Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.35 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 42492
Mol 33353
p53 26657
cytokine 11561
MRI 9703
CD8 9317
epidermal growth factor receptor 7167
lymphoid 7152
vascular endothelial growth factor 7031
vimentin 6565
CD4 6315
estrogen receptor 6216
AKT 6137
caspase-3 5993
collagen 5983
She 5926
Bcl-2 5804
osteosarcoma 5764
nodal 5572
tyrosine kinase 5430
mTOR 5265
HER2 5218
Ki-67 5176
p21 5074
interferon 5036
PI3K 4968
E-cadherin 4912
catenin 4658
EGFR 4582
tumor necrosis factor 4571
IFN 4537
cage 4471
TNM 4396
VEGF 4089
carcinoembryonic antigen 4017
TNF 3952
cytokeratin 3933
insulin 3921
cyclin D1 3822
CD34 3796
PTEN 3777
ERK 3745
histone 3710
MAPK 3696
ATP 3645
BRAF 3644
IL-2 3464
IL-6 3383
glycoprotein 3375
p16 3370
CD44 3348
PD-L1 3174
NMR 3128
colon carcinoma 3113
progesterone receptor 3102
matrix metalloproteinase 3095
PD-1 3090
IFN-gamma 3004
KRAS 2893
rhabdomyosarcoma 2885
FDG 2879
PEG 2852
ras 2845
mucin 2845
endoplasmic reticulum 2829
ACS 2804
interleukin-2 2771
alpha-fetoprotein 2755
epidermal growth factor 2721
CEA 2715
STAT3 2708
fibronectin 2705
HLA 2653
thymus 2638
chemokine 2562
desmin 2540
fused 2450
somatostatin 2442
MHC 2436
proteasome 2401
polypeptide 2389
ERK1 2388
MMP-9 2370
proliferating cell nuclear antigen 2358
c-myc 2340
BRCA1 2322
p38 2271
PARP 2135
ubiquitin 2128
IL-10 2114
albumin 2093
MEK 2087
androgen receptor 2079
MMP-2 2067
P-glycoprotein 2053
c-Myc 2038
p27 2028
phosphatase 2000
non-Hodgkin's lymphoma 1992
CD31 1944
erbB-2 1917
Pol 1890
MHC class I 1859
receptor tyrosine kinase 1852
UTR 1844
proto-oncogene 1841
glial fibrillary acidic protein 1838
neu 1830
beta-catenin 1816
GSH 1815
Fas 1814
smooth muscle actin 1813
keratin 1809
S100 1807
histone deacetylase 1805
PC-3 1805
prolactin 1799
prostate-specific antigen 1787
major histocompatibility complex 1785
lectin 1785
survivin 1777
synaptophysin 1746
lipopolysaccharide 1743
APC 1740
gut 1728
EGF 1718
bcl-2 1702
CD20 1700
IL-8 1628
alkaline phosphatase 1600
interferon-gamma 1599
cyclin 1597
lymphokine 1595
TNF-alpha 1592
MYC 1583
hemoglobin 1573
JNK 1571
ROS 1570
CD56 1566
cyclooxygenase-2 1554
interleukin-6 1550
IL-4 1521
neuron-specific enolase 1518
CSF 1512
urokinase-type plasminogen activator 1501
caspase-9 1498
CD133 1495
serum albumin 1486
hormone receptor 1485
MDM2 1461
neurofibromatosis 1451
mutant p53 1424
cytochrome c 1415
VEGFR2 1413
ACTH 1403
CD68 1402
TGF-beta 1397
membrane-bound 1396
caspase-8 1381
PC3 1362
more...
