Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027819 (
neuroblastoma
)
27,800
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Neuroblastoma
is a childhood tumor that is derived from the sympathetic nervous system. In recent years, great progress has been made in our understanding of
neuroblastoma
. However, applying theories to improve disease outcomes remains challenging. In this study, we observed that
calcium homeostasis endoplasmic reticulum protein
(
CHERP
) was involved in the maintenance of
neuroblastoma
cell proliferation and tumorigenicity. Moreover, elevated
CHERP
expression was positively correlated with poor patient survival, whereas low
CHERP
expression was predictive of better outcomes. Additional functional studies showed that
CHERP
knockdown inhibited
neuroblastoma
cell proliferation
in vitro
and resulted in defective tumorigenicity
in vivo
. Moreover,
CHERP
depletion suppressed
neuroblastoma
cell proliferation by inducing endoplasmic reticulum stress and cell apoptosis. Considering the functional roles of
CHERP
in
neuroblastoma
development and maintenance,
CHERP
might function as a novel therapeutic target for
neuroblastoma
patients.
...
PMID:Down-regulation of CHERP inhibits neuroblastoma cell proliferation and induces apoptosis through ER stress induction. 2911 58
