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Query: UMLS:C0027819 (neuroblastoma)
 27,800 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two cases of olfactory neuroblastoma mixed with other neoplastic elements are reported. One tumor contained foci of adenocarcinoma and of ganglioneuroblastoma in addition to an undifferentiated small cell component consistent with neuroblastoma; the other tumor histologically resembled small cell undifferentiated carcinoma with foci of squamous differentiation, but was shown by electron microscopy to be neuroblastoma. The histogenesis and treatment of mixed tumors of this type are discussed.
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PMID:Mixed olfactory neuroblastoma and carcinoma. A report of two cases. 620 41

Primitive neuroectodermal tumors are morphologically similar malignant tumors arising in intracranial and peripheral sites of the nervous system, showing varying degrees of cellular differentiation with a tendency to disseminate along cerebrospinal fluid pathways. They occur primarily in children and young adults. Under the designation primitive neuroectodermal tumors are included medulloblastomas and tumors that may differentiate in other directions, such as medulloepithelioma, neuroblastoma, polar spongioblastoma, pineoblastoma, ependymoblastoma, retinoblastoma, and olfactory neuroblastoma. From a practical, histologic point of view, these tumors are often indistinguishable from one another and are best thought of as primitive neuroectodermal tumors with or without differentiating features.
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PMID:Primitive neuroectodermal tumors of the central nervous system. 630 40

The histopathology of neuroblastomas of the olfactory nerve, especially the difficult differential diagnosis is described by means of our own observations, and compared with other less differentiated malignant tumours of the inner nose. Ultrastructural results are presented, histogenesis and classification of olfactory neuroblastomas in neuroepithelioma, neurocytoma and neuroblastoma are discussed. The literature is reviewed, whereby clinical symptoms, therapy and prognosis of these tumours are described.
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PMID:[Neuroblastoma of the olfactory nerve]. 634 30

The natural history of a personal group of eight patients with olfactory neuroblastoma is reviewed with particular reference to surgical pathology as revealed by a study of the operative specimens in seven of these patients. This reveals that spread to the cranial surface of the overlying dura must be considered to be present in all patients irrespective of the radiologic findings. Craniofacial resection is therefore considered to be an essential part of any treatment regimen.
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PMID:Surgical pathology of olfactory neuroblastoma. 649 Mar 85

A patient with olfactory neuroblastoma had extensive involvement of the nasopharynx, sinuses and orbit, and cervical metastasis. After surgical biopsy and excision of metastatic disease, she was treated with chemotherapy: three cycles of high-dose cisplatin (100 mg/sq m) and infusion of fluorouracil (1 g/sq m/day for five days). Subsequent treatment included definitive radiation therapy followed by three additional cycles of chemotherapy. The patient is free of disease three years after initiating therapy. This case report demonstrates the potential efficacy of planned combined modality therapy, including early chemotherapy in the control of locally advanced, unresectable olfactory neuroblastoma.
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PMID:Olfactory neuroblastoma. Chemotherapy and radiotherapy for extensive disease. 654 69

We present the first case report of an olfactory neuroblastoma (esthesioneuroblastoma) diagnosed by cytologic examination. The patient was a 40-year-old male who had a 13-year history of "adenocarcinoma" of the nasal cavity until the correct diagnosis of olfactory neuroblastoma was made cytologically from pleural fluid shortly before his death. The cells had the typical features of rosette formation, scanty elongated cytoplasm, clustering of cells and nuclear compression resulting in an "onion-skin" appearance. Surgical specimens, several biopsies and fine needle aspiration of a metastatic deposit in a lymph node all showed, retrospectively, features of esthesioneuroblastoma. Electron microscopy showed membrane-bound dense-core secretory granules. Autopsy findings revealed multiple metastases but no tumor at the original site; that tumor had been treated with high-dose radiation therapy as well as systemic chemotherapy. Olfactory neuroblastoma is a rare tumor, but it is important to recognize because it has a better prognosis than the more commonly encountered malignancies of the nose.
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PMID:Cytologic diagnosis of olfactory neuroblastoma. Report of a case with multiple diagnostic parameters. 657 48

A case of olfactory neuroblastoma has been presented. The clinical signs and symptoms described in this case are not uncommon and often result in early misdiagnosis. The favorable prognosis for olfactory neuroblastoma dictates early diagnosis, using the clinical signs and symptoms along with adjunctive aids such as incisional biopsy, panoramic survey, and CT scanning. Surgical excision followed by radiation therapy in an early diagnosed case of olfactory neuroblastoma greatly increases the five-year survival rate.
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PMID:Olfactory neuroblastoma: report of case. 658 93

The mouse neuroblastoma cell (N-18 clone) was used as a model for an olfactory cell. The N-18 cell was found to be depolarized reversibly by various species of odorants. The minimum concentrations of odorants which induced depolarization (threshold concentration) varied greatly with the species of odorants. There was a good correlation between the order of the threshold concentrations for various odorants in the N-18 cell and that in the frog olfactory responses. Replacement of Na+ and Cl- with impermeable ions or reduction of calcium concentration from 1.8 mM to 0.1 mM had practically no effect on the magnitude of the depolarization response to odorants. The input membrane resistance was little changed during the depolarization induced by various odorants. No reversal potential was observed when the cell was depolarized by n-amyl acetate or vanillin. It is suggested that the depolarization of N-18 cell by odorants is induced by changes in the phase-boundary potential at the outer surface of the cell.
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PMID:Neuroblastoma cell as model for olfactory cell: mechanism of depolarization in response to various odorants. 660 64

The biologic behavior of olfactory neuroblastoma in 21 persons treated at the Mayo Clinic, Rochester, Minn, from 1960 to 1980 is reviewed. Follow-up data of five years or more are available for 19 cases. Findings showed the tendency of these tumors to spread submucosally and intracranially without obvious involvement of the anterior cranial fossa dura. The aggressive nature of this lesion has not been appreciated. Metastatic disease occurred in 62% and local recurrence in 57%. Long-term follow-up showed that recurrent or metastatic disease could occur up to ten years after initial diagnosis. The five-year survival rate was 58%. Only four patients who have been follow-up for more than five years were without local recurrence or metastasis. This review should prompt a change in the current attitudes toward treatment of this tumor.
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PMID:Olfactory neuroblastoma. Biologic and clinical behavior. 663 53

The case is described of an eight-year-old Nigerian boy who died from olfactory neuroblastoma which presented with nasal obstruction and epistaxis. Autopsy showed intracranial extension of the tumour into the frontal lobe, and histology revealed undifferentiated neuroblasts, forming rosettes in some areas and producing tangled neurofibrils in others. The histogenesis of the tumour and its diagnosis are briefly discussed.
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PMID:Olfactory neuroblastoma. A case report in an African child. 683 51


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