Disease
tumor 685946
cancer 272229
carcinoma 56550
metastases 46273
breast cancer 44093
tumor growth 41526
adenocarcinoma 27974
tumorigenesis 27041
melanoma 26509
tumor progression 24176
hepatocellular carcinoma 22326
carcinogenesis 21494
lung cancer 19028
squamous cell carcinoma 17191
colorectal cancer 17079
prostate cancer 15437
lymphoma 15101
glioma 13459
primary tumor 12798
leukemia 11691
sarcoma 11581
gastric cancer 10997
renal cell carcinoma 10002
ovarian cancer 9624
colon cancer 9605
glioblastoma 8956
non-small cell lung cancer 8392
pancreatic cancer 8165
adenoma 7440
MCF 7430
lung carcinoma 7156
osteosarcoma 6675
brain tumor 6566
neuroblastoma 5855
bladder cancer 5785
multiple myeloma 5740
aggressiveness 5117
cervical cancer 5062
Hodgkin's disease 4894
liver cancer 4880
solid tumor 4707
epithelial ovarian cancer 4503
tumor angiogenesis 4239
residual disease 4162
dysplasia 4105
glioblastoma multiforme 3968
fibrosarcoma 3968
B-cell lymphoma 3958
meningioma 3943
retinoblastoma 3856
Epstein 3770
carcinoid 3734
acute myeloid leukemia 3639
liver metastases 3637
liver cancer 3624
schwannoma 3595
mammary tumor 3167
WT1 3154
endometrial cancer 3150
cirrhosis 3028
lung metastases 2989
hypertension 2954
astrocytoma 2913
anemia 2844
diabetes 2837
teratoma 2829
rhabdomyosarcoma 2816
hemangioma 2814
Hepatocellular carcinoma 2786
esophageal cancer 2758
uterus 2738
pheochromocytoma 2609
esophageal cancer 2571
leiomyosarcoma 2544
SCID 2512
mesothelioma 2506
skin cancer 2493
non-Hodgkin's lymphoma 2486
rectal cancer 2472
aggression 2470
metastatic melanoma 2463
tumor initiation 2369
metastatic breast cancer 2351
thyroid cancer 2312
benign tumor 2305
head and neck cancer 2248
HIV 2246
Ewing's sarcoma 2223
medulloblastoma 2135
Melanoma 2074
acute lymphoblastic leukemia 2071
tumor vasculature 2061
obesity 2037
chondrosarcoma 2032
Hippel 1982
bone metastases 1980
lymphadenopathy 1974
small cell lung cancer 1947
hepatitis B 1900
angiosarcoma 1891
stromal tumors 1878
transitional cell carcinoma 1877
renal cancer 1873
basal cell carcinoma 1868
Kaposi's sarcoma 1843
chronic lymphocytic leukemia 1838
APC 1833
GSH 1817
carcinoma in situ 1809
leiomyoma 1808
liposarcoma 1802
virus infection 1776
herpes simplex 1775
infectious diseases 1773
cold 1758
gastrointestinal stromal tumor 1742
neoplastic transformation 1725
AIDS 1720
immunodeficiency 1683
ductal carcinoma 1668
chronic myeloid leukemia 1663
Glioblastoma 1651
hematologic malignancies 1589
mole 1578
chronic lymphocytic leukemia 1577
papilloma 1572
thrombocytopenia 1563
brain metastases 1551
malignant fibrous histiocytoma 1540
hypercalcemia 1522
lipoma 1497
paraganglioma 1468
multiple endocrine neoplasia 1459
plaque 1432
Leukemia 1432
rare disease 1432
pneumonia 1421
Burkitt's lymphoma 1406
uterine cervix 1403
ATM 1374
neurofibromatosis 1366
ductal carcinoma in situ 1347
dysphagia 1346
pituitary adenoma 1341
neuroendocrine tumor 1332
Osteosarcoma 1321
Osteosarcoma 1321
ischemia 1319
hydrocephalus 1316
stroke 1313
depression 1309
neurofibromatosis type 1 1303
germ cell tumor 1303
fibroma 1296
thymoma 1292
tuberous sclerosis 1276
seminoma 1274
ependymoma 1266
carcinosarcoma 1253
epithelial tumor 1250
more...
