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Query: UMLS:C0027819 (neuroblastoma)
 27,800 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three patients are reported in whom the diagnosis of neuroblastoma was made following electron microscopy of a bone marrow aspirate. The ultrastructure of neuroblastoma cells is distinctive, and they can be distinguished by electron microscopy from cells of the other tumors with which neuroblastoma is often confused by light microscopy. The rapidity with which the diagnosis can be obtained through use of this procedure argues for its adoption in any patient in whom the diagnosis is suspected and who has tumor cells in bone marrow. Early initiation of appropriate therapy is made possible, and elaborate diagnostic procedures may be avoided.
Pediatrics 1975 Dec
PMID:Diagnosis of neuroblastoma by electron microscopy of bone marrow aspirates. 119 55

A full-term black boy had a 2- to 3-cm, round, bluish mass on his right lower eye-lid at birth, later diagnosed as rhabdomyosarcoma. It was cystic in nature and extended into the nasal cavity. The tumor was initially classified as neuroblastoma. The child died eitht months later and necropsy report confirmed an original ophthalmologic pathology diagnosis of embryonal rhabdomyosarcoma.
Am J Ophthalmol 1975 Dec
PMID:Rhabdomyosarcoma of the orbit in the newborn. 120 95

Thirty-two children with solid tumors (lymphangioma, fibrosarcoma, hepatocarcinoma, osteogenic sarcoma, rhabdomyosarcoma, lymphosarcoma, mesenchymoma, hepatoma, Ewing's sarcoma, reticulum cell sarcoma, neuroblastoma, Hodgkin's disease, and brain tumors) were studied for alterations in coagulation by means of platelet counts, platelet aggregation, thrombelastogram, procoagulant and antigenic factor VIII, fibrin split products, and antithrombin III level. Results indicated hypercoagulability as shown by abnormally short thrombelastograms and elevated factor VIII levels and platelet counts in approximately one-half of the group. With the exception of increased fibrin split products in a third of the patients, little laboratory or clinical evidence for disseminated intravascular coagulation was seen. Hypercoagulability, as noted in adult carcinoma patients, can also occur in childhood sarcoma patients.
J Pediatr Surg 1975 Dec
PMID:Hypercoagulability in childhood cancer. 120 73

Several neuroblastoma clones and the same clones adapted to proliferation in a medium containing 15 mug/ml of 8-azaguanine and 6-thioguanine are characterized with respect to their morphology, acetylcholinesterase activity, catecholamine content and chromosomal pattern. Interclonal as well as intraclonal heterogeneity was found for the cell parameters studied. A reduction in the number of catecholamine-containing cells was observed in the azaguanine and thioguanine resistant adrenergic (M1, N115) cells compared with their parental lines. An increase of choline acetyltransferase activity was found in the M5 cholinergic clone, and a decrease of the same activity in the S21 cholinergic line selected in the medium with the purine analogues. Furthermore, a striking change in the distribution of chromosomes and chromosomal markers appeared in the resistant cells of all clones.
Neurobiology 1975 Dec
PMID:Morphological, histochemical and chromosomal patterns of neuroblastoma parental and purine resistant lines. 120 69

A thin-layer chromatographic technique for separation and identification of urinary phenolic acids is described. The method is simple enough to be used in the clinical laboratory and from it, an easy biochemical diagnosis of secreting neuroblastoma. The technique is also of interest for research in catabolism of catecholamines. Results obtained in 125 patients, including 8 patients with neuroblastoma are reported.
Eur J Pediatr 1975 Dec 09
PMID:Thin-layer chromatography for diagnosis of secreting neuroblastoma. 121 38

Four patients with skeletal metastases from retinoblastomas are presented. Radiologically, the metastases showed periosteal new bone formation and permeative-type bone destruction, particularly involving the long bones of the extremities, and they tended to be bilateral. The metastases resembled those of neuroblastoma and, to a lesser extent, medulloblastoma. The relationship between these three tumors is discussed.
J Can Assoc Radiol 1975 Dec
PMID:Skeletal metastases from retinoblastoma. 122 22

