Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Drug
Enzyme
Compound
Query: UMLS:C0027819 (
neuroblastoma
)
27,800
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Tumours of the Ewing's sarcoma (ES) family and
neuroblastoma
(
NBL
) were examined by reverse transcriptase-PCR for expression of mRNA for endothelin (ET) receptors ET-A and ET-B, and the ligands ET-1, ET-2 and
ET-3
. The effect of ET-1,
ET-3
, an ET-1-neutralizing antibody and ET-A receptor antagonist BQ-123 on cell proliferation was examined using an ELISA. Loss of ET-B receptor mRNA occurred in 57% of ES and 42% of
NBL
tumours. This appeared to be associated with the presence of metastatic disease and disease progression. ET-A receptor mRNA was expressed in all ES and 85% of
NBL
tumours, and in all ES and
NBL
cell lines examined. All ET ligands were detected in
NBL
cell lines, but only ET-1 and ET-2 were expressed in ES cell lines. Treatment of ES and
NBL
cells with ET-1 increased proliferation, but
ET-3
had no effect. Incubation of ES and
NBL
cells with an ET-1-neutralizing antibody or BQ-123 decreased proliferation. The
ET-3
ligand and ET-B receptor may be associated with migration and metastasis of ES and
NBL
, whereas ET-1 (acting through the ET-A receptor) may regulate their proliferation.
...
PMID:Endothelins may modulate invasion and proliferation of Ewing's sarcoma and neuroblastoma. 1219 14
Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and
ET-3
) were added to HN33 (mouse hippocampal neuron chi
neuroblastoma
) cells. Among the three types of ET, only ET-1 increased the intracellular calcium levels in a PLC dependent manner with the induction of ERK 1/2 activation. As the result of ET-1 exposure, the survival rate of HN33 cells and the PKCalpha translocation into the plasma membrane were increased. We suggest that ET-1 participated in the neuroprotective effect involving the calcium-PKCalpha-ERK1/2 pathway.
...
PMID:Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca(2+)-PKCalpha-ERK pathway. 1830 2
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