Symptom
pain 7664
abdominal pain 3288
headache 3033
anesthesia 2268
dyspnea 1948
vomiting 1887
diarrhea 1876
seizures 1863
weakness 1713
nausea 1570
fatigue 1551
anorexia 1301
cough 1271
cachexia 1153
starvation 1005
chest pain 964
back pain 910
discomfort 831
discomfort 822
exhaustion 794
collapse 726
splenomegaly 689
hemoptysis 655
nausea and vomiting 616
epigastric pain 603
ataxia 542
numbness 503
flank pain 479
erythema 477
bone pain 454
hoarseness 428
acidity 428
constipation 425
paresis 417
dizziness 408
respiratory distress 407
hepatomegaly 398
Ill 361
low back pain 360
shortness of breath 357
masculinization 342
vertigo 338
paresthesia 321
tinnitus 313
ENT 309
dysuria 306
abdominal discomfort 305
lethargy 274
HSA 265
syncope 249
exertional dyspnea 244
overweight 244
cancer pain 244
analgesia 239
hepatosplenomegaly 236
chills 225
paraparesis 222
acute abdomen 220
flushing 214
pelvic pain 207
colic 199
hypothermia 191
neck pain 189
functional recovery 172
polyuria 168
thinning 166
asthenia 165
spasm 160
sleepiness 158
dysarthria 157
hemiplegia 157
abdominal fullness 148
rhinorrhea 145
ophthalmoplegia 145
fever of unknown origin 144
arthralgia 144
stridor 143
facial pain 143
blurred vision 140
myalgia 134
shoulder pain 132
cerebellar ataxia 130
tremor 128
polydipsia 124
acute abdominal pain 124
urinary frequency 119
angina 118
regurgitation 113
myoclonus 113
agitation 104
nipple discharge 103
leg pain 103
pallor 103
nipple discharge 100
hip pain 98
wheezing 96
decreased appetite 92
right upper quadrant pain 91
night sweats 87
cyanosis 86
knee pain 83
dysesthesia 82
distraction 81
neuralgia 81
emaciation 78
otalgia 77
nasal discharge 72
anosmia 71
sore throat 70
consciousness disturbance 69
hyperoxia 68
productive cough 67
sciatica 67
leg edema 66
bloating 65
intestinal bleeding 65
skin damage 64
hypoproteinemia 63
Scratch 62
insomnia 62
Cushingoid 62
memory loss 61
persistent cough 61
Cushingoid 60
anal pain 58
clubbing 58
chronic cough 55
torticollis 55
acute pain 55
tenesmus 53
spasticity 52
tachypnea 52
hypercapnia 49
Wind 48
tingling 47
skin irritation 45
oliguria 44
nasal congestion 43
hypotonia 42
ataxic gait 42
tense 41
tonic-clonic seizure 41
menopausal symptoms 39
testicular pain 39
acute stress 38
snoring 38
photophobia 38
hot flashes 37
heartburn 37
apathy 36
chest tightness 36
orthopnea 34
arm pain 34
thigh pain 34
hot flushes 33
right lower quadrant pain 33
partial seizure 32
pleuritic chest pain 31
dystonia 31
rigors 30
more...
Drug
Dermatol 5209
IL-2 3520
IFN-gamma 2930
CSF 2569
Cardiovasc 2538
lysine 2313
ROS 1570
Adriamycin 1271
CTX 824
Taxol 788
Herceptin 706
Monit 703
ROC 655
Meth 639
MAP 613
CPT-11 586
ascorbate 582
Paraffin 545
ENT 523
vitamin E 522
ADR 514
CAM 510
Sorafenib 496
Bevacizumab 494
ADM 484
Imatinib 447
ABC 445
HCG 438
Gel 428
uPA 427
Docetaxel 421
G-CSF 398
ETS 395
GEO 377
NADH 368
Mutagen 351
Lipiodol 338
PTH 325
Cetuximab 319
PTC 319
Gefitinib 314
ALA 311
VCR 301
IFN-beta 298
Rituximab 281
Gleevec 273
Bortezomib 273
Glutathione 269
EE2 268
CTX 266
Leaf 260
Retinoic acid 256
CTX 255
Asn 253
caffeine 250
Photofrin 240