Serums from six patients with progressive idiopathic acute or chronic polyneuropathy possessed a cytolytic activity against transformed mouse cholinergic or noncholinergic neuroblasts but not against transformed rat astrocytes. This activity was not qualitatively nor quantitatively present in serums from normal controls or from patients with a variety of other motor system disorders and other neurologic disorders. Fluorescein conjugated goat antihuman IgG and IgM monospecific immunoglubulins were used to characterize further the cytotoxic activity from patient serums and these studies suggested the presence of immunoglobulin G (IgG) and immunoglobulin M (IgM) directed against a cell surface neuroblastoma antigen. Cold reactive immunoglobulins of the IgG and IgM type were present in the serums of all six patients. A bioassay is described that may be helpful in evaluating other patients with progressive idiopathic polyneuropathies.
Neurology 1975 Dec
PMID:Idiopathic polyneuropathy associated with cytotoxic anti-neuroblastoma serum. IgG and IgM immunoglobulin studies. 123 54

A child with opsoclonus associated with occult neuroblastoma is presented, in whom regression of the eye movement disorder through phases of flutter and dysmetria was observed. It is speculated that these ocular motor abnormalities represent a continuum of cerebellar dysfunction. A peculiar dysmetric head movemment not related to saccadic palsy is documented.
Br J Ophthalmol 1975 Dec
PMID:Opsoclonus. Pattern of regression in a child with neuroblastoma. 124 Jul 67

During inflammatory states, hepatocytes are induced to synthesize and secrete a group of proteins called acute-phase proteins. It has recently been shown that besides interleukin-6 (IL-6), related cytokines such as leukemia inhibitory factor, oncostation M and interleukin-11 are also mediators of the hepatic acute-phase response. All these mediators belong to the hematopoietic family of alpha-helical cytokines. Here we show that an additional member of this cytokine family, ciliary neurotrophic factor (CNTF), induces the hepatic acute-phase protein genes haptoglobin, alpha 1-antichymotrypsin, alpha 2-macroglobulin and beta-fibrinogen in human hepatoma cells (HepG2) and in primary rat hepatocytes with a time course and dose-response comparable with that of IL-6. Our next aim was to define the receptor components used by CNTF on hepatic cells. Using a cell-free binding assay we exclude that CNTF binds to the 80 kDa IL-6 receptor, a protein with significant homology to the CNTF receptor which has recently been cloned from neuroblastoma cells. In human hepatoma cells (Hep3B) which lack the leukemia inhibitory factor receptor, CNTF was not able to induce acute-phase protein synthesis, indicating that this receptor protein may be part of the functional CNTF receptor on hepatic cells.
FEBS Lett 1992 Dec 21
PMID:Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes. 128 89

We have recently presented a model of human adrenal medullary histogenesis that incorporates all neural crest-derived lineages (chromaffin, sustentacular, and ganglionic) known to compose this tissue. To determine if neuroblastomas correspond to the arrested maturation of embryonal adrenal medullary cells, we evaluated the expression of adrenal medullary developmental markers in 81 neuroblastoma tumors. We found that patterns of chromaffin-related gene expression in these tumors correlated exactly with the patterns observed during maturation of adrenal medullary cells (P2 < 10(-5). In a multivariate Cox proportional hazards analysis of developmental marker expression and other well-recognized prognostic variables, evidence of maturation along a fetal ganglionic lineage, as monitored by HNK-1 immunoreactivity (relative risk of 6.42, P2 = 0.0001), and age at diagnosis (relative risk of 5.05, P2 = 0.0042) were independent and significant prognostic indicators of patient survival. These studies demonstrate that neuroblastomas correspond to embryonal adrenal medullary cells arrested at recognizable stages during development, and that evidence of maturation along a fetal ganglionic lineage appears to have major importance in predicting patient survival.
J Clin Invest 1992 Dec
PMID:Plasticity of neuroblastoma tumor cells to differentiate along a fetal adrenal ganglionic lineage predicts for improved patient survival. 128 33


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