Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027819 (neuroblastoma)
 27,800 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ependymoblastoma developed in a 28-month-old girl whose epileptic mother took diphenylhydantoin and methylphenobarbitone throughout pregnancy. The child was also shown to be a genetic carrier for ornithine transcarbamylase deficiency, an x-linked inborn error of urea cycle metabolism. The possibility of transplacental carcinogenesis should be considered, as other juvenile embryonic tumors such as neuroblastoma, melanotic neuroectodermal tumor, and mesenchymoma have been reported in offspring after diphenylhydantoin use by the mother during pregnancy.
 ...
PMID:Ependymoblastoma associated with prenatal exposure to diphenylhydantoin and methylphenobarbitone. 397 71

Primitive Neuroectodermal tumours (PNET) are small-cell malignant embryonal tumors showing divergent differentiation of variable degree into neuronal, glial, or rarely mesenchymal tissues. PNET belongs to the Ewing family of tumors. Tumors that fall under the heading PNET include medulloblastoma (commonest), pineoblastoma, pendymoblastoma, retinoblastoma, neuroblastoma and esthesioneuroblastoma. Ependymoblastoma is a synonym for PNET.
 ...
PMID:Supratentorial PNET in a young child. 2121 74