TAT 233
MRC 230
G418 226
Fluorescein 226
Portal 215
ICI 213
Indomethacin 213
Etoposide 207
p75 199
lactose 197
Irinotecan 197
BLM 194
CTC 188
NVP 187
DNase I 184
Albumin 177
Nephron 177
VCR 174
Erlotinib 173
Estrogens 171
Taxotere 167
CTC 163
Oxaliplatin 159
DM1 157
THF 155
TTC 143
Everolimus 141
Gelatin 138
Leucovorin 134
Arsenic trioxide 133
Ipilimumab 132
CCL 130
Gelfoam 130
Fluorescein 125
MTC 123
Zoledronic acid 122
Nephron 122
Vitamin E 122
Growth hormone 121
MDS 117
CDX 114
CDX 114
ACT 109
Lovastatin 107
EPA 106
nitroglycerin 106
Growth hormone 104
TAC 104
Activin 104
Photofrin II 101
Bifidobacterium 99
Ethanol 98
citric acid 97
Cremophor EL 97
Spectrum 96
Norplant 94
Fraction 93
PDL 93
ZnO 93
Lenalidomide 91
R1881 88
Nitric Oxide 88
RFP 88
Vitamin A 87
Vorinostat 87
L-tyrosine 86
Zoledronic acid 85
-deoxyadenosine 83
Spectrum 83
Pemetrexed 82
IL-11 82
Thyroglobulin 80
Histamine 80
CTA 78
Vinorelbine 78
TAK 78
Heme 76
Glycyrrhiza 75
Indocyanine green 75
Imiquimod 74
PCB 74
Glucagon 74
Alliance 73
Denosumab 72
Amifostine 72
Dasatinib 72
ETA 71
NH3 70
FAD 69
Biopolymers 69
Parkin 69
Parkin 69
Hypaque 68
Fulvestrant 67
CoCl2 65
niacin 65
Emodin 65
CoCl2 65
Panitumumab 64
EPI 64
TEL 64
NBT 64
PMEA 63
anti-CD33 63
more...
Enzyme
ERK 21111
mitogen-activated protein kinase 10060
luciferase 5485
focal adhesion kinase 5148
protein kinase 5111
caspase-3 4651
protein kinase C 2938
ACS 2816
MEK 2660
proteasome 2451
PARP 2358
P-glycoprotein 2070
reverse transcriptase 1994
peroxidase 1896
APC 1837
urokinase-type plasminogen activator 1689
prostate-specific antigen 1657
catalase 1648
alkaline phosphatase 1604
lactate dehydrogenase 1527
thymidine kinase 1358
superoxide dismutase 1339
CD10 1311
glutathione S-transferase 1277
ATPase 1259
phosphatidylinositol 3-kinase 1225
cdc2 1209
caspase-9 1204
collagenase 1187
trypsin 1177
topoisomerase 1131
caspase-8 1077
AMP-activated protein kinase 1077
topoisomerase 1054
ornithine decarboxylase 1045
RNA polymerase 947
granzyme B 875
phosphoinositide 3-kinase 852
calcineurin 836
DNA methyltransferase 808
RNase 793
AMPK 787
MMP 772
alanine aminotransferase 772
RNase 730
thymidylate synthase 715
thrombin 650
beta-galactosidase 646
GSK 643
gamma-glutamyl transpeptidase 628
DNA polymerase 617
AMPK 615
matrix metalloproteinase 2 614
lysozyme 608
glutathione peroxidase 600
aspartate aminotransferase 593
enolase 560
prostate-specific membrane antigen 533
cathepsin B 531
acid phosphatase 523
plasmin 510
tyrosinase 506
renin 504
neuraminidase 500
carbonic anhydrase 492
succinate dehydrogenase 481
adenylate cyclase 456
aldehyde dehydrogenase 448
MDR 439
hyaluronidase 435
IKK 433
matrix metalloproteinase 9 432
aldehyde dehydrogenase 426
endonuclease 422
aldehyde dehydrogenase 411
aldehyde dehydrogenase 409
aldehyde dehydrogenase 409
NQO1 408
hyaluronidase 395
transcriptase 392
phospholipase C 383
dihydrofolate reductase 382
arginase 382
CD13 370
phosphodiesterase 365
cathepsin D 364
MMP-3 362
NOS 354
cytosine deaminase 328
lipoxygenase 327
ribonucleotide reductase 320
demethylase 312
hexokinase 310
MAP 309
isocitrate dehydrogenase 308
