Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027819 (neuroblastoma)
 27,800 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Immature teratoma occurs occasionally in the brain of children and contains a large amount of immature neuronal tissue. These primitive neuronal components are a good target for studying the morphology of primitive neuroectodermal tumors, including neuroblastoma, ependymoblastoma, medulloepithelioma and so on. Primitive neural tubes are immunohistochemically and ultrastructurally studied in two cases of primary immature teratoma of the child brains, compared to true rosettes in a case of neuroblastoma, primitive neural tube in the fetal rat brain (9 to 13 days of gestational age). The study also extends to the pathology of PNET. Ultrastructurally the primitive neural tube like structures in two teratomas were virtually identical those of developing fetal rat brains and true rosettes in a neuroblastoma. However, these tubular structures are different from each other in immunohistochemistry. These differences are considered to reflect the different developmental lineage of the tumor cells, that is, neuroblastoma produces only neuroblastic cells, and primitive neural tubes in teratoma both neuroblastic and glioblastic cells. Rejuvenation of neuroblastoma cells seems to render a VIM-positivity of the tumor cells.
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PMID:[Immunohistochemical and ultrastructural studies of intracranial immature teratoma--a comparative observation on neuroblastoma, PNET and ependymal tumor, with a special reference to rosette structures]. 816 54

Immature teratoma of the stomach in the neonate is extremely rare.1(,)2 This report outlines a case of giant immature teratoma of the stomach, which was detected by prenatal ultrasonography in the third trimester as an echogenic mass contiguous with the stomach bubble. It increased from 4.5 cm in diameter to 7 cm between 34 and 37 weeks gestation. The baby was delivered by elective caesarean section at 37 weeks gestation. Neonatal imaging highlighted a differential diagnosis of nephroblastoma, neuroblastoma, pancreatoblastoma and teratoma. The infant underwent surgical excision of the abdominal mass on the 10th day of life. Histology revealed grade III immature gastric teratoma arising from the posterior wall of stomach, outlining the unknown implications of such a designation in an extraovarian site. The infant made a good postoperative recovery and is currently well 9 months later, without adjuvant therapy, and with no evidence of recurrent disease.
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PMID:Prenatal findings and neonatal immature gastric teratoma. 2168 82