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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a series of 100 patients with intracardiac myxoma, the lesion was in the right atrium in 10 cases. The authors attempt to define the particular features of right atrial myxoma in terms of clinical aspects, outcome and pathology. The diagnostic difficulty raised by complex clinical pictures (including right ventricular failure, pseudopericardial forms and forms with a predominance of systemic problems) has now been resolved by imaging and, above all echocardiography. Consequences for the right side of the heart may involve the pulmonary artery with myxomatous emboli causing multiple fusiform aneurysms and pulmonary hypertension, or, more rarely, the tricuspid (with need for valve replacement), vena cava (Budd-Chiari syndrome) or atrial septum (right/left shunt). Alongside systemic problems due to interleukin 6, erythrocyte abnormalities are a new feature. Frequent etiological inclusion in a Carney complex explains recurrences and multi-cavity forms. The dominant pathological feature is tumor calcifications, no doubt as a result of the long presymptomatic phase of myxoma.
Ann Cardiol Angeiol (Paris) 1992 Apr
PMID:[Myxoma of the right atrium. Apropos of 10 surgically treated cases]. 164 33

An unusual case of metastatic disease of the right ventricle is described in a 74-year-old woman who had presented with a malignant fibrous histiocytoma of the right thigh previously treated with surgery and radiotherapy. Two years later she presented with signs and symptoms of tricuspid regurgitation and right ventricular outflow tract obstruction. The diagnosis of right ventricular tumor was made by echocardiographic and angiographic studies and confirmed on postmortem examination.
Clin Cardiol 1991 Feb
PMID:Metastatic cardiac malignant fibrous histiocytoma presenting as right ventricular outflow tract obstruction. 164 90

99mTc-PMT delayed hepatobiliary imaging was performed preoperatively in 62 patients with small hepatocellular carcinoma. All patients received operation and had pathological proof. All these tumors were smaller than 5 cm in size. Liver scan was done 5 min, 2 and 5 hr after administration of radiopharmaceutics. The sensitivity was 33.3% (2/6), 41.2% (7/17), 60.0% (9/15) and 54.2% (13/24) in tumors with sizes of less than or equal to 2 cm, 2-3 cm, 3-4 cm and 4-5 cm groups, respectively. The positive rates in the first two groups were lower than in the last two groups but much higher than those by conventional imaging. The total positive rate was 50.0%. The difference was not significant in comparison with the group of tumor size greater than 5 cm. The smallest mass detectable was only 1.2 cm in diameter. The uptake of radiopharmaceutic was not related to serum AFP level and hepatic cirrhosis (P greater than 0.05). These results show that 99mTc-PMT delayed hepatobiliary imaging may be useful in the diagnosis, particularly in the pathognomonic diagnosis, of small hepatocellular carcinoma.
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PMID:[Diagnostic value of 99mTc-PMT delayed hepatobiliary imaging in small hepatocellular carcinoma--an analysis of 62 cases]. 165 87

The aim of this paper is to report for the first time the association between bronchiolo-alveolar carcinoma and acute myocardial infarction (AMI). Two patients suffering from this association were studied. A 59 year old male, diabetic, alcoholic and smoker was admitted because a diaphragmatic AMI. An interventricular septal defect and papillary posterior muscle rupture were confirmed at autopsy. A 0.8 cm diameter friable mass was found in the right lung superior lobe. The second case was a 69 year old male, smoker, who presented with a diaphragmatic and right ventricular posterior wall AMI. A round 1 cm diameter tumor was observed at the right lung superior lobe. It had a caseous aspect lying over a fibrous scar. Both cases had severe right coronary artery narrowings with recent occlusive thrombi. The cardiac valves were free of non-bacterial thrombotic endocarditis. Therefore the possibility of coronary embolization was discarded. As lung carcinomas produce vasospastic and thrombogenic mucins, these substances could have been responsible for the acute coronary thrombosis.
Arch Inst Cardiol Mex
PMID:[Acute myocardial infarction and bronchoalveolar carcinoma. Association or coincidence?]. 165 6

The first step towards the diagnosis of cardiac neoplasia is made when the clinician considers the diagnosis. While the classically described signs and symptoms of left-atrial myxomas are noteworthy, the vast majority of patients present with symptomatology that is less specific--either of a constitutional nature, or related to right- or left-sided congestion. Likewise, the physical examination may rarely disclose classic auscultatory signs, but is more likely to confirm the presence of the right- or left-sided congestion inferred from history. Peripheral, embolic, or vasculitis lesions should raise suspicion of the diagnosis. Nevertheless, the majority of patients will be diagnosed by the unexpected detection of a tumor at the time of echocardiography. Transthoracic echocardiography remains the procedure of choice in screening for cardiac neoplasia. It has excellent sensitivity for intracavitary and endocardial lesions. Myocardial lesions are also well imaged. Pericardial lesions, with or without extension into contiguous structures, are poorly visualized and, here, magnetic resonance imaging is unquestionably the superior investigative approach. Further, a limited degree of tissue characterization is possible with the latter technology. Transesophageal echocardiography is ideally suited for the examination of suspected tumors involving the atria, interatrial septum, superior vena cava, atrioventricular valves and, to a lesser extent, the ventricles. These three imaging modalities clearly complement one another and the choice of application will depend upon factors including the patient's transthoracic echogenicity, the availability of magnetic resonance imaging or transesophageal echocardiography, cost, and the physical status of the patient.
Curr Probl Cardiol 1992 Feb
PMID:Cardiac tumors: diagnosis and management. 173 41