protein phosphatase 2A 306
phospholipase A2 306
NO synthase 306
pyruvate kinase 304
ribonucleotide reductase 304
ricin 303
isocitrate dehydrogenase 302
creatine kinase 292
tissue plasminogen activator 276
thymidine phosphorylase 274
glyceraldehyde-3-phosphate dehydrogenase 273
firefly luciferase 272
caspase-1 272
DCF 268
PDK1 267
ALDH 257
ribonuclease 255
ribonuclease 253
dihydropyrimidine dehydrogenase 250
DNase 246
indoleamine 2,3-dioxygenase 244
NADPH oxidase 238
MIP 235
polo-like kinase 1 234
TAT 234
complex I 234
NADPH oxidase 227
glutathione reductase 223
lipase 216
TdT 216
dihydropyrimidine dehydrogenase 209
asparaginase 209
beta-glucuronidase 207
MDP 207
ACE 201
STK11 197
transglutaminase 196
glucose-6-phosphate dehydrogenase 193
histone acetyltransferase 188
xanthine oxidase 187
AST 187
chymotrypsin 186
tyrosine hydroxylase 183
CPT 180
furin 177
TACE 176
chloramphenicol acetyltransferase 176
glutaminase 174
thioredoxin reductase 174
SPC 173
tryptase 171
acetylcholinesterase 165
kallikrein 164
kinesin 162
elastase 161
glyceraldehyde-3-phosphate dehydrogenase 157
lysyl oxidase 156
CPT 155
CPT 155
thromboplastin 154
glucose oxidase 152
caspase-7 150
BMT 150
caspase-7 149
farnesyltransferase 146
more...
Compound
DNA 58974
Dec 45106
Clin 36023
oxygen 12939
water 7811
glucose 6694
MDA 6249
calcium 6170
acetate 6163
MTT 5702
tyrosine 5321
PEG 5040
sodium 4448
TNM 4393
TNF 3952
phosphate 3837
PEG 3654
ATP 3649
iron 3355
sulfate 3182
methionine 3167
arginine 3129
lysine 3028
serine 2987
iodine 2887
ACS 2817
ACS 2805
nitric oxide 2533
cysteine 2466
His 2284
hydrogen 2196
Adriamycin 2183
galactose 2163
5-FU 2148
anthracene 2127
DBA 2121
leucine 2077
MEK 2048
GSH 1979
GSH 1979
retinoic acid 1945
threonine 1886
zinc 1886
ethanol 1872
DDP 1840
nitrogen 1801
bromide 1725
urea 1675
cAMP 1621
ADR 1597
ACTH 1405
alanine 1379
copper 1379
Asp 1314
hyaluronic acid 1312
DTPA 1191
Phe 1168
glutamine 1150
boron 1135
AMP 1086
Pac 1085
SCC 1068
SDS 1047
salt 1037
Gly 1029
DBA 1016
DBA 1016
tryptophan 1011
NH2 1008
pyrene 1003
silver 982
CO2 968
Thyroid 965
TPA 946
TPA 941
Estrogen 935
barium 928
pyrimidine 923
pyrimidine 916
creatinine 916
formaldehyde 913
BCG 913
potassium 909
fluorine 891
glutamate 877
ADP 871
Estrogen 846
Vimentin 841
PMA 826
CTX 825
vitamin D 813
selenium 802
GTP 793
tryptophan 789
tryptophan 770
tryptophan 770
Cardiol 769
ADP 767
ADP 764
H2O2 760
Curcumin 759
Optimal 755
NAD 745
Paclitaxel 744
TSH 734
ASA 732
dUTP 725
proline 714
TEM 709
CAM 699
PGE2 654
Insulin 653
THP 640
BCNU 637
THP 632
acetic acid 627
VP-16 611
NAD 602
ammonium 597
MMC 589
cobalt 587
CPT-11 584
PAS 567
methanol 552
Methotrexate 542
nicotinamide 536
N-acetylcysteine 533
glutamic acid 532
Tamoxifen 532
uridine 528
Tamoxifen 522
MCA 519
ADP-ribose 516
manganese 514
PGE 514
TOF 511
Gemcitabine 502
Gemcitabine 502
glycerol 499
phosphorus 499
NADPH 498
NADPH 497
GM1 494
MCA 489
BCR 488
aldosterone 487
pyridine 473
1,2-dimethylhydrazine 468
acetone 464
DMSO 462
Histone 459
aspartic acid 457
aldehyde 451
acridine 448
CAT 448
PGA 440
MDR 439
CAT 432
A 71 432
CAT 432
more...