Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027819 (neuroblastoma)
 27,800 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty-five cases of malignant tumors of the face in children under 16 years of age were reviewed. In each case the presenting complaint was related to a mass of the face, without a known primary malignancy. Rhabdomyosarcoma was the most common malignancy, followed by equal numbers of histiocystic malignancies and malignant lymphomas. Chloroma and neuroblastoma were less common. Plain films were obtained on every patient and were always felt to be an appropriate part of the work-up. The plain films suggested or made the diagnosis of malignancy in 16 of the patients. The most helpful additional study was tomography. CT was the modality of choice for tumors originating in or extending into the orbit, and for intracranial extension. Xeroradiography best demonstrated a superficial soft tissue tumor. In evaluating facial malignancies, the number and sequence of examinations must be individualized according to the presentation.
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PMID:Malignant facial tumors in children: radiologic evaluation. Stressing value of conventional and computerized tomography. 625 35

There is a wide range of malignant tumours with an embryonic origin that can affect children in their early childhood including Rhabdomyosarcoma, Osteosarcoma, Chloroma, Retinoblastoma and neuroblastoma. Different protocols have been developed over the past years to treat these tumours and different combinations of radiotherapy, surgery and chemotherapy were used. This improved the survival rate considerably. This treatment has a marked effect on growth of soft and hard tissues in the affected regions of the head and face, leading to facial and dental abnormalities that become evident with growth. The great effect of radiotherapy and chemotherapy on craniofacial skeletal growth should be considered in all cases undergoing treatment for tumours. The resulting dental and maxillofacial abnormalities should be expected in all cases and its management require involvement of different members of the medical team including maxillofacial surgeon, restorative dentist, orthodontist, psychologist, dietician, speech therapist, the patient and the parents in order to achieve maximum results. This paper presents four patients who underwent radiotherapy and chemotherapy for treatment of embryonic tumours and discusses the main side effects of the treatment.
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PMID:Dental and maxillofacial abnormalities following treatment of malignant tumours in children. 1516 92