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Query: UMLS:C0027819 (neuroblastoma)
 27,800 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A close collaboration between E.N.T. surgeons and pathologists permitted us to obtain 6 cases of olfactory esthesioneuroma in which fresh tumor tissue was available. Histochemical and biochemical studies were made in comparison with neuroblastoma. Different reactions and assays performed revealed a similarity with sympathetic tumors. Moreover, the presence of catecholamines in esthesioneuroma provides a great help in diagnostic as does electron microscope examination.
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PMID:A new histochemical approach to olfactory esthesioneuroma. A nasal tumor of neural crest origin. 19 6

A case of olfactory neuroblastoma occurring in a 3-year-old girl is reported. The rarity of the lesion in early childhood is stressed and discussed with the clinico-pathological characteristics of the tumour, which are apparently more aggressive the younger the patient. Olfactory neuroblastoma should be considered as a possible diagnosis regardless of the age of the patient.
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PMID:Infantile olfactory neuroblastoma. A clinicopathological study with review of the literature. 38 19

Olfactory neuroblastoma is a malignant neoplasm with a varied biological behavior. Its clinical course is unpredictable and there is no correlation between its microscopic features and biological behavior. The present study deals with light and ultrastructural characteristics of two cases of olfactory neuroblastoma of the nasal cavity. In one patient, the definitive diagnosis was established on the basis of ultrastructural features of the lesion. The most consistent fine structural findings were the presence of intracytoplasmic densecored neurosecretory granules, "true" and "pseudo-" rosettes, and the neuritic processes emanating from the tumor cells. On the basis of their biochemical, histochemical, and ultrastructural characteristics, olfactory neuroblastomas are similar to neuroblastomas arising from the adrenals or sympathetic nervous system. These findings, therefore, support the hypothesis that olfactory neuroblastomas are most likely of neural crest origin and thus belong to a group of neoplasms collectively known as "apudomas" or neurocristomas. The literature review strongly favors combined surgery and postradiation as the most effective treatment of olfactory neuroblastoma.
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PMID:Olfactory neuroblastoma (esthesioneuroblastoma): a light and ultrastructural study of two cases. 38 58

Two cases of olfactory neuroblastoma have been described. A review of the aetiology, histopathology and radiological features has been undertaken. A regime of current treatment policy has been described.
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PMID:Olfactory neuroblastoma: long-term survival. 42 6

Five cases of histologically confirmed olfactory neuroblastoma (esthesioneuroblastomas) have been studied by computed tomography (CT). Both the clinical symptoms (in particular, unilateral nasal obstruction and recurring epistaxis) and radiological findings (opacity of the paranasal sinuses) are nonspecific. Computed tomography shows a contrast enhancing mass-lesion and is more useful than conventional tomography in estimating its extension and the associated bone destruction, secondary reaction of sinusitis, and tumoral calcification. In the two cases in which the tumor was associated with exophthalmos, CT demonstrated that the muscular cone acts as a barrier preventing tumoral invasion. In cases wtih intracranial involvement, it appears that the attenuation values can be useful for differentiating between invasion by contiguity (two cases) versus metastasis (one case). Computed tomography is valuable in the follow-up and during and after radiotherapy of the tumor.
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PMID:Computed tomography in olfactory neuroblastoma: one case of esthesioneuroepithelioma and four cases of esthesioneuroblastoma. 70 20

The author reports four cases of Ewing's sarcoma primarily located in the maxilla and emphasizes the rarity of such a primary location and the fact that this series contained cases observed at the Department of Otolaryngology of Padua University during the last three years which, though small, is the largest so far reported. In addition to a review of the world literature on the subject, the problems related to the differential diagnosis, in particular from reticulum cell sarcoma of bone, neuroblastoma and olfactory neuroblastoma are discussed. The cases reported are accurately described and histologically documented. Treatment of Ewing's sarcoma is also discussed and, according to the author, the elective therapeutic procedure should consider local irradiation and intermittent but prolonged systemic chemotherapy, leaving mutilating surgery only for recurrent tumours.
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PMID:Primary Ewing's sarcoma of the maxilla: a clinicopathological study of four cases. 71 27

Olfactory neuroblastoma is an uncommon malignant tumor originating in the olfactory epithelium in the roof of the nose. It usually produces nasal obstruction and secondary sinus disease and is often mistaken by the physician for a nasal polyp. Olfactory neuroblastoma has been observed to cause death by distant metastasis or by invasion through the cribriform plate and secondary meningitis in most instances, and is generally associated with a low cure rate. During the past eight years, we have treated three patients with olfactory neuroblastoma by a combination of extensive local surgery using the lateral rhinotomy approach with ethmoidectomy and medial partial maxillectomy, combined with either preoperative or postoperative irradiation therapy. From a review of the literature we have tried to draw meaningful conclusions regarding treatment.
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PMID:Olfactory neuroblastoma. Management and prognosis. 80 2

A modification of a flow olfactometer with a new application appartus, with which "quasi-free" nasal respiration allows the elimination of adaptation without a special testing room, subsequent results using this device to examine olfactory thresholds before and after septum operations, as well as reference to threshold increases in 57 post-operative cases of cheilognathopalatoschisis are reported. An esthesio-neuroblastoma as well as the deformity syndrome with cheilognathopalatoschisis and encephalodystrophy are used as examples for combined olfactory transmission and perception disorders. Studies of 55 smokers with primary neurosensory disorders demonstrated a threefold increase in the olfactory threshold and an up to 50% decrease "fatique-time". A mean acetone deviation factor of 1.93 was seen in 100 students from 20-27 years of age before and after eating. Correspondingly, after a substantial breakfast and lunch, the olfactory threshold attained its maximum daily value within 90 minutes, much more pronounced than after intake of 80 grams of glucose solution. In contrast to the literature, the olfactory threshold was seen to continuously increase, dependent on age. Studies of the perceptive and recognition threshold on 100 normal individuals and 28 patients with hyposmia exhibited with 3 sigma, a significant difference. In patients with hyposmia, the absolute values for the two threshold types vary greatly, however not their deviation factors. More importance should be attached to the sense of smell as the so-called lesser senses give us the greatest pleasures.
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PMID:Results of clinical olfactometric studies. 97 91

A case of an olfactory neuroblastoma of a 5 years old child is reported. The tumour propagated into the intracranial space and produced cerebellar symptoms. Features of the neuroblastic cells, found in the cerebrospinal fluid and their alterations as an effect of the intrathecal therapy with Mathotrexat are analysed. Authors emphasize the differences of alterations of leukaemic and neuroblastic cells called into being by the Methotrexat therapy.
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PMID:[Cytological changes in the csf caused by inthathecal administration of methotrexate. II. Studies on a case of neuroblastoma with cerebellar symptoms in a child]. 103 15

A case of olfactory neuroblastoma, type 1 (olfactory neurocytoma), in a 44-year-old man is described. The tumour grew extensively in the right nasal cavity with involvement of the maxillary sinus and ethmoidal region, but was radically removed at operation. The prognosis and treatment are discussed in the light of earlier literature.
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PMID:Olfactory neuroblastoma. 120 18


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