Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027819 (
neuroblastoma
)
27,800
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Neuroblastoma
is a childhood tumour of the sympathetic nervous system that demonstrates striking clinical heterogeneity. In order to determine which genes are abnormally expressed in
neuroblastoma
, we screened regions of amplification from the short arm of chromosome 2 in the
neuroblastoma
cell line IMR-32 and found that the homeobox gene,
myeloid ecotropic integration site 1
(
MEIS1
), is highly amplified.
MEIS1
normally maps to chromosome band 2p14. High expression of
MEIS1
without amplification was also found in other
neuroblastoma
cell lines, with and without MYCN amplification, and in medulloblastoma and crythroleukaemia cell lines.
MEIS1
is highly expressed in cerebellum and ubiquitously expressed in normal immunohaematopoietic tissues and is thought to be important in cell proliferation and differentiation. While several lines of evidence point towards a role for homeobox genes in the development of other malignancies, this is the first report showing the amplification of a homeobox gene in
neuroblastoma
.
...
PMID:The homeobox gene MEIS1 is amplified in IMR-32 and highly expressed in other neuroblastoma cell lines. 1109 11
