance tomography in the differential diagnosis of adrenal gland hemorrhage and neuroblastoma in a newborn infant]. 219 72

Neuroblastoma is one of the most frequent tumors in childhood. Suprarenal area is its main abdominal location, appearing in lesser proportion in paravertebral ganglionar chains. Its prediction depends principally on the age of the patient and the pathological stage. US are the best method for its diagnosis. Its most frequent appearance is as an hyperechogenic heterogeneous mass with calcifications inside. In evaluation tumoral extension, other complementary methods such as CT and MRI should be used.
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PMID:[Ultrasonic diagnosis of neuroblastoma]. 219 42

Mediastinal anatomy is well depicted by MRI. This article discusses the role of thoracic MRI in evaluating mediastinal, parenchymal, and pleural abnormalities in children. It is particularly useful in the evaluation of vascular anomalies and assessment of extension of neuroblastoma and can obviate other, more invasive, studies.
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PMID:Chest applications of magnetic resonance imaging in children. 227 Dec 9

MRI was performed on 25 infants, children and adolescents with thoracic and abdominal tumours. The specific contribution of MRI to diagnosis, treatment planning and therapy monitoring is demonstrated. In some cases the T1 and T2 relaxation times were determined; this may clarify the different signal intensities of tumour and neighbouring organs and contribute to differentiation between Wilm's tumour and neuroblastoma.
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PMID:[MR tomography of thoracic and abdominal tumors in childhood and adolescence]. 283 84

From March 1985 to February 1987, 41 patients (pts) presenting with a neuroblastoma underwent 52 MRI to detect bone marrow metastases. Mean age was 4 years (R: 6 m, 13 y). Acquisitions were done with a 1.5 t unit. Images were obtained in coronal (legs and pelvis) and sagittal (dorso-lumbar spine) sections. Nine out of 52 examinations were excluded because of artifacts or technical failure. In 13 cases, MRI was performed for initial staging, in 30 during follow-up. Out of 24 anatomically proven medullary involvement (18 pts), MRI showed focal abnormal signals in 23 (17 pts): foci of hypersignal in T2 weighted images, compared to the normal value of bone marrow and fat tissue, were more often detected in lower limbs than dorso-lumbar vertebral body or iliac bone. In our series, the sensitivity of MRI to detect BM metastases is 84% and the specificity is 88%. In comparison to the medullograms and bone marrow biopsy, MRI explores distinct sites, especially lower limbs which are often involved.
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PMID:[Magnetic resonance imaging for bone marrow metastases of neuroblastoma]. 335 59

Forty-one patients (pts) presenting with a neuroblastoma underwent 52 MRI to detect bone marrow metastases. Mean age was 4 years. Acquisitions were done with a 1.5 tesla unit. T1 and T2 weighted images were obtained in coronal (legs and pelvis) and sagittal (dorso-lumbar spine) sections. In 13 cases MRI was performed for initial staging, in 30 during the follow-up. 43/52 examinations were evaluable. Out of 24 anatomically proven medullary involvement (19 pts), MRI showed focal abnormal signals in 23 (18 pts): foci hypersignal in T2 weighted images and hyposignal in T1 weighted images compared to the normal bone marrow (BM) and fat tissue. The lesions were more often detected in lower limbs than dorso-lumbar vertebral body or iliac bone. Nineteen examinations were performed in 15 pts with cytologically and histologically normal BM. MRI raised suspicion of BM metastases in 5 pts (7 MRI). Out of those 5 pts, 1 (2 MRI) had BM relapse 9 months later; 1 (2 MRI) had intra cranial relapse 6 months later; 1 (1 MRI) is disease free 1 1/2 year later; the follow-up is too short for 2 remaining pts (2 MRI). MRI's specificity was 88.9% and sensitivity 84.4%.
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PMID:Bone marrow metastases in children's neuroblastoma studied by magnetic resonance imaging. 340 18


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