Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027819 (neuroblastoma)
 27,800 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Adrenal neuroblastomas, although quite common in children, are extremely rare in adulthood. Here, we are reporting the case of a 47-year-old male who presented with right flank pain and had a palpable mass in the same region. Contrast-enhanced computed tomography showed an irregular, poorly marginated heterogeneous mass lesion arising from the right suprarenal position. Urinary catecholamines were within normal limits. There was no evidence of metastatic disease. The mass was resected en-block along with the right kidney. Histopathologic examination revealed the diagnosis of a neuroblastoma. Adjuvant chemotherapy was instituted, but the pain recurred after 9 months. Despite subsequent chemotherapy, the mass continued to grow over the next 6 months with further infiltration into the liver and surrounding muscles. The patient has currently been started on external palliative radiation. We have also reviewed the literature to present a discussion on presentation, diagnosis, and management of this rare tumor.
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PMID:Adrenal neuroblastoma in an adult. 2357 83

Paraganglioma of the urinary bladder is an uncommon clinical entity. Neuroblastoma of the urinary bladder is another rare tumor with only 7 reported cases, all in children. This report presents the case of a composite paraganglioma and neuroblastoma in a 45 year-old male who presented with dysuria and flank pain. On the computerized tomography scan, the bladder wall overlying the tumor was smooth and the mass had a large exophytic component. The initial diagnosis was paraganglioma on transurethral resection. Following partial cystectomy and bilateral pelvic lymph node dissection, pathology confirmed a composite tumor consisting of paraganglioma and neuroblastoma. To our knowledge, this is the first report of such a composite tumor involving the bladder.
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PMID:Composite Paraganglioma and Neuroblastoma of the Urinary Bladder: A Rare Histopathological Entity. 3026 28