In this report we study the value of ambulatory transesophageal echocardiography (TEE) in the clinical setting after a 2-year experience at our department. Since December 1988 until February 1991, 470 TEE examinations were indicated in 430 patients. Excluded were 8 cases, two out of them due to a formal contraindication and six who did not tolerate the procedure. The clinical indications for the examination, in the 462 studies performed, were as follows: possible cardiac source of emboli in 165 (35%); native mitral valve disease in 91 (20%); prosthetic valve dysfunction in 54 (12%); diseases of the aorta in 44 (10%); suspected infective endocarditis in 41 (9%); study of left ventricular function in 26 (6%); congenital heart disease in 18 (4%); tumor or intracardiac mass in 11 (2%); miscellaneous in 12 (2%). Based on this experience, we can conclude that TEE is a clinically useful technique for: 1) the study of mitral regurgitation, either native or prosthetic; 2) the detection of vegetations and abscesses in infective endocarditis; 3) the evaluation of a possible cardiac source of emboli; 4) the examination of the aorta in cases of suspected dissection; 5) the completion of the anatomic study in some congenital heart diseases, particularly after a surgical correction; 6) the study of patients with a technically inadequate transthoracic approach.
Rev Esp Cardiol
PMID:[Ambulatory transesophageal echocardiography: 2 years of experience]. 175 25

This review highlights the contributions of recent pericyte research towards our understanding of normal and pathological functioning of microvessels. Pericytes are implicated in a variety of microvascular alterations, including wound healing, diabetes, inflammation, hypertension and neoplasia. They are capable of changing into other mesodermally derived cell types, including smooth muscle cells, osteoblasts and chondrocytes. The contractile properties of pericytes are being systematically examined in vitro; in addition to their tendency to contract spontaneously, pericytes can contract further in response to mediators of inflammation. In vivo studies indicate pericytes are concentrated near endothelial cell junctions along venules where they likely participate in inflammatory events. As agents are identified which modify pericyte responses to disease states, better therapeutic approaches will become possible.
Can J Cardiol 1991 Dec
PMID:Recent advances in pericyte biology--implications for health and disease. 176 82

A 24-year-old woman with pheochromocytoma associated with asymmetric septal hypertrophy, Wolff-Parkinson-White syndrome and pigmentation was operated on and the tumor was excised. The asymmetric hypertrophy and the pre-excitation disappeared after the operation, but the pigmentation increased. We discuss the relation between excessive catecholamines and these findings.
Int J Cardiol 1991 Sep
PMID:Pheochromocytoma with asymmetric septal hypertrophy and Wolff-Parkinson-White syndrome. 179 Oct 95

Twenty-five patients with main and peripheral pulmonary artery stenosis were studied to determine the most frequently observed diagnostic sign of this abnormality regardless of the underlying etiologies, such as intrinsic or extrinsic narrowing of the pulmonary artery due to tumor, fibromuscular dysplasia, thromboembolism, angitis including the aortitis syndrome (Takayasu arteritis) and a variety of other disease entities. Among a variety of signs and symptoms, we emphasized the importance of cardiac auscultation and phonocardiography, which were often the initial diagnostic clues. The diagnostic features included a systolic murmur of pulmonary arterial origin and the behavior of the splitting of the second heart sound. The systolic murmur was often trans-systolic or continuous. In cases with left-sided cardiac murmurs (Takayasu arteritis, etc), the pulmonary systolic murmurs were not identified by auscultation alone and required phonocardiographic confirmation. In many cases the second heart sound was split and this was sometimes the first clue to the diagnosis. The split intervals varied, but were more marked in cases with pulmonary hypertension, and were accompanied by the accentuated pulmonic component (IIP). Phonocardiographic analysis disclosed that wide splitting was caused by the delayed appearance of IIP as well as the concomitant early appearance of the aortic component (IIA). It was concluded that, although the final etiological diagnosis is not identified, auscultation and phonocardiography provide important clues for further diagnostic and etiological studies of pulmonary artery stenosis.
J Cardiol 1991
PMID:[Clinical features of main and peripheral pulmonary artery stenosis: significance of auscultation and phonocardiography]. 184 52

A patient with hepatoblastoma in whom a hepatobiliary study with Tc-99m PMT demonstrated homogeneous uptake in the tumor is presented. Sonography showed a large solid mass pedunculated from the right hepatic lobe with a "tumor-in-tumor" pattern. It was hypodense relative to normal hepatic parenchyma on CT scanning without contrast material and turned isodense with contrast material. This represented its hypervascularity, which was confirmed by selective celiac arteriography.
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PMID:A hepatobiliary study with Tc-99m N-pyridoxyl-5-methyltryptophan (PMT) in a patient with hepatoblastoma. 184 48


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