Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027819 (
neuroblastoma
)
27,800
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In human tumors, p53 inactivation occurs frequently by mutation, and possibly also by nuclear exclusion of wt p53. First reported by
Uta
Moll in 1992, p53 "cytoplasmic sequestration" has been thoroughly studied to elucidate molecular mechanism of this process, using
neuroblastoma
cell lines as model. An American team at the Columbia University has just isolated the cytoplasmic protein Parc [Nikolaev, Cell] which specifically binds to p53 and anchors it, so that the "guardian of the genome" cannot play its role in the nucleus. AntiParc siRNA-manipulation relocates p53 into the nucleus, restitutes a function to p and chemo-radiosensitivity to malignant neuroblasts.
...
PMID:[A new view on p53 protein cytoplasmic sequestration]. 1286 54
