Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027819 (
neuroblastoma
)
27,800
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Cinnamomin is a type II ribosome-inactivating protein (RIP) and its A-chain (
CTA
) is a RNA N-glycosidase. It is observed that modification of tyrosine residues by N-acetylimidazole (N-AI) causes almost complete loss of
CTA
activity. Adenine partially protects tyrosine residues from modification by N-AI. It is proposed that tyrosine residues are involved in the active site of
CTA
and they are crucial in recognition and binding of ribosomal RNA. Tryptophan residues of
CTA
are also studied by
NBS
modification.
...
PMID:The role of tyrosine residues in the RNA N-glycosidase activity of cinnamomin A-chain. 1456 Nov 40
