Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027819 (neuroblastoma)
 27,800 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We compared the results, by prenatal ultrasonography, effected on 2592 foetus at the 15th-25th-35th weeks of gestation with the ones, made by postnatal ultrasonography, effected the 5th day of life on 2539 infants born from pregnancies previously monitored. We considered the obstructive and not obstructive malformations. The prenatal ultrasonography put in evidence 19 cases of urological pathology, which is 0.75%. The postnatal research established the truth of 14 cases, which is 0.55%; 7 cases underwent a precocious surgical operation. Percentage of positive false is 0.2%. The postnatal ultrasonography made evident 30 cases which can be considered pathological: 25 uropathy obstructive cases and 5 uropathy not-obstructive cases; 3 of them underwent precocious surgical operation. The result is 44 pathological cases (1.74% of infants). We also considered an heterogeneous group of non-nephro-urological anomalies (0.47%), a casual medical report of this research; in particular, 10 cases of surrenal hematoma and 1 case of neuroblastoma. The Authors remark that it's useful to complete the prenatal ultrasonographic research with another postnatal ultrasonographic research, particularly in the nephro-urological pathology; and they hope this system can be much more diffuse.
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PMID:[Screening of urologic pathology in newborns with prenatal and postnatal echography]. 848 21

External beam irradiation (EBRT) has been shown to improve response rates and event-free survival in children with neuroblastoma and regional lymph node metastases. Irradiation during surgical exposure (intra-operative radiotherapy, IORT) with displacement of adjacent radiosensitive organs out of the treatment field allows for more precise delineation of the target volume and significantly reduces the amount of normal tissue exposed to irradiation. We have incorporated IORT into the treatment regimen of 24 children with neuroblastoma between the years of 1983-1991. IORT was directed to any residual tumor or the tumor bed; the median dose of radiation was 1,000 cGY, equivalent to 3,000 cGY of conventional EBRT. There were 11 males and 13 females. Two patients had stage II, 12 patients had stage III, and 10 patients had stage IV disease. Ten children received IORT for suspected recurrent or persistent neuroblastoma. Twelve patients were disease-free survivors following IORT with a median follow-up of 54 months. For those patients with stage III disease, seven children were disease-free survivors, while only three of 10 patients with stage IV disease survived (median follow-up 30 months). Disease-free Survival (DFS) correlated with the achievement of local tumor control in children with both stage III and IV neuroblastoma. There was limited morbidity and no episodes of obstructive uropathy were encountered. We conclude that IORT appears to be well tolerated and may have therapeutic benefit for a select group of patients with neuroblastoma. IORT merits future exploration by prospective study.
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PMID:Intra-operative radiation therapy in pediatric neuroblastoma. 914 87