Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027819 (
neuroblastoma
)
27,800
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Scutellariae radix is a Chinese herbal medicine that has been used to treat disease conditions accompanying inflammation and oxidative stress. In the present study, we examined the effect of Scutellariae radix extracts during acute ethanol exposure in N(2)a
neuroblastoma
. The Scutellariae radix extracts effectively inhibited ethanol-induced apoptosis and caspase-3/-7 activation. Ethanol induced the expression of
caspase-11
that has been known as a dual regulator of pathological apoptosis and inflammatory response. The ethanol-induced
caspase-11
expression was suppressed by pretreatment of the Scutellariae radix extracts. Furthermore, the activation of caspase-3/-7 and apoptosis were significantly inhibited in
caspase-11
-/- mouse embryonic fibroblasts following ethanol treatment. These results suggest that
caspase-11
has a regulatory role in ethanol-induced apoptosis, and the suppression of
caspase-11
may be a mechanism by which Scutellariae radix exerts its cytoprotective effect.
...
PMID:Scutellariae radix extracts suppress ethanol-induced caspase-11 expression and cell death in N(2)a cells. 1629 Feb 52
