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Query: UMLS:C0027819 (neuroblastoma)
 27,800 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It is already known that cells respond strongly to topography and chemistry of 2D surfaces. In this work we study cell-material interactions; in particular, we investigated the attachment and alignment of SH-SY5Y cells of neuronal origin on grooved-patterns made from Silicon (Si) and Gold (Au). The Au-Si groove-pattern stimulated 93% of SH-SY5Y cells to differentiate into neuroblast-like type (N-type) in 2 days and outgrown neurites exhibited strong anisotropy along the grooves with 90% of cells having one or two neurites. In comparison, random distribution of morphology type, neurite number, and alignment were observed on control flat surfaces (Si and Au). We further show that designed Au-Si groove-patterns can be used to form reversed groove patterns on polycarolactone surface via soft lithography approach. Sixty-nine percentage of SH-SY5Y cells aligned along the obtained reversed groove patterns of the same dimensional characteristics to Si-Au grooves. In particular, this work demonstrated that the Au-Si grooves pattern stimulates neurite polarity, elongation, and morphological differentiation of neuroblastoma cells without any exogenous supply of growth factors or stimulants in just 2 days, which can lead to selective procedure of obtaining homologous population of neuron-like cells for future nerve regeneration therapies.
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PMID:Groove-patterned surfaces induce morphological changes in cells of neuronal origin. 3113 88

We have determined the density of four pieces of single crystal silicon in terms of universally accepted standards of mass and length. These four objects will be used as a working density standard to which all future density work in the United States will be referred. Using these crystals as standards, NBS can calibrate other objects as density standards for associated laboratories. The work was accomplished with the assistance of an interferometer, developed especially for the task, which measures the diameter of commercially available steel balls. From measured diameters ball volumes are calculated. The volumetric information contained in the balls is transferred to the silicon crystals in a newly designed hydrostatic weighing experiment. We have made three independent density determinations on each of the four crystals, and the presently accepted values of the density of each crystal is the average of the three determinations. The random component of uncertainty (3 standard deviations) of these four averages is 0.7 ppm. The systematic error is estimated to be about 0.7 ppm.
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PMID:A Density Scale Based on Solid Objects. 3218 72


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