Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027819 (
neuroblastoma
)
27,800
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Despite the introduction of 13-cis-retinoic acid (13-cis-RA) into the current chemotherapy, more than half of high-risk
neuroblastoma
patients have experienced tumor relapses driven by chemoresistant cancer stem cells (CSCs) that can be isolated by their ability to grow as spheres. Although aldehyde dehydrogenase (ALDH) has been used to characterize CSCs in certain cancers, ALDH remains elusive in
neuroblastoma
. In the present study, we determined ALDH activity and expression of its 19 isoforms in spheres and parental cells of
neuroblastoma
. ALDH activity and several ALDH isoforms were consistently induced in spheres of different
neuroblastoma
cells. While ALDH1A2, ALDH1L1 and
ALDH3B2
expression was consistently induced in spheres and associated with the sphere and colony formation, only ALDH1A2 expression was significantly correlated with the poor prognosis of
neuroblastoma
patients. ALDH1A2 expression was further associated with the growth and undifferentiation of
neuroblastoma
xenografts and the resistance of
neuroblastoma
cells to 13-cis-RA. These results suggest that ALDH1A2 is involved in the regulation of CSC properties in
neuroblastoma
.
...
PMID:Involvement of aldehyde dehydrogenase 1A2 in the regulation of cancer stem cell properties in neuroblastoma. 2552 80
