Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027819 (
neuroblastoma
)
27,800
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Cell division cycle associated 2(
CDCA2
) is overexpressed in
neuroblastoma
and oral squamous cell carcinoma, and its overexpression positively correlates to tumor progression. However, the biological and clinical significance of
CDCA2
in lung adenocarcinoma(LAC) has never been investigated. We determined the expression profile and clinical significance of
CDCA2
using The Cancer Genome Atlas(TCGA) and tissue microarray(TMA). Furthermore, we explored the biological function of
CDCA2
both in vitro and in vivo. A great upregulation of
CDCA2
was observed in LAC tissues compared with adjacent normal tissues. Importantly, Cox regression analysis indicated that high level of
CDCA2
was an independent risk factor for overall survival(OS) in LAC patients (TCGA: HR = 1.720, p = 0.004; TMA: HR = 1.971, p = 0.023). Inhibition of
CDCA2
suppressed the proliferation of LAC cells via G1 phase arrest by downregulating cyclin E1(CCNE1), while overexpression of
CDCA2
promoted LAC cells proliferation by upregulating CCNE1. Moreover, the oncogenic activity of
CDCA2
was also confirmed in vivo. In conclusion,
CDCA2
promotes proliferation of LAC cells and predicts poor prognosis in LAC patients.
CDCA2
might play a significant role in LAC progression.
...
PMID:CDCA2 promotes lung adenocarcinoma cell proliferation and predicts poor survival in lung adenocarcinoma patients. 2842 19
